Posted in | Protein Analysis

Application of Microfluidic Diffusional Sizing (MDS) in deciphering mechanisms driving myosin filament dynamics

Join us for an insightful webinar on the structural dynamics of the cardiac muscle protein, myosin.

About this webinar:

Dr. Colleen Kelly, a renowned postdoctoral researcher from the Previs Lab at the University of Vermont, will discuss cellular and molecular methods used to study myosin.

Our expert speaker will describe how the combination of Microfluidic Diffusional Sizing (MDS) and fluorescence imaging techniques was utilized to provide evidence of a folded conformation of cytosolic cardiac myosin, further advancing our understanding of its dynamics in vivo. 

By attending this webinar, you will learn: 

  • An overview of macromolecular protein dynamics within the heart
  • Approaches used to examine protein dynamics from the cellular to molecular levels
  • The application of adeno-associated viral protein expression (AAV), two-photon imaging, fluorescence recovery after photobleaching (FRAP), and Microfluidic Diffusional Sizing (MDS)

About the speakers: 

Colleen completed her MS in Chemistry (2016) and Ph.D. in Biochemistry (2020) in the Gage Laboratory at the University of Massachusetts, Lowell. Her studies were focused on developing biophysical techniques to measure protein-protein interactions and to examine the folding of immunoglobulin-like domains in the muscle protein titin. During that time, she was also a high school chemistry and biotechnology teacher (10+ years).

Colleen is currently a second-year postdoc in the Previs Laboratory at the University of Vermont, where she is studying mechanisms of contractile protein replacement in the heart. Their results will enhance understanding of cardiac muscle development, heart health, and disease. 

Solving Channel Clogging Issues

Molly Coseno, Ph.D. is a Technical Marketing Specialist representing Fluidic Analytic in the United States.

Analysing more complex interactions

Who should attend this webinar? 

  • Experimentalists and trainees with an interest in fluorescence imaging, biophysical techniques, and/or protein chemistry.
  • Molecular physiologists with interest in contractile mechanics.

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