Age Related Macular Degeneration News and Research

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Molecular Partners completes MP0112 phase I/IIa trials in wet AMD, DME

Molecular Partners AG, a leader in the development of next generation therapeutics, announced today that it has completed two phase I/IIa clinical trials with MP0112, its lead molecule targeting VEGF-A.

28 Apr 2011

Maternal consumption of omega-3 fatty acids during pregnancy reduces risk of childhood obesity

New research shows a possible connection between the risk of childhood obesity and maternal consumption of omega-3 fatty acids during pregnancy. Intake of the omega-3s found in seafood is also linked to reduced risk of recurrent breast cancer, stroke in women and early age-related macular degeneration (AMD).

27 Apr 2011

Promedior to present PRM-151 study data in age-related macular degeneration at ARVO meeting

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic, inflammatory and neovascular diseases, today announced that data from preclinical studies of PRM-151 will be presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology, being held May 1-5, 2011 in Ft. Lauderdale, FL.

22 Apr 2011

ACT seeks European MHRA clearance to initiate hESC derived RPE cell Phase 1/2 study in SMD

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today that it has filed a clinical trial application (CTA) with the European Medicines and Healthcare products Regulatory Agency (MHRA) seeking clearance to initiate its Phase 1/2 clinical trial using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) to treat patients with Stargardt's Macular Dystrophy (SMD).

21 Apr 2011

FDA accepts Regeneron's VEGF Trap-Eye BLA for review

Regeneron Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration has accepted for review the Company's Biologics License Application for VEGF Trap-Eye for the treatment of the neovascular form of age-related macular degeneration.

18 Apr 2011

Older women with high vitamin D status less likely to have early AMD

Women under the age of 75 with high vitamin D status were less likely to have early age-related macular degeneration, the leading cause of irreversible vision loss in adults, a University at Buffalo study has shown. The disease affects approximately 9 percent of Americans aged 40 and older.

12 Apr 2011

Long-term delivery of CNTF slows loss of visual acuity caused by geographic atrophy

A phase 2 clinical trial for the treatment of a severe form of age-related macular degeneration called geographic atrophy (GA) has become the first study to show the benefit of a therapy to slow the progression of vision loss for this disease. The results highlight the benefit of the use of a neurotrophic factor to treat GA and provide hope to nearly one million Americans suffering from GA.

8 Apr 2011

Bayer, Regeneron initiate two VEGF Trap-Eye Phase 3 trials in Diabetic Macular Edema

Regeneron Pharmaceuticals, Inc. and Bayer HealthCare announced that they have initiated the first of two Phase 3 clinical trials evaluating the efficacy and safety of VEGF Trap-Eye, an investigational new agent for the treatment of certain eye diseases, in the treatment of Diabetic Macular Edema.

8 Apr 2011

Neurotech’s NT-501 intraocular implant slows progression of vision loss in GA subjects

Neurotech Pharmaceuticals, Inc., today announced that it was reported in the Proceedings of the National Academy of Sciences that its product candidate NT-501 slowed progression of vision loss in patients with geographic atrophy (GA) associated with dry age-related macular degeneration (AMD) in a Phase 2 study.

6 Apr 2011

Scientists develop new software to test alterations in night vision

Researchers from the Department of Optics of the University of Granada, belonging to the Laboratorio de Ciencias de la Visi-n y Aplicaciones, have developed a programme for testing alterations in night vision, and the tool required to implement it, which has been named "halometer".

25 Mar 2011

ACT to be awarded broad patent protection in China for hESC-derived RPE cells

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today that China's State Intellectual Property Office (SIPO) has allowed the Company's patent application to provide broad intellectual property protection in China for the manufacturing and pharmaceutical preparations of retinal pigment epithelial (RPE) cells from human embryonic stem cells (hESCs).

24 Mar 2011

Researchers create hiPS-RPE cells to treat age-related macular degeneration

The notion of transplanting adult stem cells to treat or even cure age-related macular degeneration has taken a significant step toward becoming a reality. In a study published today in Stem Cells, Georgetown University Medical Center researchers have demonstrated, for the first time, the ability to create retinal cells derived from human-induced pluripotent stem cells that mimic the eye cells that die and cause loss of sight.

24 Mar 2011

SMR, RTU enter license agreement for RESCULA eye drops

Sucampo Pharmaceuticals, Inc. today announced that its wholly owned subsidiary, Sucampo Manufacturing & Research AG, and R-Tech Ueno, Ltd., a pharmaceutical company founded in Japan in 1989, have entered into a license agreement for RESCULA eye drops, expanding Sucampo's rights beyond its previously agreed territory of the United States and Canada to all countries in Europe and the rest of the world except Japan, Korea, Taiwan and the People's Republic of China.

23 Mar 2011

Advanced Cell Technology reduces 2010 debt to less than $1 million

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today 2010 year-end results for the period ended December 31, 2010. The Company utilized $8.8 million in cash for operations during the year, compared to $5.1 million in the year-earlier period.

21 Mar 2011

Eating fish protects from blindness: Study

According to latest study fish that is rich in omega 3 fatty acids significantly lowers the risk of developing age-related macular degeneration that leads to blindness. The study was published in the Archives of Ophthalmology.

17 Mar 2011

Eating fatty fish reduces blindness risk from AMD: Study

New research has shown that consuming omega-3 fatty acids that are most commonly found in oily fish such as tinned salmon and tuna, could prevent the onset of age-related macular degeneration (AMD), a condition that leads to the gradual loss of vision. The required amount may be as low as one to two portions of fish a week that can reduce the risk of sight loss by up to 42 per cent in older women, according to a new study. Earlier results have shown similar benefits in men. Omega 3, whose common form in food is Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) can also be taken as a supplement.

16 Mar 2011

ACT receives patent for its single-blastomere technology

Advanced Cell Technology, Inc., a leader in the field of regenerative medicine, announced today that it has been issued a patent on its "single-blastomere" technique. Patent Number 7,893,315 broadly covers ACT's proprietary single-blastomere technology that provides a non-destructive alternative for deriving human embryonic stem cell lines.

23 Feb 2011

Regeneron submits VEGF Trap-Eye BLA to FDA for treatment of wet AMD

Regeneron Pharmaceuticals, Inc. announced that the company submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for VEGF Trap-Eye for the treatment of the neovascular form of age-related macular degeneration (wet AMD). Under the Prescription Drug User Fee Act (PDUFA), the goal for a standard review time from submission to FDA action is ten months.

22 Feb 2011

Early diagnosis can delay or halt progression of macular degeneration

February is Age-related Macular Degeneration and Low Vision Awareness month, providing an opportunity to inform and educate the public on the leading cause of vision loss for adults over the age of 65. Today, over 15 million of these adults suffer from age-related macular degeneration, a number that is expected to grow considerably as the baby boomer generation begins heading into retirement age. While the risks are growing, awareness and education is key to treating and saving the eyesight of millions.

19 Feb 2011

Phase III RISE study of Lucentis for DME meets primary endpoint

Genentech, Inc., a member of the Roche Group, announced today that one of two Phase III studies evaluating monthly Lucentis® (ranibizumab injection) in patients with diabetic macular edema (DME), met its primary endpoint. DME is a serious complication of diabetes that affects up to 10 percent of people with the disease and can lead to blurred vision, severe vision loss and blindness.

14 Feb 2011