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New gene editing technique could hinder retinal degeneration in rats with inherited blindness

A new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinal degeneration in rats with a type of inherited blindness, according to a Cedars-Sinai study.

11 Jan 2016

Wyss Institute scientists develop better assay for testing hemostasis

Scientists at the Wyss Institute for Biologically Inspired Engineering at Harvard University have devised a better assay for testing blood's clotting tendency, also known as hemostasis, which could one day prove lifesaving in a variety of clinical situations in which a patient's health is jeopardized by abnormal blood coagulation and platelet function.

11 Jan 2016

New project aims to develop CAR-T cell immuno-oncology cellular therapy for solid tumours

The Cell Therapy Catapult, the UK organisation dedicated to the growth of the UK cell and gene therapy industry by bridging the gap between scientific research and commercialisation, the University of Birmingham and Cancer Research Technology, the commercialisation arm of Cancer Research UK, announces today the launch of a collaboration to develop a new immuno-oncology cellular therapy based on gene modifying T cells to target solid tumours.

8 Jan 2016

Diet or aerobic exercise improves ability to exercise for obese older patients with heart failure

Among obese older patients with a common type of heart failure, calorie restriction or aerobic exercise training improved their ability to exercise without experiencing shortness of breath, although neither intervention had a significant effect on a measure of quality of life, according to a study in the January 5 issue of JAMA.

6 Jan 2016

Researchers describe epigenetic mechanisms underlying the development of cerebellum

From before birth through childhood, connections form between neurons in the brain, ultimately making us who we are. So far, scientists have gained a relatively good understanding of how neural circuits become established, but they know less about the genetic control at play during this crucial developmental process.

23 Dec 2015

Human-gut-on-a-chip model offers hope for patients suffering from IBD

It's estimated that as many as 1,000,000 Americans suffer from inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, which cause mild to severe symptoms that at best can be managed and at worst can lead to life-threatening complications.

16 Dec 2015

ASU-led researchers add new worldwide resource to explore genes' deep and hidden messages

After a decade-long $3 billion international effort, scientists heralded the 2001 completion of the human genome as a moon landing achievement for biology and the key to finally solving intractable diseases like cancer.

12 Dec 2015

Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Some of the same gene mutations that cause heart defects in children also lead to neurodevelopmental delays, including learning disabilities. A large study of congenital heart disease (CHD) reveals overlapping genetic influences during early childhood development.

9 Dec 2015

Research reveals MECP2 Duplication Syndrome can be reversed

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett Syndrome while gene duplication causing over-expression lead to MECP2 Duplication Syndrome. Both disorders are severely debilitating childhood neurological diseases.

26 Nov 2015

New drug may show promise against resistant melanomas

A new drug discovered by scientists at Sanford Burnham Prebys Medical Discovery Institute may show promise for treating skin cancers that are resistant or unresponsive to today's leading therapies.

25 Nov 2015

RPCI-led researchers identify strategies to prevent acute kidney injury

Acute kidney injury (AKI), also known as acute renal failure, is one of the main contributors to death and disability worldwide, yet no preventive treatment for the condition has been established. In a new study published in the journal Cell Death and Differentiation, a team of researchers led by scientists from Roswell Park Cancer Institute reports that they have identified 10 genes whose inhibition appears to protect kidney cells.

25 Nov 2015

Vibration-based technology reduces apneic events, improves critical clinical parameters in premature infants

Scientists and clinicians at the University of Massachusetts Medical School, Wyss Institute for Biologically Inspired Engineering, and the Beth Israel Deaconess Medical Center have shown in a clinical trial that a new, vibration-based prevention technology tested in a neonatal intensive care unit (NICU) reduces apneic events and improves critical clinical parameters in prematurely born infants.

24 Nov 2015

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

Scientists from the Virginia Tech Carilion Research Institute and clinicians from Carilion Clinic have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.

20 Nov 2015

UF Health investigators make new discovery about Huntington's disease

University of Florida Health researchers have made a new discovery about Huntington's disease, showing that the gene that causes the fatal disorder makes an unexpected "cocktail" of mutant proteins that accumulate in the brain.

19 Nov 2015

Role of biomarkers in drug development and regulatory decision making

Biomarkers in Medicine, a leading MEDLINE-indexed journal, has published a special focus issue exploring the increasingly important role of biomarkers in both drug development and regulatory decision making.

19 Nov 2015

Houston Methodist invention named one of 100 most innovative technologies by R&D Magazine

R&D Magazine named the handheld single-cell pipette (hSCP), a Houston Methodist Research Institute invention, as one the 100 most innovative technologies and services of the past year.

19 Nov 2015

Georgia State University researchers develop a method to better trace and treat cancer

A method to better trace changes in cancers and treatment of the prostate and lung without the limitations associated with radiation has been developed by Georgia State University researchers.

18 Nov 2015

Seven researchers win 2015 Early Career Researcher UK Awards

The UK is a world-leader in breakthrough scientific discoveries, and seven of the early career researchers leading this field have been recognised for their contributions to areas including malaria elimination, securing water supplies for future generations and empowering patients in the management of their own health care.

6 Nov 2015

University of Leicester awarded BBSRC grant to explore three key areas that impact human health

The University of Leicester has been awarded over £1.5 million in order to advance knowledge and understanding in three key areas that impact on health.

5 Nov 2015

Experts to gather at DOHaD congress to address challenges that impact health of children, adolescents

Over 600 experts from around the world will meet to address the many challenges that currently impact the health of mothers, babies in the womb, infants, children and adolescents at the Society for the Developmental Origins of Health and Disease congress, which will be held in Africa for the first time.

5 Nov 2015

Translation News and Research

New gene editing technique could hinder retinal degeneration in rats with inherited blindness

Wyss Institute scientists develop better assay for testing hemostasis

New project aims to develop CAR-T cell immuno-oncology cellular therapy for solid tumours

Diet or aerobic exercise improves ability to exercise for obese older patients with heart failure

Researchers describe epigenetic mechanisms underlying the development of cerebellum

Human-gut-on-a-chip model offers hope for patients suffering from IBD

ASU-led researchers add new worldwide resource to explore genes' deep and hidden messages

Gene mutations that cause congenital heart disease also lead to neurodevelopmental delays

Research reveals MECP2 Duplication Syndrome can be reversed

New drug may show promise against resistant melanomas

RPCI-led researchers identify strategies to prevent acute kidney injury

Vibration-based technology reduces apneic events, improves critical clinical parameters in premature infants

Scientists identify way to sensitize drug-resistant glioblastoma cells to chemotherapy

UF Health investigators make new discovery about Huntington's disease

Role of biomarkers in drug development and regulatory decision making

Houston Methodist invention named one of 100 most innovative technologies by R&D Magazine

Georgia State University researchers develop a method to better trace and treat cancer

Seven researchers win 2015 Early Career Researcher UK Awards

University of Leicester awarded BBSRC grant to explore three key areas that impact human health

Experts to gather at DOHaD congress to address challenges that impact health of children, adolescents

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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