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New real-time imaging technique holds great potential in shaping assisted reproduction procedures

Researchers at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed advanced microscopy technologies to monitor embryo development in real time, revealing how mammalian cells differentiate during the earliest stages of embryonic life.

23 May 2016

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

A team of researchers from Cornell University in Ithaca, New York demonstrated a drug delivery mechanism that utilizes two independent vehicles, allowing for delivery of chemically and physically dis-tinct agents.

23 May 2016

Natural proteins could be used to test new replacement hip, knee joints

A new study suggests that natural proteins can be used to effectively test new replacement hip and knee joints in the laboratory. The work could help with improving design in order to reduce wear and tear and increase the lifespan of such prosthetics.

20 May 2016

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

Using gene editing technology, researchers at the Lewis Katz School of Medicine at Temple University have, for the first time, successfully excised a segment of HIV-1 DNA - the virus responsible for AIDS - from the genomes of living animals.

20 May 2016

AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

Prostate cancer is the second leading cause of mortality among American men with the highest incidence rate of all cancers reported in the U.S. Male sex hormones testosterone (T) and 5α-dihydrotestosterone (5α-DHT) promote prostate cancer progression.

19 May 2016

ISSCR releases updated guidelines for stem cell research, development of new therapies

The International Society for Stem Cell Research, the world's largest professional organization of stem cell scientists, today released newly updated guidelines for stem cell research and the development of new clinical therapies.

13 May 2016

Gene therapy shows promise in treating glioblastoma

A team from the International School for Advanced Studies in Trieste has obtained very promising results by applying gene therapy to glioblastoma.

13 May 2016

Drug-repositioning strategy could help combat Chikungunya virus

Since 2013, the mosquito-borne Chikungunya virus has spread rapidly through South America and the Caribbean, and is now threatening Southern Europe and the southern US.

13 May 2016

Brazilian strain of Zika virus can cause severe birth defects

Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first "direct experimental proof" that the Brazilian strain of Zika virus can actually cause severe birth defects. The findings are published in the May 11 online issue of Nature.

12 May 2016

Optimization of endovenous laser ablation for varicose veins

A significant number of publications are devoted to results of investigations aimed at the development of methods of laser ablation for varicose veins. This is due to the fact that this method is an effective and minimally invasive technique for the treatment of varicose.

11 May 2016

Profiling gamma-retrovirus integration sites may help identify genes linked to specific cancer types

Identifying the sites where gamma-retroviruses commonly insert into the genome may help to identify genes associated with specific cancer types, according to a study published April 20, 2016 in the open-access journal PLOS ONE by Kathryn Gilroy at the University of Glasgow, UK, and colleagues.

10 May 2016

Study highlights role of specific chromosomal deletion in cancer development, progression

In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to reveal through the study of individual genes. Prof. Anna Sablina and her team at VIB/KU Leuven optimized a workflow for the generation of cell lines with targeted chromosomal deletions.

10 May 2016

lncRNA in placenta may help protect unborn baby from invading pathogens

The human placenta is an organ unlike any other. During the course of nine months it is formed by the embryo, sustains life and then is shed.

10 May 2016

CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

Stroke and Alzheimer's disease are major diseases imposing a huge burden on aging societies. It has long been recognized that stroke and Alzheimer's disease often co-occur, and it has been speculated that the two disorders have an overlapping pathogenesis.

10 May 2016

Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

We control their electrical activity. Cardiac cells are capable of producing and transmitting electric signals through changes in a cell membrane potential.

9 May 2016

New study analyzes financial savings and costs of medical complications associated with IVF

Heralded a miracle by many infertile couples, in vitro fertilization (IVF) can pack a painful financial punch for those without insurance coverage for the treatment. This prohibitive cost leads many would-be parents who pursue in vitro fertilization to transfer multiple embryos at once to increase their chances of getting a baby - and reduce the need to pay for subsequent attempts.

8 May 2016

Implication of microRNAs in cancer development greater than previously thought

Small, non-coding molecules called microRNAs are known to play an important role in cancer development. Researchers now have shown their significance is greater than previously thought, a finding that could lead to new therapeutic approaches for the most common and deadly form of ovarian cancer.

6 May 2016

Studies show mango consumption may contribute to protective health effects

Four new studies surrounding the effects of mango consumption suggest this superfruit has the potential to help combat adverse effects associated with high fat diets and obesity (animal study), as well inhibit growth of fat cells (anti-lipogenic properties in an in-vivo study), slow advancement of breast cancer tumors (animal study), as well as improve regularity and decrease inflammation associated with constipation (human subject study).

6 May 2016

New research shows molecular, cellular processes in human embroyo development

Despite significant biomedical advances in recent decades, the very earliest events of human development¬--those that occur during a critical window just after fertilization--have remained an unobservable mystery, until now.

5 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

in vitro News and Research

New real-time imaging technique holds great potential in shaping assisted reproduction procedures

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

Natural proteins could be used to test new replacement hip, knee joints

Gene editing technology helps excise segment of HIV-1 DNA from genomes of living animals

AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

ISSCR releases updated guidelines for stem cell research, development of new therapies

Gene therapy shows promise in treating glioblastoma

Drug-repositioning strategy could help combat Chikungunya virus

Brazilian strain of Zika virus can cause severe birth defects

Optimization of endovenous laser ablation for varicose veins

Profiling gamma-retrovirus integration sites may help identify genes linked to specific cancer types

Study highlights role of specific chromosomal deletion in cancer development, progression

lncRNA in placenta may help protect unborn baby from invading pathogens

CoSTREAM project aims to find common mechanisms, pathways in stroke and Alzheimer's disease

Controlling heart cells using a laser: an interview with Prof. Konstantin Agladze

New study analyzes financial savings and costs of medical complications associated with IVF

Implication of microRNAs in cancer development greater than previously thought

Studies show mango consumption may contribute to protective health effects

New research shows molecular, cellular processes in human embroyo development

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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