Universal Shapefinder for Particle Characterization | QICPIC

Quality differences between batches with identical particle size distributions are frequently due to different particle shapes. Collective pharmaceutical properties such as flow behavior, tabletting capability, adhesion or abrasion behavior are directly related to the shape parameters of the individual particles. Dynamic image analysis with our modular QICPIC sensor combines characterization of particle size and particle shape of powders, fibers, granulates or suspensions ranging from below 1 µm to 34,000 µm. The modular particle size and shape analyzer developed the full power of dynamic image range analysis. High-speed image analysis using a pulsed light source with illumination times of less than 1 nanosecond cause the particles to be optically frozen while a high-resolution, high-speed camera images the razor-sharp particle projections with a resolution of up to 4 MP and frequency of up to 500 frames per second.

QICPIC’s powerful algorithms evaluate millions of particles in shortest time to guarantee superior statistically relevant results. Measures for length, width, equivalent circumference and diameter of a circle describe the size of a particle. Sphericity, aspect ratio and convexity provide information about the particle shape. Fibers can also be properly evaluated with length, diameter, straightness and elongation. All parameters may either be presented as distribution for the whole sample or individually for each single particle. A particle gallery with numerous selection and filter options supports the generation of specific and meaningful results. With the recorded particle video stored in the data-base the complete measurement can be viewed subsequently. QICPIC has an array of applications in the pharmaceutical industry from active ingredient synthesis, preformulation and manufacture of small pharmaceutical product quantities in early clinical phases through to manufacture of approved products on an industrial scale, particle characterization technology plays an important part both in product development as well as in quality and process control.

Optical Setup of QICPIC

Optical Setup of QICPIC

Measuring Ranges with Maximum Resolution

With a range of up to 7 precision lenses the overall particle measuring range from below 1 µm to 34 mm is covered. The wide dynamic measuring range of each optical module (1:2,000) the particle size and shape characterization of even wide distributed disperse products. Different levels of image capturing performance are realized with selected high speed and high-resolution CMOS cameras and matching interfaces. As the images of every single particle are assessed individually the quality of singling out particles is of prime importance.

QICPIC | Measuring ranges M3 to M9 from 0.55 µm to 34,000 µm with maximum resolution

QICPIC | Measuring ranges M3 to M9 from 0.55 µm to 34,000 µm with maximum resolution

Feature Highlights

  • Reliable and fast determination of particle size and particle shape as well as fiber characterization
  • Wide measuring range from < 1 µm to 34 mm
  • Fully compliant with ISO 13322-1/2 for image analyses standards
  • Flexible adaptation to a wide range of applications by modular system design with a great selection of dispersing and dosing units for dry and wet applications
  • Powerful evaluation modes | Meaningful results
  • Adaptable, high resolution size and shape distributions
  • High confidence level by fastest image acquisition allowing for a high number of particles

QICPIC-R Series

The high speed and high-resolution CMOS cameras using the latest data transfer and processing technologies. The particle analyzer QICPIC offers three levels of performance:

Sensor Measuring range/ Modules Max. frame rate/ FPS Data rate
QICPIC/R02 0.55 - 33,792 µm/ 4 from 7 225 @ 1.5 MP 5 GBit/s (1xUSB 3.0)
QICPIC/R06 0.55. 33,792 µm/ 4 from 7 500 @ 1.5 MP 10 GBit/s (2xCXP-5)
QICPIC/R16 0.70 - 24,192 µm/ 4 from 6 500 @ 4.0 MP 25 Gblt/s (4xCXP-6)

Modular System Design for Product-Specific Characterization

Applying dosing and dispersing units of modular design for dry and wet products ­the particle sizer QICPIC is flexible to adapt to powders, granules, fibers, suspensions and emulsions. This ensures a product-specific characterization of particle size and particle shape parameters matching the true nature of the application.

Dry Applications

  • RODOS | injection disperser for finest, even cohesive dry powders | 1.8 µm to 4,000 µm
  • GRADIS | gravity disperser for coarser, even fragile dry particulate systems | 5 µm to 34,000 µm
  • VIBRI | vibratory feeder for precise dosing and feeding of dry particulate systems (in combination with RODOS, GRADIS or OASIS)
  • ASPIROS | micro dosing system for feeding of small amounts of precious or toxic substances in encapsulated sample vials (in combination with RODOS or OASIS) | 5 µm to 500 µm
  • FIBROS | pre-disperser for gentle separation and feeding of dry, even curly fibres (in combination with GRADIS) | fibre thickness 5 µm to 5,000 µm, fibre length 500 µm to 30.000 µm

Wet Applications

  • LIXELL | wet disperser for emulsions and suspensions | 1 µm to 2,000 µm; with special flow-through cuvette also available for applications from 20 µm to 10,000 µm (e.g., pulp) | 5 µm to 4,000 µm
  • MIXCEL | modular wet disperser for emulsions and suspensions | 1 µm to 3,000 µm
  • FLOWCELL | open-loop cell for high volume with mid-size or coarse particles | 10 mm cell: 11 µm to 5,000 µm or 20 mm cell: 17 µm to 16,000 µm
  • LIQXI | dosing unit for suspensions and emulsions to 250 ml (in combination with LIXELL) | 0,1 µm to 500 µm

Specialities

  • OASIS | combined dry and wet disperser consisting of RODOS & SUCELL | 2 µm to 2,000 µm
  • MULTISAMPLER | sample handling system for automated feeding of dry and wet samples in 39 ml vials in batch operation (in combination with RODOS or QUIXEL) | 70 vials per rack