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Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus - and researchers from Karolinska Institutet in Sweden, together with international colleagues, have for the first time identified a key explanation for why these cells are unsuccessful in their task.

18 Jul 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

Thirteen scientists receive grant to identify new treatments, cure for psoriasis

Thirteen scientists received a total of $1.05 million in funding from the National Psoriasis Foundation for projects that aim to identify new treatments and a cure for psoriasis—an autoimmune disease that appears on the skin, affecting 7.5 million Americans—and psoriatic arthritis—an inflammatory arthritis that affects the joints and tendons, occurring in up to 30 percent of people with psoriasis.

16 Jul 2014

New genetic programs for taking blank-slate stem cells and turning them into human blood

The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.

14 Jul 2014

Research uncovers how complex protein pivotal in cancer development is activated

New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated.

10 Jul 2014

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical "switch" that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain.

4 Jul 2014

Transcription factor IRF4 plays key role in brown fat's thermogenic process

The body contains two types of fat cells, easily distinguished by color: White and brown. While white fat serves to store excess calories until they're needed by the body, brown adipocytes actually burn fat by turning it into heat.

4 Jul 2014

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Contrary to what was thought, sequences of DNA called enhancers - which control a gene's output - find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found.

4 Jul 2014

Thyroxine may overcome mutated thyroid hormone receptor effects

Patients with a mutation in the thyroid hormone receptor α gene that affects both the thyroid hormone receptor α1 and α2 protein variants have similar characteristics to patients with mutations affecting only the α1 variant, report researchers.

3 Jul 2014

Study explores new ways to improve medications to treat type 2 diabetes

A better understanding of how the transcription factor Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) works is critical to find new ways to improve medications to treat type 2 diabetes.

23 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Research provides unique insight into lncRNAs that regulate lung development

It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins.

19 Jun 2014

Researchers discover crucial process that regulates development of blood vessels

Biologists at The Scripps Research Institute (TSRI) have discovered a crucial process that regulates the development of blood vessels.

19 Jun 2014

Tufts researchers gain new insight into protein associated with bipolar disorder

Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in the June 3 issue of Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that regulate gene expression.

12 Jun 2014

Cancer drug offers protection against thrombosis

Case Western Reserve University researchers have discovered that an existing drug used to help cancer patients has the potential to protect thousands of others from the often-deadly impact of vascular clots.

12 Jun 2014

Molecular mechanisms regulating tumour initiation in skin SCC uncovered

Advanced online publication in Nature: Researchers at the Université libre de Bruxelles, ULB uncover the molecular mechanisms regulating tumour initiation and cancer stem cells functions in skin squamous cell carcinoma.

11 Jun 2014

Wistar findings suggest means of boosting initial immune response

Your first response to an infectious agent or antigen ordinarily takes about a week, and is relatively weak. However, if your immune system encounters that antigen a second time, the so-called memory response is rapid, powerful, and very effective.

10 Jun 2014

New findings on cellular signaling offer potential implications ranging from agriculture to cancer research

A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals about prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.

9 Jun 2014

Research finding paves way for targeted approaches to treating cancer patients

Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed - specifically how DNA gets transcribed into messenger RNA. Now his lab has found that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells if the repair goes wrong.

9 Jun 2014

TSRI develops accurate structural map of complex molecular machines in cells

A team led by researchers at The Scripps Research Institute (TSRI) has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most complex "molecular machines" in cells.

6 Jun 2014

Transcription News and Research

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

TAZ represents a novel therapeutic target in NSCLC

Thirteen scientists receive grant to identify new treatments, cure for psoriasis

New genetic programs for taking blank-slate stem cells and turning them into human blood

Research uncovers how complex protein pivotal in cancer development is activated

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

Transcription factor IRF4 plays key role in brown fat's thermogenic process

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Thyroxine may overcome mutated thyroid hormone receptor effects

Study explores new ways to improve medications to treat type 2 diabetes

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Research provides unique insight into lncRNAs that regulate lung development

Researchers discover crucial process that regulates development of blood vessels

Tufts researchers gain new insight into protein associated with bipolar disorder

Cancer drug offers protection against thrombosis

Molecular mechanisms regulating tumour initiation in skin SCC uncovered

Wistar findings suggest means of boosting initial immune response

New findings on cellular signaling offer potential implications ranging from agriculture to cancer research

Research finding paves way for targeted approaches to treating cancer patients

TSRI develops accurate structural map of complex molecular machines in cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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