Warfarin News and Research

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Warfarin is a drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).

Self-monitoring of Coumadin levels reduces risk of blood clots by 50%: Study

A new review of existing research finds that many patients who take an anti-clotting drug or "blood-thinner" can benefit from monitoring the levels of the drug themselves instead of going to clinics for blood tests.

16 Apr 2010

Consortium studies gene-drug relationship to determine optimal warfarin doses

If Julie Johnson had her way, doctors would check a patient's genes before writing a prescription. Everyone responds differently to medicines—one that works for you might not work for me, or it could even be harmful. These individual responses depend to an extent on our genetic make-up.

16 Apr 2010

Camp Okizu's brain tumor weekend program has new benefactor

Camp Okizu, a non-profit camp in northern California for kids with cancer and their families, has a new benefactor for its weekend program for families of children with brain tumors. In honor of Silicon Valley executive James W. Hebert, who died from a brain tumor at age 54 in 2006, his wife, Ronni Sarmanian, also a former tech executive, has committed to sponsor the event. This annual event, which will be called the James W. Hebert Family Camp, begins April 16 and coincides with Hebert's birthday, April 13.

13 Apr 2010

IDF awarded NIH grant for advancing knowledge in PIDD through continuance of USIDNET program

The Immune Deficiency Foundation (IDF) is pleased to announce that it has been awarded the grant "Resources to Assist Investigations in Primary Immunodeficiency Diseases" from the National Institutes of Health (NIH). This grant will allow IDF to continue to advance the detection, understanding, diagnosis and treatment of primary immunodeficiency diseases (PIDD) through their program, the United States Immunodeficiency Network (USIDNET).

13 Apr 2010

Pancreaze Delayed Release Capsules receive FDA approval

The U.S. Food and Drug Administration today approved Pancreaze Delayed Release Capsules, a pancreatic enzyme product. It is the third such product to receive FDA approval.

13 Apr 2010

Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

A five-year, $3.7 million clinical trial will investigate how to balance the benefits and risks of warfarin, a drug that helps prevent potentially deadly blood clots.

9 Apr 2010

Clinical testing service for safer dosing of warfarin

Machaon Diagnostics, California's only independent laboratory for testing bleeding and clotting disorders has launched a clinical testing service for patients that have been prescribed warfarin. Warfarin, also known as Coumadin, Jantoven or warfarin sodium, is a potent 'blood thinner' or anticoagulant.

8 Apr 2010

New report assesses optimal future for REMS

Two years after the Food and Drug Administration Amendments Act of 2007 gave FDA new powers to require Risk Evaluation and Mitigation Strategies for higher risk drugs and biologics, a new report concludes that an optimal future for REMS is possible if the agency adopts a systems approach when designing REMS programs and takes advantage of new technologies -- from electronic medical records to genetic testing -- that are changing the way medicine is practiced.

5 Apr 2010

Novel oral anticoagulants to drive venous thromboembolism drug market to $5 billion in 2018

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that the launches and widespread uptake of novel oral anticoagulants will drive the venous thromboembolism drug market to nearly double from $2.9 billion in 2008 to more than $5 billion in 2018 in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.

31 Mar 2010

Roche Diagnostics' CoaguChek XS Plus system granted CLIA-waived status

Roche Diagnostics announced today that the U.S. Food and Drug Administration (FDA) has granted CLIA-waived status to the CoaguChek® XS Plus system, a point-of-care anticoagulation monitor that offers connectivity and data management tools to help healthcare professionals manage PT/INR (blood clotting time) testing.

From Roche Sequencing and Life Science 31 Mar 2010

AGA Medical gets IDE approval to evaluate AMPLATZER Cardiac Plug

AGA Medical Holdings, Inc. today announced it has received conditional Investigational Device Exemption (IDE) approval from the U.S. Food and Drug Administration to evaluate the safety and efficacy of its AMPLATZER® Cardiac Plug, or ACP, to close the left atrial appendage.

25 Mar 2010

Study: Older adults with chronic illness often struggle to manage several prescribed drugs at a time

People with chronic illness often struggle to manage several prescribed drugs at a time. It's overwhelming when the vials, bottles and inhalers bulge from your medicine cabinet and you're confused about which drug is which, or when to take what.

20 Mar 2010

GenMark Diagnostics files registration statement with Securities and Exchange Commission

GenMark Diagnostics, Inc. announced today that it has filed a registration statement with the Securities and Exchange Commission for a proposed initial public offering of its common stock. GenMark is a Delaware corporation and, in connection with the offering, will become the parent holding company of Osmetech, plc.

