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Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.

10 Mar 2016

Secretory capacity of human gut does not decline with age, shows study

A breakthrough in basic research and the first comprehensive study on the secretory activity of the human intestine: over a period of eight years, Dr. Dagmar Krüger of the Department of Human Biology at TU Munich has examined more than 2200 specimens from around 450 patients with bowel disease.

10 Mar 2016

Tailored new compound can dramatically reduce brain damage resulting from stroke

After suffering a stroke, about three-fourths of patients exhibit some disability. The extent of a patient's symptoms depends on the degree and location of brain tissue damage following the stroke event. This week in ACS Central Science, researchers show that by using a tailored small molecule to turn off the production of a key neuromodulator in the brain, they can dramatically reduce brain damage in stroke models in rats.

10 Mar 2016

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells.

9 Mar 2016

Metabolic syndrome treatment benefits MS patients

Oral antidiabetic medications have beneficial anti-inflammatory effects in patients with multiple sclerosis and metabolic syndrome, providing support for a link between metabolism and autoimmunity, researchers report.

9 Mar 2016

New study assesses link between depression, anxiety and antidepressants and outcome of IVF

Depression and anxiety, and not necessarily the use of antidepressant medication, are associated with lower pregnancy and live birth rates following in vitro fertilisation, according to a large register study from Karolinska Institutet in Sweden. The findings are published in the journal Fertility & Sterility and can be of interest to clinicians treating infertility and for women with depression or anxiety planning to undergo fertility treatment.

8 Mar 2016

IVF could reduce unintended twin births

The twin birth rate in the U.S. has surged over the last 30 years, mostly because of reproductive technologies including in vitro fertilization. Though it's partly the cause, IVF could also be the most promising solution to reducing unintended twin births, argues Dr. Eli Adashi in a new editorial in the American Journal of Obstetrics & Gynecology.

7 Mar 2016

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

A study of obesity and related metabolic changes on bladder cancer incidence and deaths, and a plan to use stem cells to grow novel urinary tubes are among 10 research projects awarded funding by the Johns Hopkins Greenberg Bladder Cancer Institute.

7 Mar 2016

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

New BD Vacutainer Barricor Plasma Blood Collection tube earns CE mark approval

BD, a leading global medical technology company, announced today that it obtained the CE mark in Europe for a next-generation blood separation technology that is designed to enhance sample quality, improve laboratory efficiency and reduce laboratory turnaround time.

From BD (Becton, Dickinson and Company) 2 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Cardiac drug combats muscle cramps in ALS

A phase II study shows that the sodium channel blocker mexiletine has no specific safety concerns in patients with amyotrophic lateral sclerosis and, moreover, markedly reduces muscle cramps.

1 Mar 2016

Advances in the field of MPI: an interview with Professor Kannan Krishnan

In around 2004, there was a Phillips paper that discussed a new imaging technique called MPI. At that time, I had an eager, promising graduate student named Matt Ferguson who wanted a project, so I asked him to take a look.

From Bruker BioSpin - NMR, EPR and Imaging 1 Mar 2016

Novel therapeutic approach to target monomeric Tau protein

Dementia and other tauopathies, most notably Alzheimer's disease, embody a class of neurodegenerative diseases associated with the aggregation of the Tau protein in the human brain. These diseases represent one of the leading causes of death and disability in the elderly population in the western world, with no current effective therapy.

27 Feb 2016

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

For the first time, scientists at The Ohio State University have engineered new calcium receptors for the heart to tune the strength of the heartbeat in an animal model. The research is published online by the journal Nature Communications.

24 Feb 2016

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

Researchers at the Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona (IBB-UAB), in collaboration with the biopharmaceutical company SOM Biotech, located in the Barcelona Science Park (PCB), have published, in Nature Communications, the results of a drug repositioning study in which they describe a powerful drug, SOM0226 (tolcapone) that could significantly improve the pharmacological treatment of familial transthyretin amyloidosis (ATTR).

24 Feb 2016

New research reveals underlying biomechanics involved in meniscus fibrocartilage function

Knee injuries are among the top five reasons people visit an orthopedic surgeon for treatments, which include 719,000 total knee replacements performed annually in the United States. Now, new research reveals underlying biomechanics that may be involved in meniscus fibrocartilage function as well as dysfunction and could guide novel treatments for some of the most debilitating and costly orthopedic problems in the U.S., including meniscus tears and age-related joint degeneration.

22 Feb 2016

New project aims to develop low-cost device that can detect drug allergies within 30 minutes

The Universitat Politècnica de València (Polytechnic University of Valencia, UPV) is at the helm of a new Horizon2020 research project to develop a low-cost biophotonic device that can detect drug allergies within 30 minutes. Going by the acronym "Cobiophad", short for Compact Biophotonic Platform for Drug Allergy Diagnosis, it also receives funding from the European Technology Platform Photonics 21.

19 Feb 2016

Mtss1 'tumour suppressor' for CML

The metastasis suppressor 1 protein acts a tumour suppressor in chronic myeloid leukaemia stem cells, reveals research published in Leukemia.

17 Feb 2016

in vitro News and Research

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Secretory capacity of human gut does not decline with age, shows study

Tailored new compound can dramatically reduce brain damage resulting from stroke

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Metabolic syndrome treatment benefits MS patients

New study assesses link between depression, anxiety and antidepressants and outcome of IVF

IVF could reduce unintended twin births

Johns Hopkins Greenberg Bladder Cancer Institute awards grants for 10 bladder cancer research projects

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

New BD Vacutainer Barricor Plasma Blood Collection tube earns CE mark approval

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Cardiac drug combats muscle cramps in ALS

Advances in the field of MPI: an interview with Professor Kannan Krishnan

Novel therapeutic approach to target monomeric Tau protein

Ohio State researchers develop new approach to enhance heart function, cardiovascular performance

SOM0226 (tolcapone) drug could significantly improve pharmacological treatment of ATTR

New research reveals underlying biomechanics involved in meniscus fibrocartilage function

New project aims to develop low-cost device that can detect drug allergies within 30 minutes

Mtss1 'tumour suppressor' for CML

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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