Amyloid Plaque News and Research

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Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

A class of Alzheimer's disease drugs currently studied in clinical trials appears to reduce damage caused by traumatic brain injury in animals, researchers at Georgetown University Medical Center report in an upcoming advance online publication of Nature Medicine.

15 Mar 2009

Alzheimer's marker amyloid beta 42 linked to brain damage

Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

11 Mar 2009

Brain damage found in cognitively normal people with Alzheimer's marker

Researchers at Washington University School of Medicine in St. Louis have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment.

11 Mar 2009

Amyloid plaques may increase the activity of astrocytes

The impact of the amyloid plaques that appear in the brains of patients with Alzheimer's disease may extend beyond the deposits' effects on neurons – the cells that transmit electrochemical signals throughout the nervous system.

26 Feb 2009

Forgotten and lost -- when proteins 'shut down' our brain

Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry (Göttingen) and the Max Planck Unit for Structural Molecular Biology (Hamburg) with the help of Nuclear Magnetic Resonance Spectroscopy ( PLoS Biology , February 17, 2009).

18 Feb 2009

New nationwide Alzheimer's study underway

Researchers at Wake Forest University Baptist Medical Center are preparing to begin a clinical trial aimed at testing an investigational new drug that may help control the progression of Alzheimer's disease.

17 Feb 2009

New method to stimulate immune system may be effective at reducing amyloid burden in Alzheimer?s

Researchers at NYU Langone Medical Center have discovered a novel way to stimulate the innate immune system of mice with Alzheimer's disease (AD) - leading to reduced amyloid deposits and the prevention of Alzheimer's disease related pathology - without causing toxic side effects.

15 Feb 2009

DREAM gene found to be a genetic candidate for explaining old age dementia

In 2002, a group of scientists at the University of Toronto was able to identify a gene which they dubbed DREAM (downstream regulatory element antagonistic modulator).

19 Jan 2009

Diabetes associated with different types of brain injury in patients with dementia

Patients with dementia and diabetes appear to display a different pattern of injuries in their brains than patients with dementia but without diabetes, according to an article posted online today that will appear in the March print issue of Archives of Neurology.

12 Jan 2009

Innovative brain-scan technology helps visualize brain aging before symptoms appear

UCLA scientists have used innovative brain-scan technology developed at UCLA, along with patient-specific information on Alzheimer's disease risk, to help diagnose brain aging, often before symptoms appear.

6 Jan 2009

Scientists create infectious prion disease in mouse model

A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals.

8 Dec 2008

Study looks at investigational compound MK-677 in Alzheimer's disease

A new study shows that a drug that increases the release of growth hormone failed to slow the rate of progression of Alzheimer's disease in humans.

17 Nov 2008

Education delays onset of the dementia

A test that reveals brain changes believed to be at the heart of Alzheimer's disease has bolstered the theory that education can delay the onset of the dementia and cognitive decline that are characteristic of the disorder.

10 Nov 2008

Greater thinking, learning and memory abilities delay symptoms of Alzheimer's disease

Individuals with higher education levels appear to score higher on cognitive tests despite having evidence of brain plaques associated with Alzheimer's disease, according to a report in the November issue of Archives of Neurology , one of the JAMA/Archives journals.

10 Nov 2008

Education lessens the effects of Alzheimer's

The scientists from the Washington University School of Medicine, St. Louis, say their research supports the 'cognitive reserve' hypothesis and individuals with levels of higher education levels score higher on cognitive tests despite having Alzheimer's disease.

10 Nov 2008

Self assembling "organic wires"

From pacemakers constructed of materials that so closely mimic human tissues that a patient's body can't discern the difference to devices that bypass injured spinal cords to restore movement to paralyzed limbs, the possibilities presented by organic electronics read like something from a science fiction novel.

23 Oct 2008

The Internet stimulates and possibly improves brain function

UCLA scientists have found that for computer-savvy middle-aged and older adults, searching the Internet triggers key centers in the brain that control decision-making and complex reasoning. The findings demonstrate that Web search activity may help stimulate and possibly improve brain function.

14 Oct 2008

Markers in blood and spinal fluid, and a new imaging agent, show promise for early detection of Alzheimer's

With the continued aging of the population and the growing epidemic of Alzheimer's, early detection of the disease is crucial for risk assessment, testing new therapies, and eventual early intervention with better drugs, once they are developed. Four studies reported today at the Alzheimer's Association's 2008 International Conference on Alzheimer's Disease (ICAD 2008) in Chicago bring us closer to that goal of early detection by describing advances in biomarkers.

29 Jul 2008

New Alzheimer's studies show advances against different treatment targets

Two studies related to experimental Alzheimer's therapies reported positive results today at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2008) in Chicago.

28 Jul 2008

Amyloid plaques seen with conventional MRI in animal model for first time

For the first time, scientists have captured images of brain lesions similar to those found in Alzheimer's disease using clinical-grade MRI in an animal model of the disease, according to research reported at the Alzheimer's Association's 2008 International Conference on Alzheimer's Disease (ICAD 2008), in Chicago.

27 Jul 2008