Angiotensin Converting Enzyme 2 News and Research

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Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Researchers identified an ultralong bovine antibody that neutralizes SARS-CoV-2 and SARS-CoV.

11 Apr 2022

Study explores phytochemical-based antivirals against SARS-CoV-2 infection

A new study depicted plant-based biologically active antiviral agents that are effective against SARS-CoV-2 infection.

11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

Computational network science approach reveals new mechanisms for coronaviruses infections

A group of bat viruses related to SARS-CoV-2 can also infect human cells but uses a different and unknown entryway.

8 Apr 2022

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

A new study demonstrated that vascular inflammation leads to heightened SARS-CoV-2 infection in perivascular cells.

8 Apr 2022

UGA researchers develop nanotechnology-based optical sensors for rapid coronavirus detection

A University of Georgia nanotechnology research group entered the race to develop a rapid test for COVID-19 in August 2020, running experiments on a new sensor for an American manufacturing company.

7 Apr 2022

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model.

7 Apr 2022

Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions

A recent study posted to the medRxiv* preprint server investigated the association of renin-angiotensin-aldosterone system (RAAS)-mediated hypertension (HT) with coronavirus disease 2019 (COVID-19).

6 Apr 2022

COVID boosters protect you better than monoclonal antibodies, or natural infection

In a new study published in the journal Science Translational Medicine, researchers analyzed the neutralization of the Omicron BA.1 variant pseudovirus by post-vaccination serum samples.

6 Apr 2022

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Researchers identified breakthrough infections by Omicron sublineages BA.1, BA.1.1, and BA.2 in triple-vaccinated healthcare workers of Sweden.

6 Apr 2022

Self-assembling SARS-CoV-2 spike protein-directed nanoparticle vaccines

A new preprint study depicted the generation of self-assembling coronavirus disease 2019 (COVID-19) nanoparticle vaccines.

6 Apr 2022

Study evaluates the presence of the SARS-CoV-2 spike protein in urine samples collected during the COVID-19 pandemic

A study published analyzed the presence of SARS-CoV-2 spike protein in urine samples of the infected patients.

6 Apr 2022

Researchers identify novel SARS-CoV-2 Delta-Omicron recombinant strain in Europe

A new study presented the rapid profiling of a SARS-CoV-2 Delta-Omicron recombinant sequence from Europe.

6 Apr 2022

Study highlights immune escape mutations in viral N-terminal domain supersite of SARS-CoV-2 spike variants

Researchers characterized SARS-CoV-2 spike (S) isolates extracted from the samples of two individuals infected with the virus in Peru (ΔN25) and Brazil (ΔN135) in January 2021.

6 Apr 2022

Investigating extensive SARS-CoV-2 neutralizing immunoglobulins from COVID-19 recovered subjects

A new study discovered immunoglobulins with powerful broad-acting neutralizing capacity against SARS-CoV-2 from SARS-CoV-2 convalescents.

5 Apr 2022

Prior COVID vaccination induces a more robust antibody response to Omicron

A recent study posted to the medRxiv* preprint server assessed the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on the human immune response against SARS-CoV-2 Omicron infection.

5 Apr 2022

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

Researchers investigated the effect of repeated alcohol exposure and withdrawal on angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, putative regulators of SARS-CoV-2 entry, in discrete brain regions.

4 Apr 2022

Customized digital alert improves guideline-directed medical therapy for heart failure

Physicians prescribed significantly more guideline-directed medications for heart failure if they received a customized digital alert via an electronic health record (EHR) system when inputting medical orders shortly after seeing a patient, according to a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Angiotensin Converting Enzyme 2 News and Research

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Study explores phytochemical-based antivirals against SARS-CoV-2 infection

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Computational network science approach reveals new mechanisms for coronaviruses infections

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

UGA researchers develop nanotechnology-based optical sensors for rapid coronavirus detection

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions

COVID boosters protect you better than monoclonal antibodies, or natural infection

Investigating high rate of Omicron sublineage breakthrough infections in triple vaccinated healthcare workers

Self-assembling SARS-CoV-2 spike protein-directed nanoparticle vaccines

Study evaluates the presence of the SARS-CoV-2 spike protein in urine samples collected during the COVID-19 pandemic

Researchers identify novel SARS-CoV-2 Delta-Omicron recombinant strain in Europe

Study highlights immune escape mutations in viral N-terminal domain supersite of SARS-CoV-2 spike variants

Investigating extensive SARS-CoV-2 neutralizing immunoglobulins from COVID-19 recovered subjects

Prior COVID vaccination induces a more robust antibody response to Omicron

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

Customized digital alert improves guideline-directed medical therapy for heart failure

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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