Transcription Factors News and Research

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Tiny amounts of hydrogen sulfide could help people live healthier for longer

Future therapies to help people live healthy lives for longer could be developed from drugs that release tiny amounts of the gas hydrogen sulfide (H2S), new research has indicated.

31 Jul 2023

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells.

31 Jul 2023

Transcription factors may drive development of different colorectal cancer subtypes

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers.

27 Jul 2023

Lactate plays a critical role in helping neural stem cells develop into specialized neurons

Scientists at Tohoku University have discovered the critical role that lactate plays in helping neural stem cells develop into specialized neurons, a process dubbed neuronal differentiation.

24 Jul 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

Study identifies potential immune biomarker for pulmonary tuberculosis: a step towards early detection

Researchers have identified a potential immune biomarker associated with pulmonary TB in active patients compared to controls.

19 Jul 2023

Eternal youth? Chemical cocktails prove effective in cell age reversal

Researchers identified chemical drug combinations that could reverse cellular aging.

19 Jul 2023

Plant cell study reveals new role for enzyme in lipid metabolism

A new study by Rice University bioscientists explains how basic cellular structures common to most life forms collaborate to fuel growth in a model plant organism. The findings could shed light on corresponding mechanisms in human cells.

12 Jul 2023

Research reveals devastating impact of Western diet on human health

Research examines the impact of the Western diet on various aspects of health, including metabolism, inflammation, gut microbiota, cardiovascular health, mental health, and cancer. It provides insights into the effects of this dietary pattern on individuals and healthcare systems.

18 Jun 2023

Study illuminates how T cells fight and remember infections

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs.

13 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

New insights into how aggressive cancer cells proliferate and propagate the disease

Not all cancer metastases have the same destructive effect. Researchers demonstrate different mechanisms in experiments.

7 Jun 2023

Experts investigate the correlation between BORIS mutations and protein expression

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression."

6 Jun 2023

Groundbreaking study maps molecular architecture of the visual system's integral components

A groundbreaking study has taken a significant step towards understanding the complexities of the human eye.

4 Jun 2023

Targeting stem cells from the human stomach for treating diabetes

Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.

25 May 2023

Novel regulators of COPD determined by epigenetic profiling

Impaired function of lung fibroblast is considered causative for symptoms of the incurable lung disease COPD (Chronic Obstructive Pulmonary Disease).

25 May 2023

Newly developed method can help identify the special differences in genetic information

Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests.

22 May 2023

How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

Carotenoids' potential in reducing chronic disease risk

Researchers explore the association between the gastrointestinal delivery system and carotenoids.

15 May 2023

The Evolution of Molecular Biology

In this interview, Istvan Szatmari, the Head of The Genomic Core Facility at the Department of Biochemistry and Molecular Biology, talks to NewsMed about the evolution of Molecular Biology.

From MGI 4 May 2023