Triple Negative Breast Cancer News and Research

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Study shows how cancer cells force normal cells to act like viruses to enable tumor growth

In a study that could explain why some breast cancers are more aggressive than others, researchers say they now understand how cancer cells force normal cells to act like viruses – allowing tumors to grow, resist treatment, and spread.

19 Jul 2017

CWRU researcher receives major NIH grants to develop microscopic drug-delivery systems

Nicole F. Steinmetz, PhD, George J. Picha Professor in Biomaterials, member of the Case Comprehensive Cancer Center, and Director of the Center for Bio-Nanotechnology at Case Western Reserve School of Medicine, has received two major grants from the National Institutes of Health to develop microscopic drug-delivery systems for patients living with breast cancer, and patients at risk for serious blood clots.

29 Jun 2017

UAMS scientists show potential of world's smallest laser to kill single cancer cells

A University of Arkansas for Medical Sciences research team led by Vladimir Zharov, Ph.D., D.Sc., has demonstrated the ability to kill single cancer cells using the world's smallest laser.

9 Jun 2017

Immunotherapy combination offers new hope for women with early stage triple negative breast cancer

A Yale Cancer Center clinical trial combining the immune checkpoint inhibitor (durvalumab/MEDI4736) with chemotherapy as preoperative treatment for early stage triple negative breast cancer disclosed a 71% pathologic complete response to the combination treatment in the initial phase I trial.

2 Jun 2017

Researchers identify novel molecular mechanism involved in progression, metastasis of TNBC

University of Tsukuba-led researchers identified a novel molecular mechanism involved in progression and metastasis in the most aggressive form of breast cancer.

21 Apr 2017

Study: Cancer cells grow faster when transplanted into fatty, obese tissue

It's not just what's inside breast cancer cells that matters. It's also the environment surrounding cancer cells that drives the disease, according to researchers at the University of North Carolina Lineberger Comprehensive Cancer Center.

31 Mar 2017

New study discloses role of specific proteins in killing fast-duplicating cancer cells

Many cancer patients struggle with the adverse effects of chemotherapy, still the most prescribed cancer treatment. For patients with pancreatic cancer and other aggressive cancers, the forecast is more grim: there is no known effective therapy.

27 Mar 2017

Researchers develop nanoparticle to deliver potential new drug to breast cancer cells

The research, a collaborative project between Queen's University Belfast and Ulster University, began at the Queen's Centre for Cancer Research and Cell Biology in 2014, and was led by Professor Mohamed El-Tanani.

24 Mar 2017

Mayo study provides vital information on tumor sequencing in newly diagnosed breast cancer patients

Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown.

13 Mar 2017

TSRI researchers develop new drug candidates to target prostate and triple negative breast cancers

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

9 Mar 2017

Clinical study seeks to examine new combination therapy for treating AML patients

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

7 Mar 2017

Diabetes medication could be effective therapy for aggressive type of breast cancer

Researchers in China have discovered that a metabolic enzyme called AKR1B1 drives an aggressive type of breast cancer.

7 Mar 2017

Rheumatoid arthritis drug blocks metabolic pathway, reduces breast cancer tumors in mice

Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study to be published in Cancer Discovery.

3 Mar 2017

Metabolic vulnerability in triple-negative breast cancer cells may help quell chemotherapy resistance

A team of researchers led by Alex Toker of the Ludwig Center at Harvard has discovered a metabolic weakness in triple-negative breast cancer cells that may be exploited to quell their resistance to chemotherapy.

2 Mar 2017

Gene expression patterns could help predict treatment for breast cancer, research shows

A Michigan State University breast cancer researcher has shown that effective treatment options can be predicted based on the way certain breast cancer genes act or express themselves.

21 Feb 2017

High levels of biomarker linked to poor prognosis in African-Americans with triple-negative breast cancer

Having high levels of a certain biomarker is linked to poor prognosis in African-American patients with triple-negative breast cancer, while the same biomarker doesn't influence disease outcomes in white patients, according to a new study.

21 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017