ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Stopping RAS inhibitors linked to risk of adverse outcomes in patients with chronic kidney disease

Small studies have suggested that a group of medications called RAS inhibitors may be harmful in persons with advanced chronic kidney disease, and physicians therefore often stop the treatment in such patients.

29 Dec 2020

Could the keto diet help prevent or mitigate severe COVID-19?

A new study published in the journal of Translational Medicine reports that the ketogenic diet (KD) may be useful in this area, with its track history of effectual reduction of fat mass, anti-inflammatory and immunomodulatory effects, and consequent improvement of cardiovascular health.

30 Nov 2020

Genetic mutation may accelerate heart function decline in DMD patients

A mutation in the gene that causes cystic fibrosis may accelerate heart function decline in those with Duchenne muscular dystrophy (DMD), a new study by UT Southwestern researchers suggests.

4 Nov 2020

Study finds sex differences among young individuals who suffer a heart attack

Women aged 50 or younger who suffer a heart attack are more likely than men to die over the following 11 years, according to a new study published today (Wednesday) in the European Heart Journal.

13 Oct 2020

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

A recent paper published in the preprint server medRxiv in September 2020 discusses the “clinically relevant variation in the expression of COVID-19-related genes”, which is associated with the host and environmental factors, as well as host genetic factors.

6 Oct 2020

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Early in the onset of the COVID-19 pandemic, a small study in China produced results that influenced subsequent research on the virus.

18 Sep 2020

Azithromycin use for treating COVID-19 may increase risk of cardiac events

Debates over whether hydroxychloroquine should be taken to help lessen the duration and impact of COVID-19 have revolved around the drug's reputation for causing cardiac events such as abnormal heart rhythms or beats and cardiac arrest.

16 Sep 2020

Computational models screen for coronaviruses likely to infect humans

The researchers from Rochester Institute of Technology and the Hauptmann-Woodward Medical Research Institute produced models of the receptor-binding domain (RBD) found on outbreak strains of betacoronaviruses and its interaction with the host cell receptor angiotensin-converting enzyme 2 (ACE2).

14 Sep 2020

Mount Sinai hospitals win top quality achievement awards for stroke and cardiac care

Seven Mount Sinai Health System hospitals have received top quality achievement awards from the American Heart Association for ensuring that patients with stroke, heart failure, and severe heart attacks receive the most appropriate and safest treatment for the best possible outcomes.

1 Sep 2020

Common heart drugs are safe for patients hospitalized with COVID-19

Heart patients hospitalized with COVID-19 can safely continue taking angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), according to the BRACE CORONA trial presented in a Hot Line session today at ESC Congress 2020.

1 Sep 2020

$Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction$

Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction

Sacubitril/valsartan reduces NT-proBNP, a biomarker predictive of long-term clinical outcomes in heart failure, but does not improve functional capacity compared to individualized background therapy in patients with heart failure with preserved ejection fraction

1 Sep 2020

SGLT2 inhibitors can slow CKD progression

850 million people worldwide are affected by chronic kidney disease (CKD) - a worrying figure, and one that continues to rise.

31 Aug 2020

Antihypertensive drugs are not linked to cancer, shows study

There is no evidence that blood pressure lowering drugs increase the risk of cancer, according to the most extensive study conducted on the topic. The late breaking research is presented today at ESC Congress 2020.

31 Aug 2020

Premenopausal women have favorable long-term outcomes after heart attack, shows study

Premenopausal women have good long-term outcomes after a heart attack, according to late breaking research presented today at ESC Congress 2020.

31 Aug 2020

Common high blood pressure medications do not increase risk of depression

None of the 41 most common high blood pressure medications increased the risk of depression, while nine medications appeared to lower it, according to a study from Denmark, published today in Hypertension, an American Heart Association journal.

24 Aug 2020

New model predicts which COVID-19 patients are at higher risk for hospitalization

Cleveland Clinic researchers have developed and validated a risk prediction model (called a nomogram) that can help physicians predict which patients who have recently tested positive for SARS-CoV-2, the virus that causes COVID-19, are at greatest risk for hospitalization.

12 Aug 2020

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

7 Aug 2020

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

In a new bioRxiv study, authors identified a isoform of ACE2 (designated as deltaACE2 or dACE2) receptor, shown to be induced in various human cell types.

23 Jul 2020

Common hypertension drugs do not increase risk of severe, fatal COVID-19 infection

A new Northwestern Medicine study in mice found a widely used class of drugs to treat patients with hypertension, cardiovascular disease and diabetic kidney disease - many of whom are elderly -- does not increase the risk of developing a severe and potentially fatal COVID-19 infection, as previously feared.

22 Jul 2020

Novel blood test for heart failure could lead to new diagnostics for COVID-19 patients

A new blood test that reliably predicts outcomes for heart failure patients could lead to new diagnostics and treatments for COVID-19 patients as well, according to newly published research from cardiologists at the University of Alberta.

20 Jul 2020

ACE Inhibitors News and Research

Further Reading

Stopping RAS inhibitors linked to risk of adverse outcomes in patients with chronic kidney disease

Could the keto diet help prevent or mitigate severe COVID-19?

Genetic mutation may accelerate heart function decline in DMD patients

Study finds sex differences among young individuals who suffer a heart attack

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Azithromycin use for treating COVID-19 may increase risk of cardiac events

Computational models screen for coronaviruses likely to infect humans

Mount Sinai hospitals win top quality achievement awards for stroke and cardiac care

Common heart drugs are safe for patients hospitalized with COVID-19

Sacubitril/valsartan therapy may reduce hospitalization in heart patients with preserved ejection fraction

SGLT2 inhibitors can slow CKD progression

Antihypertensive drugs are not linked to cancer, shows study

Premenopausal women have favorable long-term outcomes after heart attack, shows study

Common high blood pressure medications do not increase risk of depression

New model predicts which COVID-19 patients are at higher risk for hospitalization

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

Study shows interferons do not induce the expression of SARS-CoV-2 cell entry receptor

Common hypertension drugs do not increase risk of severe, fatal COVID-19 infection

Novel blood test for heart failure could lead to new diagnostics for COVID-19 patients

Hasret Altan-Martin

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