Transcription Factors News and Research

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New mutations near known genes could contribute to the increase in cleft lip and palate risk

Cleft lip and palate are among the most common congenital malformations, which are mainly due to genetic causes.

16 Dec 2022

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Back in 1971, the Bee Gees asked, "How can you mend a broken heart?". Now, researchers from Japan reveal that they may just have found a way to repair cardiac damage in patients suffering from chronic heart attack and heart failure.

16 Dec 2022

Using synthetic gene circuits to better control the timing of immunotherapy

In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales.

16 Dec 2022

Scientists uncover how FoxH1 factor binds to specific points in the genome

Transcription factors are proteins that interact with DNA to regulate the function of some genes. Generally, a single transcription factor binds to several regions in the genome as it orchestrates complex cellular responses, which require the activation or inhibition of several genes.

15 Dec 2022

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

Scientists use single-cell multi-omics data to map disease regulatory circuits

Researchers apply MAGICAL for the identification of modulated host response regulatory circuits in response to Staphylococcus aureus.

12 Dec 2022

Study looks at the possibility of promoting hair cell regeneration using cell reprograming

About 430 million people around the world experience disabling hearing loss. In the United States, approximately 37.5 million adults report some trouble hearing. Hearing loss can happen when any part of the ear or the nerves that carry information on sounds to the brain do not work in the usual way.

8 Dec 2022

New spatial cell atlas of the developing human lung identifies 144 cell states

The developing human lung has been mapped in unprecedented detail, identifying 144 cell states in the early stages of life, and uncovering new links between developmental cells and lung cancer.

8 Dec 2022

Early life experiences can affect gene activity more than half a lifetime later

Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.

1 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

Krill oil rewires global gene expression programs and promotes healthy aging

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 21, entitled, "Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging."

24 Nov 2022

Discovery could lead to new mantle cell lymphoma drugs

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

22 Nov 2022

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.

21 Nov 2022

New control system could be used to finely tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

1 Nov 2022

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

The University of Houston is leading a team of cancer researchers and experts in stem cell cloning to identify the origin of two very lethal cancers of the stomach and esophagus - esophageal adenocarcinoma (EAC) and intestinal gastric cancer (iGC).

27 Oct 2022

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Using a novel systems biology approach, scientists at University of California San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis (RA), a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.

24 Oct 2022

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Researchers examined the role of epigenetic modifications of the host cell gene expression in determining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and explored the use of vitamin D as a therapeutic agent against coronavirus disease 2019 (COVID-19).

19 Oct 2022

Bioinformatics analysis of monkeypox virus-host cell interactions

A recent study posted to the bioRxiv* preprint server reported the interaction between monkeypox and human cells. Molecular sequences were screened to identify differentially expressed genes (DEGs) and their associated signal pathway, expression regulation, and metabolic pathways.

18 Oct 2022

The role of oxidative stress in congenital syndromes

Researchers discuss the role of oxidative stress in genetic conditions.

10 Oct 2022

Transcription Factors News and Research

New mutations near known genes could contribute to the increase in cleft lip and palate risk

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Using synthetic gene circuits to better control the timing of immunotherapy

Scientists uncover how FoxH1 factor binds to specific points in the genome

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Scientists use single-cell multi-omics data to map disease regulatory circuits

Study looks at the possibility of promoting hair cell regeneration using cell reprograming

New spatial cell atlas of the developing human lung identifies 144 cell states

Early life experiences can affect gene activity more than half a lifetime later

Detection of filoviruses by the innate immune system

Flavonoids with potential to fight allergies and inflammation

Krill oil rewires global gene expression programs and promotes healthy aging

Discovery could lead to new mantle cell lymphoma drugs

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

New control system could be used to finely tune the production of useful proteins

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

Scientists use systems biology approach to identify molecular players in rheumatoid arthritis

Exploring epigenetic modifications and the use of vitamin D therapy in COVID-19

Bioinformatics analysis of monkeypox virus-host cell interactions

The role of oxidative stress in congenital syndromes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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