immunity News and Research

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Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

Researchers conducted a comprehensive and systematic analysis of functional SARS-CoV-2 antibody profiles in a controlled randomized trial of severe COVID-19 hospitalized individuals treated with COVID-19 CCP.

25 Feb 2022

mRNA vaccines found to be highly effective against COVID-19 infections before the emergence of SARS-CoV-2 Delta variant

Researchers evaluated the efficacy of SARS-CoV-2 vaccines made by Pfizer, Jansen, and Moderna against symptomatic and asymptomatic COVID-19 cases.

25 Feb 2022

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Scientists evaluated the incidence and severity of breakthrough SARS-CoV-2 infections among individuals with immune-mediated inflammatory diseases undergoing B cell depleting therapy.

25 Feb 2022

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Researchers examined systemic B and T cell responses 16 weeks after BNT162b2 vaccination, and the potency of vaccine-induce neutralizing antibodies, in hemodialysis patients and healthcare workers with no comorbidities.

25 Feb 2022

T cell responses in inflammatory bowel disease patients on immune-modifying agents after mRNA COVID-19 vaccination

Researchers characterized humoral and SARS-CoV-2 S-specific T cell responses in IBD patients who received two-dose mRNA-based COVID-19 vaccination series.

25 Feb 2022

Application of various nanoparticle-capsulated siRNA as therapeutics for SARS-CoV-2 infection

In a review published in the International Journal of Molecular Sciences, researchers have been reviewing the use of siRNAs to target coronaviruses.

25 Feb 2022

Serological responses to heterologous COVID-19 mRNA vaccination in older individuals

Researchers assess the serological response to a real-world COVID-19 vaccination strategy in older individuals who resided in long-term care facilities.

24 Feb 2022

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Insilico Medicine, an end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that it has dosed multiple healthy volunteers in Phase I clinical trial evaluating ISM001-055, the first anti-fibrotic small molecule inhibitor generated by Insilico's AI-powered drug discovery platform for idiopathic pulmonary fibrosis (IPF).

24 Feb 2022

Scientists reveal the possibility to improve immunological memory in vaccines

A key transcription factor in T-cell immunology is crucial to the immune system's "memory" in recognizing threats it has already faced before – and it may be possible to improve this immunological memory in vaccines, according to a new paper by scientists at the Hackensack Meridian Center for Discovery and Innovation.

24 Feb 2022

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Researchers demonstrated that decorating the capsid surface of adenovirus vaccine vectors with a newly discovered protein superglue, DogTag/DogCatcher generates potent SARS-CoV-2-specific humoral and cellular immunity.

24 Feb 2022

Third dose of mRNA-based COVID-19 vaccine efficiently recalls Omicron-reactive B cell memory

A new study examined how the quantity and quality of antibody and memory B cell responses to SARS-CoV-2 change temporally and with the number of exposures to antigens.

24 Feb 2022

Antibody levels against SARS-CoV-2 spike protein up to 12 months after COVID-19 infection in non-vaccinated individuals

A recent study assessed the persistence of SARS-CoV-2 antibody five and 12 months post-infection in non-vaccinated patients.

24 Feb 2022

Omicron BA. 2 reinfections can occur shortly following BA.1 infection

Researchers investigated the probability of Omicron BA.2 reinfections following SARS-CoV-2 Omicron BA.1 initial infection by whole genomic sequencing in the period of dominance of these subvariants in Denmark.

24 Feb 2022

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Researchers used a systems immunology approach to analyze the immune states of healthy and non-obese subjects who recovered from mild COVID-19 and compared them with age- and sex-matched COVID-19-naive controls.

24 Feb 2022

Immunological landscape of England during Omicron-driven SARS-CoV-2 wave

In a new study, researchers determined the immunological landscape of England throughout the SARS-CoV-2 Omicron wave.

24 Feb 2022

Immune responses in patients with varying degrees of SARS-CoV-2 infection

In a recent research article published in the journal PLoS ONE, researchers looked at immunological responses in relation to established risk factors for serious illness. This prospective cohort study reports on long-lasting SARS-CoV-2 specific antibody and T-cellular immune responses six months after infection in rt-PCR confirmed cases of different illness severity (community and hospitalized patients).

24 Feb 2022

immunity News and Research

Protective immunity signatures provided by convalescent plasma for the development of COVID-19 antibody therapeutics

mRNA vaccines found to be highly effective against COVID-19 infections before the emergence of SARS-CoV-2 Delta variant

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

T cell responses in inflammatory bowel disease patients on immune-modifying agents after mRNA COVID-19 vaccination

Application of various nanoparticle-capsulated siRNA as therapeutics for SARS-CoV-2 infection

Serological responses to heterologous COVID-19 mRNA vaccination in older individuals

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Scientists reveal the possibility to improve immunological memory in vaccines

Study explores the boosting of SARS-CoV-2 adenovirus vaccine-induced immunity by capsid decoration

Third dose of mRNA-based COVID-19 vaccine efficiently recalls Omicron-reactive B cell memory

Antibody levels against SARS-CoV-2 spike protein up to 12 months after COVID-19 infection in non-vaccinated individuals

Omicron BA. 2 reinfections can occur shortly following BA.1 infection

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Immunological landscape of England during Omicron-driven SARS-CoV-2 wave

Immune responses in patients with varying degrees of SARS-CoV-2 infection

Study on Omicron related mortality in cancer patients during recent COVID wave

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

Understanding the immune responses after secondary vaccinations with Pfizer and Moderna vaccines

Study shows BCG vaccine provides no protection against SARS-CoV-2 in mice and hamsters

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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