19 Mar 2010

Atritech to initiate confirmatory study of WATCHMAN LAA Closure Device

Atritech, Inc., an emerging medical device company, announced today that it has obtained clarity from the U.S. Food and Drug Agency on the regulatory path towards full approval of its WATCHMAN® Left Atrial Appendage Closure Technology in the United States.

19 Mar 2010

TRITON-TIMI 38 study evaluates response rates in patients with common genetic variant in ABCB1 gene

A new analysis of the TRITON-TIMI 38 study evaluated response rates in patients with a common genetic variant in the ABCB1 gene. Patients enrolled in the TRITON-TIMI 38 study were treated with dual antiplatelet therapy with either Plavix® (clopidogrel) plus aspirin or Effient® (prasugrel) plus aspirin and managed with percutaneous coronary intervention (PCI) following an acute coronary syndrome (ACS) event.

17 Mar 2010

Genetic test helps reduce hospitalization rates for heart patients on warfarin

Hospitalization rates for heart patients taking warfarin, the world's most-prescribed blood thinner, dropped by approximately 30 percent when genetic information was available to doctors prescribing the drug, researchers from Medco Health Solutions, Inc.-- in association with the Medco Research Institute™ -- and Mayo Clinic announced today.

17 Mar 2010

Pathway Genomics' personal Genetic Health Report now available

Pathway Genomics Inc., a U.S. based genetic testing company, announced the immediate availability of its personal Genetic Health Report. This customized and innovative personal genetic health report contains information on more than 70 health conditions, including pharmacogenetics (prescription medication response), propensity for complex disease, and carrier status (pre-pregnancy health).

17 Mar 2010

Iverson Genetic Diagnostics to conduct WARFARIN clinical study

Iverson Genetic Diagnostics, Inc. today announced that they will conduct a WARFARIN clinical study to assess the efficacy of gene-based testing prior to initiating warfarin anticoagulation therapy to reduce the incidence of bleeding and thromboembolic events.

16 Mar 2010

RE-LY study: Dabigatran etexilate shows greater reductions in stroke compared to warfarin

Data presented today at the 59th Annual Scientific Session of the American College of Cardiology have shown greater reductions in stroke in patients with atrial fibrillation (AF) for dabigatran etexilate compared to the current standard of care, warfarin, irrespective of a patient’s risk profile for stroke.

16 Mar 2010

EXPLORE-Xa study: Betrixaban reduces CRNM bleeds compared to dose-adjusted warfarin

Portola Pharmaceuticals and Merck today announced the results of EXPLORE-Xa, a Phase 2 exploratory, dose finding study of betrixaban, an investigational oral direct Factor Xa inhibitor. Results showed that a once-daily dose of oral betrixaban, given to patients with non-valvular atrial fibrillation or atrial flutter and at least one risk factor for stroke, reduced the incidence of major and clinically relevant non-major (CRNM) bleeds compared to dose-adjusted warfarin.

16 Mar 2010

Warfarin News and Research

Further Reading

Self-monitoring of Coumadin levels reduces risk of blood clots by 50%: Study

Consortium studies gene-drug relationship to determine optimal warfarin doses

Camp Okizu's brain tumor weekend program has new benefactor

IDF awarded NIH grant for advancing knowledge in PIDD through continuance of USIDNET program

Pancreaze Delayed Release Capsules receive FDA approval

Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

Clinical testing service for safer dosing of warfarin

New report assesses optimal future for REMS

Novel oral anticoagulants to drive venous thromboembolism drug market to $5 billion in 2018

Roche Diagnostics' CoaguChek XS Plus system granted CLIA-waived status

AGA Medical gets IDE approval to evaluate AMPLATZER Cardiac Plug

Study: Older adults with chronic illness often struggle to manage several prescribed drugs at a time

GenMark Diagnostics files registration statement with Securities and Exchange Commission

Atritech to initiate confirmatory study of WATCHMAN LAA Closure Device

TRITON-TIMI 38 study evaluates response rates in patients with common genetic variant in ABCB1 gene

Genetic test helps reduce hospitalization rates for heart patients on warfarin

Pathway Genomics' personal Genetic Health Report now available

Iverson Genetic Diagnostics to conduct WARFARIN clinical study

RE-LY study: Dabigatran etexilate shows greater reductions in stroke compared to warfarin

EXPLORE-Xa study: Betrixaban reduces CRNM bleeds compared to dose-adjusted warfarin

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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