Whole Genome Sequencing News and Research

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Large-scale genetic study of E. coli illustrates complexity of drug resistant 'superbugs'

The first large-scale genetic study of Escherichia coli (E. coli) cultured from patients with bloodstream infections in England showed that drug resistant 'superbugs' are not always out-competing other strains.

18 Jul 2017

DNA links deadly germs, tainted heart surgery devices to German factory

Contamination at a German factory that makes crucial machines used during open-heart surgery is the likely source of a global outbreak of deadly infections tied to the devices, the largest analysis to date shows.

12 Jul 2017

Study shows potential of whole genome sequencing and AI to help clinicians scale precision oncology

In a study published today in the July 11, 2017 issue of Neurology Genetics, an official journal of the American Academy of Neurology, researchers at the New York Genome Center, The Rockefeller University and other NYGC member institutions, and IBM have illustrated the potential of IBM Watson for Genomics to analyze complex genomic data from state-of-the-art DNA sequencing of whole genomes.

11 Jul 2017

Safe under the ACA, patients with preexisting conditions now fear bias

Cheasanee Huette, a 20-year-old college student in Northern California, is worried. Two years ago, knowing she was protected by the Affordable Care Act's guarantees of coverage for preexisting conditions, she decided to find out if she carried the same genetic mutation that eventually killed her mother.

29 Jun 2017

Researchers trace origins of AML relapse to rare therapy-resistant stem cells

Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy begins.

29 Jun 2017

Complete DNA sequencing should not be feared according to researchers

It is now much easier than before to do a complete DNA sequencing of patients to look at all the three billion letters that make up a person’s genetic code or genome. DNA sequencing prices have fallen and it could soon be a part of routine medical tests experts suggest. However there is public fear associated with complete sequencing. Researchers looked at the fact if this fear was actually justified.

26 Jun 2017

Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

The blend of bacteria in the digestive tract of metastatic melanoma patients is associated with disease progression or delay in patients treated with immunotherapy, researchers at The University of Texas MD Anderson Cancer Center report at the 2017 annual meeting of the American Society of Clinical Oncology.

6 Jun 2017

ATCC and One Codex form partnership to address microbiome research needs

ATCC, a global leader in biological materials development, management and standards, and One Codex, a leading microbial genomics and metagenomics platform, today announced the formation of a partnership to address microbiome research needs.

2 Jun 2017

Gene editing technology can introduce hundreds of unintended mutations, study shows

As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.

29 May 2017

Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers

Whole-exome DNA sequencing -- a technology that saves time and money by sequencing only protein-coding regions and not the entire genome -- may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.

24 Apr 2017

Collaboration between Hamilton Robotics and Illumina creates noninvasive streamlined prenatal testing solution

Hamilton Robotics continues to strengthen their ongoing partnership with Illumina, Inc. through the collaborative development of the VeriSeq™ NIPT Solution for high-throughput noninvasive prenatal testing (NIPT).

From Hamilton Company 14 Apr 2017

Genetic screening and counseling likely to benefit childhood cancer survivors, study suggests

Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented today at the annual meeting of the American Association for Cancer Research.

4 Apr 2017

Rarely studied faulty USF3 gene may predispose individuals to thyroid cancer

Charis Eng, M.D., Ph.D., of Cleveland Clinic and her team have discovered that a faulty, rarely studied gene called USF3 may predispose individuals to thyroid cancer. They recently published this discovery in Human Molecular Genetics.

29 Mar 2017

Research shows how Ohr enzyme plays central role in bacterial anti-oxidant defense

A research project conducted at the University of São Paulo in Brazil in collaboration with other Brazilian research institutions and abroad has revealed new aspects of the action mechanism of organic hydroperoxide resistance (Ohr) enzyme, which enables several species of bacteria to neutralize oxidizing substances released by the defense system of the host organism, be it a plant or an animal.

21 Mar 2017

MLL, IBM and Illumina collaborate to build new cognitive technology prototype for improving leukemia treatment

Munich Leukemia Laboratory, a state-of-the-art leukemia and lymphoma diagnostic and research laboratory based in Munich, has teamed up with IBM and Illumina, Inc. to help build a new cognitive technology prototype that aims to help researchers improve leukemia treatment.

From Illumina, Inc. 9 Mar 2017

New report expresses ethical concerns about use of non-invasive prenatal testing

A new report on non-invasive prenatal testing by the UK's Nuffield Council on Bioethics expresses concerns about the way the test is being sold by private providers.

1 Mar 2017

UC San Diego researchers receive new grant to advance malaria research

An international research team, led by principal investigator Elizabeth A. Winzeler, PhD, professor in the pediatric division of host-microbe systems and therapeutics at University of California San Diego School of Medicine, and colleagues have received a three-year, $4.7 million supplemental grant from the Bill & Melinda Gates Foundation to advance their development of improved therapies for malaria eradication and elimination.

17 Feb 2017

Professor aims to develop shortcuts for targeted and effective cancer therapy

The aim is to identify precisely the one drug, or the correct combination of drugs, that are most effective against the specific tumor present in each patient. Professor hopes that new tools will come into use in the next five years.

13 Feb 2017

Scientists identify gene variants that predispose children to developing Kawasaki disease

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysms -- balloon-like bulges of heart vessels -- that may ultimately result in heart attacks, congestive heart failure or sudden death.

9 Feb 2017

Sapientia genome analysis software by Congenica could cut costs and save lives

Whole genome analysis (WGA) enables rapid diagnosis of rare disease, ensuring that an appropriate course of management and treatment can be administered, possibly within days for acute neonatal cases, cutting the cost of intensive care and potentially saving lives. Rapid diagnosis is one of the many benefits of using the Sapientia™ genome analysis and interpretation platform that Dr Nick Lench, Chief Operating Officer of Congenica, will be discussing at Precision Medicine World Conference (PMWC) 2017 on January 23rd at 3.15pm.

23 Jan 2017