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eBook: Neurodegeneration Therapeutics Discovery

Chronic neuroinflammation is linked to the progression of neurodegenerative disorders. Microglia are the central nervous system’s resident macrophages, which mediate neuronal signaling and neuroinflammatory responses.

Cell Signaling Technology (CST) provides a diverse range of cell signaling markers related to chronic neurodegenerative conditions that can be reliably used to predict disease onset and progress. This eBook explores the solutions for advancing neurodegeneration therapeutics discovery.

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TREM2 Signaling

  • Syk/Phospho-Syk ELISA
  • DAP12 (TYROBP)
  • Pan Phospho-Tyrosine


  • ASC/TMS1
  • Gasdermin D
  • NLRP3
  • IL-1β/Cleaved IL-1β
  • Caspase-1/Cleaved Caspase-1

Cellular Readouts for Neuroinflammation

  • IL-1β/6/10
  • TNF-α
  • TGF-β
  • Stat3
  • Jak 

Cell Death

Cell death serves as a marker for neurodegenerative disease development. Neurons and glia can die and become pathogenic as a result of aberrant regulation of cell death and survival pathways, such as mitochondrial dysfunction, autophagy, and the stimulation of both apoptotic and non-apoptotic pathways.

Neurodegenerative disease progression can be accurately examined using validated antibodies, procedures, and sampler kits from Cell Signaling Technology (CST), which analyze the various kinds and activation states of cell death in human and rodent specimens.


  • RIP, Phospho-RIP (Ser166)/ (Ser14)
  • RIP3, Phospho-RIP3 (Ser227)/ (Thr231/Ser232)
  • MLKL, Phospho-MLKL (Ser358)/(Ser345)


  • Caspase-3, Cleaved Caspase-3 (Asp175)
  • PARP, Cleaved PARP (Asp214)
  • Caspase-8, Cleaved Caspase-8 (Asp374)
  • TUNEL Assay Kits


  • Gasdermin D, Cleaved Gasdermin D (Asp275)/(Asp276)
  • Cleaved IL-1β (Asp116)/ (Asp117)
  • Caspase-1, Cleaved Caspase-1 (Asp297)/(Asp296)

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