Adenovirus News and Research

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Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress.

New findings on STEP HIV vaccine trial

The study is the result of the collaboration between scientists at the Institut de Genetique Moleculaire de Montpellier, Universite Montpellier I & II, Montpellier, France, the Centre Hospitalier Universitaire Vaudois (CHUV) and at the Swiss Vaccine Research Institute, University of Lausanne, Lausanne, Switzerland.

4 Nov 2008

Study shows how HIV-1 vaccine trial could have enhanced HIV infection

In September 2007, a phase II HIV-1 vaccine trial was abruptly halted when researchers found that the vaccine may have promoted, rather than prevented, HIV infection.

4 Nov 2008

Transformation of ordinary cells into insulin-makers improves symptoms of diabetes

Scientists in the U.S. have successfully transformed ordinary cells into insulin-producing cells in a living mouse and thereby improved the symptoms of diabetes.

28 Aug 2008

Trial of new AIDS vaccine bites the dust

Plans to conduct a large-scale human trial of an experimental HIV/AIDS vaccine in the United States have bitten the dust.

21 Jul 2008

NIAID will not conduct the PAVE 100 HIV vaccine study

After soliciting and considering broad input from the scientific and HIV advocacy communities, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), has determined that it will not conduct the HIV vaccine study known as PAVE 100.

17 Jul 2008

Discovery of gene mechanism could lead to new therapeutic strategies to fight metastatic disease

Virginia Commonwealth University and VCU Massey Cancer Center researchers have uncovered how a gene, melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), induces a bystander effect that kills cancer cells not directly receiving mda-7/IL-24 without harming healthy ones, a discovery that could lead to new therapeutic strategies to fight metastatic disease.

1 Jul 2008

Jefferson scientists discover way to immunize mice against metastatic disease

Taking advantage of the fact that the intestines have a separate immune system from the rest of the body, scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have found a way to immunize mice against the development of metastatic disease.

24 Jun 2008

Investigational smallpox drug may treat adenovirus infections in humans

Scientists at Saint Louis University have made two key discoveries that could lead to the first-ever human testing of a drug to target the adenovirus, which causes a number of severe upper-respiratory infections and is one of many viruses that causes the common cold.

19 May 2008

Mechanism discovered that can send cells on the road to cancer

Using a common virus as a tool for investigating abnormal cell proliferation, a team led by scientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in clarifying an intricate series of biochemical steps that shed light on a way that cancer can begin.

22 Apr 2008

Purdue's new vaccine under development may provide protection against highly pathogenic bird flu

A new vaccine under development may provide protection against highly pathogenic bird flu and its evolving forms, according to researchers at Purdue University and the Centers for Disease Control and Prevention who discovered the new preventative drug and have tested it in mice.

17 Apr 2008

Clinical trial to test a novel HIV/AIDS vaccine

This new vaccine aims to overcome the problem of preexisting immunity to common vaccine vectors, which is thought to be a major problem in the developing world.

4 Apr 2008

Novel approach may lead to safer delivery of genetic therapies

A novel strategy for circumventing safety problems that have plagued gene therapy has been offered by a complex multicenter group of researchers, including Professor Claudio Napoli, a Full Professor at the II University of Naples and Adjunct Professor at the Sbarro Research Institute for Cancer Research and Molecular Medicine and the Center of Biotechnology at the College of Science and Technology of Temple University.

24 Mar 2008

Discovery of new mechanism involved in inflammatory diseases

Investigators at Hospital for Special Surgery have identified a new mechanism involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis.

17 Mar 2008

Modified virus vaccine shows promise in mouse model of breast cancer

Researchers have shown that vaccinating mice with a modified form of a virus containing proteins from breast cancer cells can kill large breast cancer tumors and tumors that have spread to the lungs.

17 Mar 2008

Study confirms link between colds and ear infections

A new five-year study at the University of Texas Medical Branch at Galveston confirms the suspected close link between the two most common diseases of young children: colds and ear infections.

14 Mar 2008

New vaccine for malaria under trial

Trials are underway, funded by the Wellcome Trust, for a new vaccine to combat the most deadly form of malaria.

5 Feb 2008

New research advancements in the treatment of premature ovarian failure

Scientific Director of the Meharry Center for Women's Health Research and a team of researchers from the University of Texas Medical Branch and the University of Saskatchewan have recently discovered that the gene mutation believed to be a possible cause of premature ovarian failure may be corrected when an adenovirus compensating for the mutated gene is introduced. Findings were reported in the recent issue of Molecular Human Reproduction.

15 Jan 2008

FDA clears test for 12 specific respiratory viruses

The U.S. Food and Drug Administration has cleared for marketing a test that simultaneously detects and identifies 12 specific respiratory viruses.

4 Jan 2008

Some AIDS vaccines may damage the immune system

Researchers in the United States say some of the viruses being used in experimental AIDS vaccines may cause damage to the immune system.

19 Nov 2007

Some viral-vector vaccines may cause more harm than good

Leading efforts to create an HIV vaccine have hinged on the use of viruses as carriers for selected elements of the HIV virus. Recently, however, evidence has emerged that some of these so-called viral vector systems may undermine the immune system and should not be used for vaccine development.

16 Nov 2007