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Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

In a recent study posted to the medRxiv* pre-print server, Australian researchers comprehensively investigated the impact of 39 receptor-binding-domain (RBD) mutations in six severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and variants of interest (VOIs).

12 Jul 2022

Persistence of SARS-CoV-2 in tissues leads to long COVID

PASC is likely the result of long-term persistence of SARS-CoV-2 in various tissues

11 Jul 2022

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

Researchers investigated sex-based differences among COVID-19 patients in the United States.

11 Jul 2022

SARS-CoV-2 spike protein downregulates ACE2 expression

In a new study, researchers observed the downregulation of ACE2 by SARS-CoV-2.

11 Jul 2022

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

A new study has focused on identifying plant secondary metabolites (PSM) having a higher affinity for S-RBD of SARS-CoV-2.

11 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

A recent study published in the Science journal depicted that mosaic receptor-binding domain (RBD) nanoparticles immunize from diverse sarbecovirus challenges, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), among animal models.

8 Jul 2022

Discovery of multiple new SARS-CoV-2 MPro inhibitors

In a recent study posted to the bioRxiv* preprint server, researchers performed an extensive library docking for new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) covalent and non-covalent inhibitors.

8 Jul 2022

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

In a recent study under review at the Nature Portfolio journal and currently available on the Research Square* preprint server, researchers identified immune priming conditions that generated broadly neutralizing antibody (nAb) responses and assessed immunity post-third dose of coronavirus disease 2019 (COVID-19) vaccines such as BNT126b2 or Coronavac vaccines after two homologous doses of BNT126b2 or Coronavac vaccines.

7 Jul 2022

SARS-CoV-2 RBD vulnerability discovered - target for antibodies against variants

A new study successfully identified a potent neutralization epitope in SARS-related coronaviruses.

6 Jul 2022

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

Researchers assessed the different mutations of concern in the SARS-CoV-2 receptor-binding domain.

6 Jul 2022

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Researchers identified SARS-CoV-2 spike surfaces involved in binding to host cell membranes.

6 Jul 2022

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

In a recent study posted to the medRxiv* pre-print server, researchers developed a mechanistic mathematical model to predict the course of vaccine-induced immunity in healthy and immunosuppressed patients for the long term, exceeding the time frames for which clinical data is currently available.

5 Jul 2022

Immune response triggered by COVID-19 damages the brain's blood vessels to cause neurological complications

A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain's blood vessels and may lead to short- and long-term neurological symptoms.

5 Jul 2022

Deep RNA sequencing with molecular dynamic simulations can detect neutralizing antibodies elicited by COVID-19 patients

In a new study, researchers reported on the non-ACE2 blocking neutralizing antibodies elicited in response to severe coronavirus disease 2019 using deep ribonucleic acid sequencing with >100 million reads per sample and molecular dynamic simulations.

5 Jul 2022

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Vitamin D supplementation reduces inflammation, after H1N1 and SARS-CoV-2 infections in mice.

5 Jul 2022

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

In a recent study published in the journal Science Immunology, researchers in the United States described a rare anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) three antibody cocktail IMM-BCP-01.

4 Jul 2022

SARS-CoV-2 infection of lung endothelial cells and pulmonary capillary microthrombosis

Researchers evaluated the presence of RNA of SARS-CoV-2 in lung tissue of deceased patients.

4 Jul 2022

Brain immune response to SARS-CoV-2 infection

In a recently published article in the journal Current Opinion in Neurobiology, scientists at Washington University School of Medicine, St. Louis have described how immunological alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may impact brain activities and induce acute and post-acute neurological symptoms in coronavirus disease 2019 (COVID-19) patients.

3 Jul 2022

Scientists develop antibody test to keep track of immunity to SARS-CoV-2 variants

The experts agree -; the pandemic is not over. Infections are ticking up again, fueled by the new variants our immune systems are ill prepared for.

1 Jul 2022

ACE2 News and Research

Scientists investigate impact of SARS-CoV-2 RBD mutations across variants

Persistence of SARS-CoV-2 in tissues leads to long COVID

Study reveals sex-based differences in the clinical outcomes of COVID-19 in the US

SARS-CoV-2 spike protein downregulates ACE2 expression

Study assesses the potential of plant secondary metabolites as potential anti-COVID-19 agents

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

Nanoparticle vaccine could protect against animal viruses including future SARS-CoV-2 variants

Discovery of multiple new SARS-CoV-2 MPro inhibitors

Broadness of neutralizing antibodies to sarbecoviruses depends on priming conditions

SARS-CoV-2 RBD vulnerability discovered - target for antibodies against variants

Scientists explore mutations in the SARS-CoV-2 receptor-binding domain

The host cell membrane binding surfaces of SARS-CoV-2 spike variants

Healthy, cancer, and immunosuppressed patients all benefit from COVID boosters

Immune response triggered by COVID-19 damages the brain's blood vessels to cause neurological complications

Deep RNA sequencing with molecular dynamic simulations can detect neutralizing antibodies elicited by COVID-19 patients

Vitamin D protects against H1N1 and SARS-CoV-2 infection in mice

Patient-derived antibody cocktail active across SARS-CoV-2 variants of concern

SARS-CoV-2 infection of lung endothelial cells and pulmonary capillary microthrombosis

Brain immune response to SARS-CoV-2 infection

Scientists develop antibody test to keep track of immunity to SARS-CoV-2 variants

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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