Adenovirus News and Research

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Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress.

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Promising early stage results from a phase 1/2 clinical trial of the UK's vaccine candidate against SARS-CoV-2 (the virus that causes COVID-19) are published today in The Lancet.

20 Jul 2020

Oxford University and AstraZeneca to publish eagerly-anticipated COVID-19 trial results today

The coronavirus pandemic is still rapidly spreading across the globe, infecting more than 14.44 million people. With more than 188 countries and territories affected, scientists are racing to develop a vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19).

19 Jul 2020

Cancer drug could help inhibit adenovirus infection

An adenovirus infection can be potentially life-threatening, especially for children after a stem cell transplant.

14 Jul 2020

As winter comes other viruses will compete with SARS-CoV-2 for susceptible hosts

A new study published on the preprint server medRxiv in July 2020 traces how COVID-19 became the predominant cause of respiratory infection in the period from early January until the present.

10 Jul 2020

Cerebrospinal fluid autoantibodies target the brain in some COVID-19 patients

A study conducted by German researchers has shown that the neurological symptoms observed in some patients with coronavirus disease 2019 (COVID-19) may be caused by autoantibodies targeting the brain.

7 Jul 2020

Human trials of potential COVID-19 vaccine commence in South Australia

A potential COVID-19 vaccine developed at Flinders University has commenced human trials in South Australia.

6 Jul 2020

Oxford COVID-19 vaccine trials move to stage 3 human trials

The technical name of the vaccine is ChAdOx1 nCoV-19 (AZD1222), as it is made from a virus called ChAdOx1, which is a weakened and non-replicating version of a common cold virus (adenovirus). The vaccine has been engineered to express the SARS-CoV-2 spike protein.

5 Jul 2020

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

A new study published on the preprint server bioRxiv in June 2020 shows that a candidate spike protein vaccine can induce neutralizing antibodies, antiviral T cell responses, and protection against infection.

2 Jul 2020

First clinical trial in South Africa for Covid-19 vaccine begins

The first clinical trial in South Africa and on the continent for a Covid-19 vaccine was announced today, 23 June 2020, at a virtual press conference hosted by the University of the Witwatersrand, Johannesburg (Wits).

23 Jun 2020

Dire warning on contamination of water and COVID-19 spread

A recent report by scientists in the United Kingdom and Poland and published on the preprint server medRxiv in June 2020 describes the presence of stable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in water for up to 25 days, with the risk of infection by the contaminated water varying by the country’s environment.

22 Jun 2020

Scientists show how harmless adenovirus disrupts the heart's electrical signaling

Adenovirus, which typically can cause a common cold, has a far more dangerous impact if it reaches the heart.

22 Jun 2020

SARS-CoV-2 found in river water, flags risk for humans, wildlife and livestock

Now, a new study by scientists in Ecuador and published on the preprint server medRxiv in June 2020 shows that the virus is present in river water too, which could imply a significant transmission risk in developing countries with inadequate sanitation facilities.

17 Jun 2020

Cobra and AstraZeneca sign supply agreement for manufacture of COVID-19 vaccine candidate

Cobra Biologics, part of the Cognate BioServices family, an international CDMO for biologics and pharmaceuticals, today announced it has signed a supply agreement with AstraZeneca UK Ltd. to provide GMP manufacture of the adenovirus vector-based COVID-19 vaccine candidate AZD1222, previously known as ChAdOx1 n-CoV-19.

From AstraZeneca 17 Jun 2020

Researchers develop a simple tool for making mouse models of COVID-19

Until there are effective treatments or vaccines, the COVID-19 pandemic will remain a significant threat to public health and economies around the world. A major hurdle to developing and testing new anti-viral therapies and vaccines for COVID-19 is the lack of good, widely available animal models of the disease.

16 Jun 2020

COVID-19 mouse model could accelerate the search for treatments, vaccines

The global effort to quickly develop drugs and vaccines for COVID-19 has been hampered by limited numbers of laboratory mice that are susceptible to infection with SARS-CoV-2, the virus that causes COVID-19.

10 Jun 2020

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

By combining T and B lymphocyte analysis with manufacturability heuristic, researchers from the US and Germany proposed a set of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine peptides to use in subsequent animal studies and clinical trials. Their paper is currently available on the bioRxiv preprint server.

7 Jun 2020

Adenovirus News and Research

Further Reading

Oxford University and AstraZeneca vaccine against SARS-CoV-2 safe and induces immune response

Oxford University and AstraZeneca to publish eagerly-anticipated COVID-19 trial results today

Cancer drug could help inhibit adenovirus infection

As winter comes other viruses will compete with SARS-CoV-2 for susceptible hosts

Cerebrospinal fluid autoantibodies target the brain in some COVID-19 patients

Human trials of potential COVID-19 vaccine commence in South Australia

Oxford COVID-19 vaccine trials move to stage 3 human trials

Novavax SARS-CoV-2 vaccine candidate shows promise in animal models

First clinical trial in South Africa for Covid-19 vaccine begins

Dire warning on contamination of water and COVID-19 spread

Scientists show how harmless adenovirus disrupts the heart's electrical signaling

SARS-CoV-2 found in river water, flags risk for humans, wildlife and livestock

Cobra and AstraZeneca sign supply agreement for manufacture of COVID-19 vaccine candidate

Researchers develop a simple tool for making mouse models of COVID-19

COVID-19 mouse model could accelerate the search for treatments, vaccines

New strategy may facilitate development of multi-epitope peptide vaccine against SARS-CoV-2

Scientists create adenovirus that kills cancer cells

CanSino's potential coronavirus vaccine triggers immune response in clinical trial

First COVID-19 vaccine found to be safe, able to generate rapid immune response in phase 1 clinical trial

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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