Aldosterone News and Research

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Aldosterone is a steroid hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps control the balance of water and salts in the kidney by keeping sodium in and releasing potassium from the body. Too much aldosterone can cause high blood pressure and a build-up of fluid in body tissues. Aldosterone is a type of mineralocorticoid hormone.

U-M Professor to review data from three prominent studies on heart failure

Roughly 5 million people in the United States live with heart failure, a condition in which the heart is unable to pump blood around the body effectively. The causes and types of heart failure vary greatly, and treatment must be tailored to each patient. In some cases, doctors will prescribe a class of diuretic drugs called aldosterone antagonists.

20 Sep 2011

Individuals without ubiquitin ligase Nedd4L more likely to develop CF

Cystic fibrosis (CF), a chronic disease that clogs the lungs and leads to life-threatening lung infections, is caused by a genetic defect in a chloride channel called cystic fibrosis transmembrane conductase regulator.

20 Sep 2011

UNC researchers develop technique that can observe cellular intricacies of CF

When researchers discovered the primary genetic defect that causes cystic fibrosis (CF) back in 1989, they opened up a new realm of research into treatment and a cure for the disease. Since then, scientists have been able to clone the defective gene and study its effects in animals. Now researchers at the University of North Carolina at Chapel Hill have developed a technique for observing the defects at work in human tissue donated by patients with CF.

20 Sep 2011

High dietary salt intake and obesity together trigger abnormal activation of cellular protein

Dietary salt intake and obesity are two important risk factors in the development of high blood pressure. Each packs its own punch, but when combined, they deliver more damage to the heart and kidneys than the sum of their individual contributions.

19 Sep 2011

Scientists identify 28 blood pressure-associated genetic variants

A new report from scientists at Massachusetts General Hospital (MGH) and their colleagues in centers around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients.

12 Sep 2011

APS sponsors 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels

The American Physiological Society is sponsoring the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 at the Asilomar Conference Grounds in Pacific Grove, Calif. This scientific conference explores the connection between fluid balance in the body and hypertension, a growing global health concern.

8 Sep 2011

Conference to focus on connection between fluid balance and hypertension

Each day we consume liquids in order to keep hydrated and maintain our body's fluid balance. But just as a water balloon can get overtaxed by too much liquid, the human body is negatively affected when it retains fluids because it is unable to eliminate them properly. One of the key variables influencing how much fluid we hold in our bodies is ordinary table salt.

3 Aug 2011

Sorbent expands $36M Series B financing

Sorbent Therapeutics, a private biopharmaceutical company developing therapies for cardiovascular and renal disorders, announced today that it has expanded the Company's Series B financing from September 2010 by $36 million.

30 Jun 2011

Relypsa initiates dosing in RLY5016 Phase 2b trial for hyperkalemia in diabetic nephropathy and CKD patients

Relypsa, Inc. today announced the start of dosing in a Phase 2b clinical trial of RLY5016 for the treatment of hyperkalemia in patients with diabetic nephropathy and chronic kidney disease (CKD). RLY5016 is a high capacity, non-absorbed, polymer-based potassium binder that is orally administered and has been shown to control serum potassium levels in previous studies.

28 Jun 2011

Study finds high prevalence of diabetic kidney disease in the U.S.

Over the past 2 decades the prevalence of diabetic kidney disease in the U.S. increased in direct proportion to the prevalence of diabetes itself, according to a study in the June 22/29 issue of JAMA.

22 Jun 2011

Key heart failure therapies could prevent nearly 68,000 deaths each year

A national study has found that nearly 68,000 deaths potentially could be prevented each year by optimally implementing key national guideline-recommended therapies, including critical medications and cardiac devices, for all eligible heart failure patients.

7 Jun 2011

Positive results from Relypsa RLY5016 Phase 2 trial to be presented at American Society of Hypertension meeting

Relypsa, Inc. today announced the presentation of positive results from a Phase 2 clinical trial of the company's lead compound, RLY5016, a non-absorbed oral potassium binder being developed as a treatment for hyperkalemia (elevated serum potassium levels).

