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Amgen to discuss application for LUMAKRAS® (sotorasib) for the treatment of KRAS G12C-positive NSCLC at FDA advisory committee meeting

Amgen today announced the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) will review data supporting the supplemental New Drug Application (sNDA) for the full approval of LUMAKRAS® (sotorasib) for adults with previously treated locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC) at a meeting on Oct. 5, 2023.

From AMGEN 1 Sep 2023

Non-alcoholic steatohepatitis progression blocked by ginger essential oil

Researchers explore the potential utility of ginger essential oil in preventing NASH.

29 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Study identifies an endogenous bile acid that alleviates non-alcoholic fatty liver disease

A study finds that hyodeoxycholic acid alleviates non-alcoholic fatty liver disease by modulating the gut-liver axis.

22 Aug 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

Effects of COVID-19 quarantine on outcomes in individuals with intrahepatic cholestasis of pregnancy

The effects of COVID-19 quarantine on outcomes in individuals with intrahepatic cholestasis of pregnancy.

9 Aug 2023

Sperm packaging proteins may hold key to male infertility

Sperm play a critical role in the creation of new life, delivering essentially half of the genetic material required.

31 Jul 2023

Study shows that anti-PTM antibodies are often present in autoimmune mediated liver disease

A recent study published in Frontiers in Medicine described anti-post-translational modification (PTM) antibodies in patients with autoimmune-mediated and cholestatic liver diseases (AILD).

31 Jul 2023

The relationships between risk factors and kidney events in two diabetic cohorts

Researchers use the association rule to assess chronic kidney disease risk in the General and Worker diabetes populations.

25 Jul 2023

Are antidrug antibodies reducing the effectiveness of rheumatoid arthritis treatment?

Researchers examined the association between antidrug antibodies and the response to treatments for rheumatoid arthritis.

17 Jul 2023

The Lancet study unveils exciting findings on retatrutide as a novel treatment for type 2 diabetes

Researchers performed a phase II randomized clinical trial (RCT).

29 Jun 2023

Shaping the human metabolome: the impact of a ketogenic diet

Researchers explored how the human metabolic fingerprint changes with a ketogenic diet (KD).

6 Jun 2023

Study reveals type 2 diabetes diagnosis spurs cholesterol shifts, alters cardiovascular risk

A recent study published in the journal Scientific Reports assessed the associations between the change in total cholesterol (TC) levels after type 2 diabetes (T2D) diagnosis (relative to pre-diagnosis levels) and the risk of cardiovascular disease (CVD).

26 May 2023

Mutation in a ribosomal protein leads to impaired cardiac contractility in mice

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

19 May 2023

Ketogenic diet: A metabolic makeover boosting immunity and battling inflammation

A recent study discusses alterations in the human metabolic fingerprint associated with the keto diet.

8 May 2023

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

Researchers evaluated metabolic profile changes of the skin in relation to microbiota and UV exposure.

5 May 2023

Bee venom nanoparticles: Buzzworthy breakthrough in battling antibiotic-resistant bacteria

Study aimed to test the antibacterial and cytotoxic effects of bee venom-loaded chitosan nanoparticles (BV-loaded CS-NPs) against Staphylococcus aureus. The results showed that BV-loaded CS-NPs had enhanced antibacterial activity and minimal cytotoxicity, making it a promising antibiotic alternative.

24 Apr 2023

What are the frequency and risk of adverse events developing in patients with epilepsy who are using CBD?

Researchers evaluated epilepsy patients to evaluate cannabidiol use-related adverse events.