Two photon Microscopy News and Research

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Two-photon microscopy (also known as two-photon fluorescence light microscopy) was invented in 1990 as a new method of imaging live cells and tissues in three-dimensions. Conventional fluorescence microscopy illuminates a specimen through the processes of excitation and emissions.

New method revolutionizes in vivo brain imaging in awake mice

The human brain has billions of neurons. Working together, they enable higher-order brain functions such as cognition and complex behaviors.

4 Mar 2024

Discovering distinct gut-brain pathways for sugars and fats

Researchers identify independent vagal sensing pathways for fat and sugar detection.

23 Jan 2024

Revolutionary transparent graphene microelectrodes enhance brain imaging and stimulation

The decoding of single-cell and average neural activities from surface potentials.

15 Jan 2024

Fine-tuning cell mechanics stimulates hair growth: Study

Just as people's joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study.

6 Jun 2023

Ultraflexible nanoelectrodes improve the efficacy of brain stimulation

Conventional implantable medical devices designed for brain stimulation are often too rigid and bulky for what is one of the body's softest and most delicate tissues.

30 May 2023

Powerful two-photon microscopy for imaging fast biological processes

Two-photon microscopy (TPM) has revolutionized the field of biology by enabling researchers to observe complex biological processes in living tissues at high resolution.

4 May 2023

Human cortical organoids implanted in mice establish functional connectivity and respond to sensory stimuli

A team of engineers and neuroscientists has demonstrated for the first time that human brain organoids implanted in mice have established functional connectivity to the animals' cortex and responded to external sensory stimuli.

29 Dec 2022

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Study shows how ketamine administration starkly changes neuronal activity patterns in the brain

Ketamine, an established anesthetic and increasingly popular antidepressant, dramatically reorganizes activity in the brain, as if a switch had been flipped on its active circuits, according to a new study by Penn Medicine researchers.

1 Dec 2022

New and unique technique to brain imaging has potential to save lives

Observing the brain without creating any breaks in the skull is an emerging technology for those studying various brain-related diseases.

5 Sep 2022

WVU professor receives $1.6 million to expand research on brain circuits

A fruit fly walks on a rolling ball. As it meanders, Kevin Daly, biology professor at West Virginia University, looks deep into its brain through a specialized microscope.

9 Aug 2022

New ultra-thin photoacoustic endomicroscopy probe can be easily integrated with medical devices

Researchers have created a photoacoustic imaging endoscope probe that can fit inside a medical needle with an inner diameter of just 0.6 millimeters.

28 Jul 2022

New evidence from a zebrafish model may help understand how epileptic seizures originate

New evidence from a zebrafish model of epilepsy may help resolve a debate into how seizures originate, according to Weill Cornell Medicine and NewYork-Presbyterian investigators.

20 Apr 2022

Brain refreshing takes place during the dream-active phase of sleep

Scientists have long wondered why almost all animals sleep, despite the disadvantages to survival of being unconscious.

25 Aug 2021

Previously unknown brain repair process could be harnessed to treat seizures and epilepsy

University of Virginia School of Medicine researchers have discovered a previously unknown repair process in the brain that they hope could be harnessed and enhanced to treat seizure-related brain injuries.

23 Jul 2021

Novel calibration process for super-resolution microscopy

Light--and all waves--can bend around the corners of obstacles found along its path. Because of this phenomenon, called diffraction, it is impossible to focus light onto a spot that is smaller than half its wavelength.

15 Jun 2021

New study sheds light on complex brain process that helps learn and form new memories

Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building connections among neurons, called synapses. How neurons do this--reaching out arm-like dendrites to communicate with other neurons--requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery.

19 Apr 2021

Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions

While the human brain has over 400 miles of total vasculature, little is known about the tiny capillaries that make up much of this intricate labyrinth of blood vessels critical for delivering oxygenated blood and nutrients to billions of brain cells.

19 Feb 2021

Mice study finds altered brain connectivity after prolonged anesthesia

Prolonged anesthesia, also known as medically induced coma, is a life-saving procedure carried out across the globe on millions of patients in intensive medical care units every year.

17 Feb 2021

Alterations in fetal microglia may lead to developmental and psychiatric disorders

Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders.

23 Dec 2020