Angiogenesis News and Research

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Angiogenesis is blood vessel formation. Tumor angiogenesis is the growth of new blood vessels that tumors need to grow. This is caused by the release of chemicals by the tumor.

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

Amgen and UCB today announced results from the fourth year of a Phase 2 study showing the efficacy and safety of a second course of treatment with EVENITY™* (romosozumab), an investigational agent for postmenopausal women with osteoporosis.

3 Apr 2017

Study shows inhibition of transgelin prevents vasculogenic mimicry in breast cancer

An article published in Experimental Biology and Medicine identifies a new signaling pathway involved in breast cancer cell growth. The study, led by Dr. Chan-Wha Kim, from the Department of Biotechnology at Korea University in Seoul, reports that inhibition of the actin-binding protein transgelin prevents vasculogenic mimicry (VM), a process that provides tumor cells with the nutrients required for growth.

29 Mar 2017

New RNAi treatment safely blocks ocular inflammation in mice

Scientists have developed a new RNA interference therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy.

14 Feb 2017

Scientists discover cause of tumour resistance to angiogenesis inhibitors

A new study conducted by MedUni Vienna in collaboration with scientists from Hungary and Sweden has now shown for the first time that the success of specialised drugs to inhibit blood supply to tumours - so-called angiogenesis inhibitors - is compromised by the fact that these drugs do not effectively penetrate the tumour tissue and so do not reach the smallest blood vessels in the tumour.

25 Jan 2017

Natural compound could reduce risk of developing triple-negative breast cancer metastasis

More than 100 women die from breast cancer every day in the United States. Triple-negative breast cancers, which comprise 15 to 20 percent of all breast tumors, are a particularly deadly type of breast disease that often metastasize to distant sites.

24 Jan 2017

New drugs that target neighbour proteins may help halt cancer progression

Cancer is caused by an accumulation of genetic changes in a cell, that overcome the normal checks and balances leading to uncontrolled growth. A complex, interacting network of proteins controls all of a cell's processes, from metabolism to growth and division.

24 Jan 2017

Researchers develop innovative technique to examine and quantify blood vessels in the brain

A study published today in the Journal of Anatomy has made an important breakthrough in the examination of blood vessels in the brain giving scientists a clearer understanding of how dementia, brain cancer and stroke can affect veins and capillaries in this organ.

5 Jan 2017

Rice bioengineers reveal how heart valves use different strategies to handle oxygen starvation

As the valves in a heart stretch with each beat, their cells take in life-giving oxygen. But if the supply is cut off, aortic and mitral valves use different strategies to compensate, according to Rice University scientists.

21 Dec 2016

New erectile dysfunction treatment uses high-frequency acoustical waves

Statistically speaking, 50% of all men, have experienced erectile dysfunction (ED) at some time or another, and the chance of developing ED increases as you age. The medical management of ED has evolved greatly over the past several decades.

16 Dec 2016

Combination of demineralized bone and gene therapy shows promise for treating pseudarthrosis

A team headed by Professor Albert Rizvanov, director of the Gene and Cell Technologies Open Lab, created a gene therapy drug that encodes growth factors for the stimulation of blood vessel and bone formation.

2 Dec 2016

New review highlights challenges of studying resistance to antiangiogenic treatment in preclinical models

New blood vessel growth, or angiogenesis, is critical for cancer to grow and spread throughout the body.

21 Nov 2016

Sleep apnea can make lung cancer more dangerous by increasing tumor growth

A team of researchers from the University of Chicago and the University of Barcelona has found that intermittent hypoxia, or an irregular lack of air experienced by people with sleep apnea, can increase tumor growth by promoting the release of circulating exosomes.

17 Nov 2016

Experimental drug outperforms standard first-line therapy for advanced kidney cancer patients

An experimental kidney cancer drug outperformed the standard first-line therapy for patients with metastatic disease who are considered at risk for poorer than average outcomes, according to results of a randomized phase II clinical trial by researchers at Dana-Farber Cancer Institute.

15 Nov 2016

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

A new study led by scientists at The Scripps Research Institute suggests there may be a way to limit tumor growth by targeting immune system cells called macrophages.

11 Nov 2016

Research shows potential way to counteract glioblastoma growth by blocking PPARα receptor

One of the most remarkable features of glioblastoma is the metabolic reprogramming of cancerous cells, resulting in uncontrolled cell proliferation, hypoxic conditions and angiogenesis.

27 Oct 2016

Researchers find new path to stop metastatic growth of cancer

Investigators from the Research Institute of the McGill University Health Centre, and the Institute of Cancer Research, London, have discovered that some cancer cells can draw blood from existing mature blood vessels allowing them to continue to spread.

18 Oct 2016

UC3M scientists use mathematical description to explain how tumors induce growth of blood vessels

Universidad Carlos III de Madrid has carried out a study that mathematically explains how tumors induce the growth of blood vessels. The study maintains that the tips of the blood vessels expand like a soliton, a solitary wave similar to a tsunami.

17 Oct 2016

Research reveals role of endoglin in shaping blood and cardiac cell fate during early development

New research from the University of Minnesota reveals endoglin as a critical factor in determining the fate of early undifferentiated cells during development.

7 Oct 2016

Gender matching key for corneal transplants? An interview with Professor Kaye

The cornea is a transparent tissue lining the front of the eye, that is invisible tissue to the naked eye. It is a delicate tissue and disease or injury may lead to a loss of transparency or a change in the shape of the cornea, resulting in severe visual impairment.

19 Sep 2016

Could a light-listening photonics device detect skin disease? An interview with Prof. Vasilis Ntziachristos

Detection of malignant skin alterations is currently aided by optical microscopes such as dermoscopes or optical microscopes. While the latter offers high resolution, it comes with a major disadvantage, just like any other purely microscopic method: it only provides a partial view of the skin due to the low penetration depth.

29 Aug 2016