Adiponectin News and Research

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Study shows the benefits of once-weekly prednisone in obese mice

Obese mice that were fed a high-fat diet and that received prednisone one time per week had improved exercise endurance, got stronger, increased their lean body mass and lost weight, reports a new Northwestern Medicine study published in The Journal of Experimental Medicine.

1 Apr 2022

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss.

28 Jan 2022

New therapeutic approach offers hope to treat obesity and related metabolic disorders

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a new therapeutic approach to obesity and related metabolic disorders that in laboratory experiments demonstrated a significant reduction in body fat, body weight, and improvement in the blood markers that accompany these disorders.

25 Jan 2022

Fat-secreted molecule may cancel out the effects of common breast cancer treatment

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.

9 Nov 2021

Engineered 3D scaffolds of human brown adipose tissue as a new therapeutic strategy for obesity and diabetes

A group of researchers from various institutes in the USA addressed the limitations of BAT therapy by transplanting a low dose of brown adipocytes (BAs) without Matrigel to determine if this could alleviate high-fat diet-induced OB, metabolic symptoms, and T2DM in mice.

18 Oct 2021

COVID-19 may trigger hyperglycemia by disrupting key metabolic signals to cause severe disease

COVID-19 may bring high risks of severe disease and death in many patients by disrupting key metabolic signals and thereby triggering hyperglycemia, according to a new study from researchers at Weill Cornell Medicine and NewYork-Presbyterian.

2 Oct 2021

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

A new study discusses the role of obesity in COVID-19 and its role in antibody-mediated immune responses to the COVID-19 vaccine.

7 Sep 2021

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity.

12 Aug 2021

University of Liverpool signs option agreement with BARD1 for type 3C diabetes test

The University of Liverpool has signed a two year option agreement with the Australian diagnostics company, BARD1 Life Sciences Ltd (ASX: BD1), for a type 3c diabetes (T3cDM) blood test. The test uses patented technology developed by researchers in the University of Liverpool's Institute of Systems, Molecular and Integrative Biology.

7 Jul 2021

Researchers report promising biotherapeutics for obesity and related medical complications

The research teams at the University of Hong Kong led by Professor Xuechen LI from the Research Division for Chemistry and Department of Chemistry, and Professor Yu WANG from the Department of Pharmacology and Pharmacy, reported a synthetic biotherapeutics with promising anti-tumor, insulin sensitising and hepatoprotective activities in the Journal of the American Chemical Society.

18 May 2021

Inflammasomes could play an important role in the development of obesity-related colon cancer

New research presented at this year's European Congress on Obesity (held online, 10-13 May) finds evidence that structures called inflammasomes (a part of the innate immune system that helps to regulate inflammation) could play an important role in the development of obesity-associated colon cancer.

10 May 2021

Regular consumption of sardines helps prevent the onset of type 2 diabetes

The health benefits of sardines and oily fish are widely known: their high levels of unsaturated fats help to regulate cholesterol levels and prevent the onset of cardiovascular diseases. However, the benefits don't end there.

6 May 2021

Changing diet and exercise can make chemotherapy more effective in youth with leukemia

Overweight children and adolescents receiving chemotherapy for treatment of leukemia are less successful battling the disease compared to their lean peers.

1 Apr 2021

Modest dietary changes and exercise can improve survival outcomes for young people with leukemia

In some cancers, including leukemia in children and adolescents, obesity can negatively affect survival outcomes. Obese young people with leukemia are 50% more likely to relapse after treatment than their lean counterparts.

1 Apr 2021

Stem cell based cell culture model to recapitulate important aspects of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. Around 30% of the population have lipid droplets stored in their liver which diminish its function in the long term.

25 Jan 2021

Researchers identify new biomarkers associated with incident heart failure

Researchers at the University of Eastern Finland and Kuopio University Hospital have discovered several new biomarkers that are associated with incident heart failure.

16 Dec 2020

Fat cell hormone enhances therapeutic potential of MSC therapy

Mesenchymal stem cells (MSCs) have the potential to differentiate into a range of different cell types, including bone, fat, and muscle cells.

12 Jul 2020

Risk prediction model identifies people at higher risk of pancreatic cancer

Bottom Line: A risk prediction model that combined genetic and clinical factors with circulating biomarkers identified people at significantly higher than normal risk of pancreatic cancer.

22 Apr 2020

DsbA-L gene may play a role in protecting respiratory function of the elderly

The lungs are constantly exposed to the external environment and maintain homeostasis by adapting to stress and tissue damage.

6 Apr 2020

Melinjo seed extract may improve obesity and diabetes

In Southeast Asia, the fruit, flowers, and leaves of Indonesia's "Melinjo" tree are traditional foods.

23 Mar 2020