ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Study shows link between use of NHB therapy and increased survival for patients with LVADs

A new Yale study shows that some patients being treated for severe heart failure with a battery-operated pump saw significant improvement after additionally using neurohormonal blockade (NHB) drug therapy.

19 Nov 2019

Study compares safety and effectiveness of first-line antihypertensive drug classes

For those with extremely high blood pressure, or hypertension, there are many initial medication options -- so many that it can be hard to know which one to use.

25 Oct 2019

First-line antihypertensives may not be most effective, study shows

Thiazide diuretics demonstrate better effectiveness and cause fewer side effects than ACE inhibitors as first-line antihypertensive drugs, according to a report published Oct. 24 in The Lancet.

25 Oct 2019

Most popular first-line treatment for hypertension may be less effective than alternative drugs

A new multinational study shows that the most popular first-line treatment for hypertension is less effective and has more side effects than an alternative that's prescribed much less often.

25 Oct 2019

Rapamycin is more effective at slowing down aging, says researcher

The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today.

17 Oct 2019

Heart failure medication often prescribed in lower dosages than recommended

Important medication for the treatment of heart failure are often prescribed in lower dosages than recommended by international guidelines.

1 Oct 2019

Beta-blockers reduce mortality in patients with heart failure and moderate kidney dysfunction

Beta-blockers remain effective for preventing death in heart failure with reduced ejection fraction (HFrEF) and sinus rhythm, even in patients with moderate or moderately-severe kidney dysfunction, according to late breaking research presented in a Hot Line Session today at ESC Congress 2019 together with the World Congress of Cardiology.

3 Sep 2019

ESC guidelines highlight detrimental impact of pollution, noise on patients with chronic coronary syndromes

The detrimental impact of pollution and noise on patients with chronic coronary syndromes is highlighted for the first time in European Society of Cardiology (ESC) Guidelines published online today in European Heart Journal, and on the ESC website.

31 Aug 2019

FDA approves novel device to treat symptoms associated with advanced heart failure

The U.S. Food and Drug Administration today approved the Barostim Neo System for the improvement of symptoms in patients with advanced heart failure who are not suited for treatment with other heart failure devices, such as cardiac resynchronization therapy.

18 Aug 2019

Women more likely to be under-treated for heart disease

The large-scale analysis carried out by La Trobe University researchers and published in Heart found that many Australians living with CHD are under-prescribed recommended medications, are not monitored for major risk factors and have treatments that do not achieve recommended goals.

23 Jul 2019

Blood pressure medication associated with increased risk of diverticulosis

A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with an increased risk of a type of bowel condition called diverticulosis.

3 Jul 2019

Chemotherapy can wreak havoc on the heart

Cheryl Krafft was diagnosed with an aggressive form of non-Hodgkin's lymphoma and was put on a very high-powered chemotherapy regimen to rid her body of the cancer. What she was not counting on was the chemotherapy causing another equally deadly problem.

21 Jun 2019

Research paves way for new treatment to protect people from cardiovascular disease

New University of Alberta research is paving the way for the first medical treatment to help protect people from cardiovascular disease by boosting the body's natural defenses.

17 Jun 2019

Antihypertensive drug use linked with reduction in dementia risk

Various clinical trials indicate what effects can be expected from standardized intervention programs on the basis of existing evidence.

3 Jun 2019

Study shows improvements in cardiovascular risk for women developing Type 2 diabetes despite prescription bias

A Diabetes UK-funded study suggests that Type 2 diabetes leads to a smaller increase in the risk of cardiovascular disease for women today than it has done in the past.

15 Apr 2019

New device approved by FDA for treating patients with moderate-to-severe heart failure

The U.S. Food and Drug Administration today approved the Optimizer Smart system for treating patients with chronic, moderate-to-severe heart failure who are not suited for treatment with other heart failure devices such as cardiac resynchronization therapy to restore a normal timing pattern of the heartbeat.

22 Mar 2019

Research: Pure omega-3 prescription drug significantly reduces the occurrence of ischemic events

Taking a high dose of icosapent ethyl--a pure and stable prescription form of the omega-3 fatty acid known as EPA--significantly reduces the occurrence of first, subsequent and total ischemic events, including heart attacks, strokes and related deaths, among people at high cardiovascular risk despite already being on statin therapy, according to research presented at the American College of Cardiology's 68th Annual Scientific Session.

19 Mar 2019

Two-drug combinations containing calcium channel blocker significantly lowers BP

In the largest randomized controlled trial of treatment for high blood pressure ever conducted in sub-Saharan Africa, two frontline two-drug combinations that included the long-acting calcium channel blocker, amlodipine, were able to drive down blood pressure levels more than a third two-drug combination that did not include amlodipine, according to research presented at the American College of Cardiology's 68th Annual Scientific Session.

19 Mar 2019

Novel treatment targeting fibroblasts may prevent heart failure after heart attack

Heart attack survivors are at greater risk of developing heart failure, a chronic condition in which more than half of those diagnosed will die within five years.

5 Mar 2019

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor.

7 Feb 2019

ACE Inhibitors News and Research

Further Reading

Study shows link between use of NHB therapy and increased survival for patients with LVADs

Study compares safety and effectiveness of first-line antihypertensive drug classes

First-line antihypertensives may not be most effective, study shows

Most popular first-line treatment for hypertension may be less effective than alternative drugs

Rapamycin is more effective at slowing down aging, says researcher

Heart failure medication often prescribed in lower dosages than recommended

Beta-blockers reduce mortality in patients with heart failure and moderate kidney dysfunction

ESC guidelines highlight detrimental impact of pollution, noise on patients with chronic coronary syndromes

FDA approves novel device to treat symptoms associated with advanced heart failure

Women more likely to be under-treated for heart disease

Blood pressure medication associated with increased risk of diverticulosis

Chemotherapy can wreak havoc on the heart

Research paves way for new treatment to protect people from cardiovascular disease

Antihypertensive drug use linked with reduction in dementia risk

Study shows improvements in cardiovascular risk for women developing Type 2 diabetes despite prescription bias

New device approved by FDA for treating patients with moderate-to-severe heart failure

Research: Pure omega-3 prescription drug significantly reduces the occurrence of ischemic events

Two-drug combinations containing calcium channel blocker significantly lowers BP

Novel treatment targeting fibroblasts may prevent heart failure after heart attack

Study finds underutilization of aspirin to prevent colorectal cancer in high risk patients

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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