23 May 2011

Eplerenone reduces new onset atrial fibrillation and flutter in patients with class 2 heart failure

The aldosterone antagonist eplerenone significantly reduced the development of new onset atrial fibrillation and flutter in patients with class 2 heart failure, concludes a sub-analysis of the EMPHASIS-HF trial, presented at the Heart Failure Congress 2011, organized by the Heart Failure Association of the European Society of Cardiology.

23 May 2011

$Study: Only 15% of heart failure patients with spinal fractures are being treated for osteoporosis$

Study: Only 15% of heart failure patients with spinal fractures are being treated for osteoporosis

One in 10 heart failure patients had compression fractures in the spine that could have been detected by a chest X-ray, but few are receiving treatment to help prevent such fractures according to a Canadian study published in the American Heart Association journal Circulation: Heart Failure.

11 May 2011

Confusing research on salt and heart: Study

According to the latest European study, people who ate lots of salt were not more likely to get high blood pressure, and were less likely to die of heart disease than those with a low salt intake. This is contrary to what has been known till date. The U.S. guidelines recommend that Americans consume less than 2,300 milligrams of salt daily - 1,500 mg in certain people who are more at risk for high blood pressure or heart disease.

4 May 2011

Bayer's oral contraceptives may increase risk of blood clots, stroke or heart attack

Bayer HealthCare Pharmaceuticals, Inc. is aware of two studies published today in The British Medical Journal, ONLINE FIRST.

25 Apr 2011

Adherence to guideline-related therapies can reduce heart failure patients' mortality rate

A UCLA-led study has found that adherence to national guideline-recommended therapies for heart failure in an outpatient practice setting significantly lowered the mortality rate of heart failure patients.

5 Apr 2011

Study finds increased risk of VTE during first year of combination oral contraceptive usage

Bayer HealthCare Pharmaceuticals Inc. today announced that interim results from a large, prospective, observational cohort safety study offer insights into the increased risk of venous thromboembolism (VTE), or blood clots, which is a well-established risk in women who use combination oral contraceptives (COCs), also known as "the Pill".

25 Mar 2011

IQWiG publishes results of search update for evidence-based clinical practice guidelines on CHD

On 7 February 2011, the German Institute for Quality and Efficiency in Health Care published the results of a search update for evidence-based clinical practice guidelines on coronary heart disease.

17 Feb 2011

Patients with high blood pressure have benign endocrine tumours in adrenal gland: Research

High blood pressure may in some cases be caused by benign hormone-producing tumours of the adrenal cortex. A joint Swedish-American research effort has now uncovered a genetic cause behind the occurrence of such tumours. The findings were published today in the journal Science.

11 Feb 2011

Aldosterone News and Research

U-M Professor to review data from three prominent studies on heart failure

Individuals without ubiquitin ligase Nedd4L more likely to develop CF

UNC researchers develop technique that can observe cellular intricacies of CF

High dietary salt intake and obesity together trigger abnormal activation of cellular protein

Scientists identify 28 blood pressure-associated genetic variants

APS sponsors 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels

Conference to focus on connection between fluid balance and hypertension

Sorbent expands $36M Series B financing

Relypsa initiates dosing in RLY5016 Phase 2b trial for hyperkalemia in diabetic nephropathy and CKD patients

Study finds high prevalence of diabetic kidney disease in the U.S.

Key heart failure therapies could prevent nearly 68,000 deaths each year

Positive results from Relypsa RLY5016 Phase 2 trial to be presented at American Society of Hypertension meeting

Eplerenone reduces new onset atrial fibrillation and flutter in patients with class 2 heart failure

Study: Only 15% of heart failure patients with spinal fractures are being treated for osteoporosis

Confusing research on salt and heart: Study

Bayer's oral contraceptives may increase risk of blood clots, stroke or heart attack

Adherence to guideline-related therapies can reduce heart failure patients' mortality rate

Study finds increased risk of VTE during first year of combination oral contraceptive usage

IQWiG publishes results of search update for evidence-based clinical practice guidelines on CHD

Patients with high blood pressure have benign endocrine tumours in adrenal gland: Research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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