Amyloid precursor protein (APP) is a type I integral membrane protein ubiquitously expressed in many tissues and concentrated in the synapses of neurons. It has three predominant splice variants: APP695, APP751, and APP770.

The majority of APP is cleaved at the plasma membrane by the α-secretase in the non-amyloidogenic pathway. The amyloidogenic pathway starts with β-secretase cleavage by BACE1 on the N-terminal part of the Aβ domain, releasing sAPPβ from a membrane-anchored fragment named βCTF or C99, which is subsequently cleaved by γ-secretase to release Aβ.

Brief information

  • Name: Beta amyloid A4 protein
  • Target Synonym: Beta-CTF, Amyloid Beta Precursor Protein, Cerebral Vascular Amyloid Peptide, Beta-Amyloid Precursor Protein, Amyloid-Beta A4 Protein, Beta-Amyloid Peptide, Alzheimer Disease, CTFgamma, ABETA, AAA, PN2, Amyloid beta-Peptides, Amyloid intracellular domain 57, APP, Amyloid intracellular domain 59, PN-II, Alpha-secretase C-terminal fragment, AICD-50, S-APP-alpha, A4, S-APP-beta, Alzheimer disease amyloid protein, Abeta40, Gamma-CTF(59), Abeta42, Gamma-CTF(57), Alpha-CTF, Amyloid intracellular domain 50, AID(59), Gamma-CTF(50), A
  • Number of Launched Drugs: 11
  • Number of Drugs in Clinical Trials: 39
  • Lastest Research Phase: Approved

Part of bioactivity data

Amyloid precursor protein (APP)

Image Credit: ACROBiosystems Inc.

  • FACS analysis of APP (GFP) on HEK293/Human APP (GFP) Stable Cell Line.
  • HEK293/Human APP (GFP) Stable Cell Line was red line, negative control HEK293 cells was grey line (QC tested).


Amyloid precursor protein (APP)

Image Credit: ACROBiosystems Inc.

The purity of Human APP Protein, His Tag (Cat. No. APP-H52H3), exceeds 85 %, and its molecular weight, as verified by SEC-MALS, is approximately 80-110 kDa. 


The purity of Human SAPPbeta, His Tag (Cat. No. APP-H52H5), exceeds 90 %, and its molecular weight, as verified by SEC-MALS, is approximately 95-115 kDa.

Amyloid precursor protein (APP)

Image Credit: ACROBiosystems Inc.

Synonym name

ABPP, APPI, Amyloid-beta A4 protein

Other Equipment by this Supplier

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.