Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

New high-throughput assay could help development of anti-COVID-19 drugs

In a recent study, researchers develop a new high-throughput assay that allows for rapid screening of potential inhibitors.

13 Oct 2021

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Researchers review diverse computational methods for drug/inhibitor design and enzymes as potential targets for inhibitors to treat coronaviruses diseases.

12 Oct 2021

Taste loss as a COVID-19 symptom: a review

A new review reports that alterations in taste affected about a third of individuals with a COVID-19 diagnosis, with females being affected more than males.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

A recent study compares the transmissibility of the SARS-CoV-2 Alpha and Delta variants in six states across New England in the United States

11 Oct 2021

An investigation of SARS-CoV-2 infection in diabetic pregnancies

Researchers discuss the basic and clinical science of the potential inter-relationships between diabetes mellitus and COVID-19 in pregnancies.

11 Oct 2021

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

It is demonstrated that palmitoylation of the first five cysteine residues of the C-terminal domain of the SARS-CoV-2 spike protein facilitates cell entry and the formation of syncytia.

11 Oct 2021

Delta variant exhibits immune evasion, enhanced cell entry, and augmented syncytium formation

Researchers addressed the question of using reporter particles pseudotyped with the S protein of SARS-CoV-2, which are suitable tools to examine SARS-CoV-2 neutralization antibodies.

11 Oct 2021

Prior immunity to influenza, not SARS-CoV-2, prevents severe disease and mortality

Researchers from the Israel Institute of Biological Research delineated the interplay between IAV and SARS CoV-2 infections.

11 Oct 2021

The neurological effects of COVID-19

What is the relationship between COVID-19 and the brain? A new review published in Tropical Biomedicine summarizes the key findings on how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe COVID-19 infection, disrupts brain activity and produces a range of long-term neurological disorders.

10 Oct 2021

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

The results of Phase I clinical trials for two new COVID-19 vaccine candidates based on recombinant RDB proteins are reported.

10 Oct 2021

What impact does temperature have on SARS-CoV-2 M protein dynamics?

In a recent study, the structural dynamics of the SARS-CoV-2 M protein are studied at temperatures of 10-50 ˚C using molecular dynamics simulations.

10 Oct 2021

Lipids, COVID-19, and host immunity

A new study from a team of researchers at the University of Pennsylvania examines the role played by lipids in this disease.

10 Oct 2021

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

A new paper discusses a new antibody with potent neutralizing activity against the ancestral SARS-CoV-2 strain, as well as newer variants of SARS-CoV-2.

10 Oct 2021

Role of S-acylation in SARS-CoV-2 infectivity

A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.

10 Oct 2021

mRNA vaccination associated with decreased risk of COVID-19 infection and hospitalization in U.S. veterans

Researchers from the U.S. Veterans Affairs have examined the U.S. effort to vaccinate its Veteran population to investigate further.

8 Oct 2021

Assay to assess and quantify presence of RBD-directed antibodies against SARS-CoV-2 following vaccination

Researchers from Roche Diagnostics have been testing a new assay known as the Elecsys assay.

8 Oct 2021

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Researchers from Ohio State University have been investigating mutations in the rest of the spike protein, particularly the Q677H mutation.

7 Oct 2021

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Scientists have developed and validated a cell-free fluorescence assay for the rapid screening of protein inhibitors.

7 Oct 2021

Graphene biosensor in a portable and wireless device for rapid SARS-CoV-2 detection

A new study posted to the medRxiv* server and led by Dr. Mattia D'Agostino, Dr. Eleonora Pavoni and Dr. Alice Romagnoli from the Polytechnic University of Marche in Ancona (Italy), a gFET biosensor that uses angiotensin-converting enzyme 2 (ACE2) as a bioreceptor has been put forth as a viable solution.

6 Oct 2021

Angiotensin News and Research

Further Reading

New high-throughput assay could help development of anti-COVID-19 drugs

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Taste loss as a COVID-19 symptom: a review

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

An investigation of SARS-CoV-2 infection in diabetic pregnancies

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

Delta variant exhibits immune evasion, enhanced cell entry, and augmented syncytium formation

Prior immunity to influenza, not SARS-CoV-2, prevents severe disease and mortality

The neurological effects of COVID-19

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

What impact does temperature have on SARS-CoV-2 M protein dynamics?

Lipids, COVID-19, and host immunity

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

Role of S-acylation in SARS-CoV-2 infectivity

mRNA vaccination associated with decreased risk of COVID-19 infection and hospitalization in U.S. veterans

Assay to assess and quantify presence of RBD-directed antibodies against SARS-CoV-2 following vaccination

non-RBD mutation in SARS-CoV-2 variants enhances resistance to neutralizing antibodies

Scientists develop a cell-free assay to screen SARS-CoV-2 entry inhibitors

Graphene biosensor in a portable and wireless device for rapid SARS-CoV-2 detection

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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