Angiotensin Converting Enzyme 2 News and Research

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Exploring Oxford nanopore technology-based on-site SARS-CoV-2 genome sequencing

In a new study, researchers performed genomic sequencing of SARS-CoV-2-infected samples and aimed to identify the dominant variant, assess the mutation profile, and determine the sample-to-sequence turnover time.

1 Mar 2022

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

In a new study, researchers used deep transcriptome analysis to examine the coding and non-coding transcriptional landscape of lung cells infected with SARS-CoV-2.

1 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Researchers investigated protein interactions of SARS-CoV-2 with host and viral RNAs in infected cells.

1 Mar 2022

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers assessed the immunogenicity of the self-developed recombinant adenovirus vector (rAd5) vaccine on macaques. They evaluated the efficacy of three candidate vaccines, ED88, ED90, and ED94, to select the most appropriate one for future development.

1 Mar 2022

Biophysical fitness profile of SARS-CoV-2 Delta variant

In a recent study posted to the bioRxiv* preprint server, researchers investigated the biophysical fitness landscape of the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

1 Mar 2022

COVID-19 severity is correlated with body composition

In a recent study posted to the medRxiv* preprint server, researchers assessed the effect of changes in the abdominal well-being and physique on coronavirus disease 2019 (COVID-19) severity using magnetic resonance imaging (MRI).

28 Feb 2022

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

A recent study evaluated the molecular and histopathological effects in the placenta following a SARS-CoV-2 infection during pregnancy.

28 Feb 2022

Molecular insights on the possible connection of SARS-CoV-2 and nicotinic acetylcholine receptors

A recent study assessed the mechanism by which SARS-CoV-2 Omicron and Alpha VOCs inhibit the SARS-CoV-2 spike protein and mitigate the risk of a multisystem inflammatory syndrome in children.

28 Feb 2022

Study finds lower prevalence of post-acute SARS-CoV-2 symptomology in vaccinated individuals

In a recent study, researchers evaluated the effect of COVID-19 vaccines on the symptomatic prevalence of SARS-CoV-2 infections beyond the acute phase of the disease.

28 Feb 2022

Triple antibody cocktail is a promising candidate for immunotherapy against SARS-CoV-2 variants of concern

Researchers generated a panel of bnAbs against SARS-CoV, SARS-CoV-2, and its variant VOCs, including Omicron from sequentially immunized mice.

28 Feb 2022

Will Omicron BA.2 become the next dominant variant?

A new study presents a comprehensive analysis of the potential of both Omicron BA.2 and BA.3 to become the next dominant circulating SARS-CoV-2 strain.

27 Feb 2022

Emergence of SARS-CoV-2 Omicron likely due to immune selective pressure

A new study discusses the emergence of new variants of SARS-CoV-2 that can escape antibody-mediated neutralization, as opposed to other Sarbecoviruses.

27 Feb 2022

Altered microbiomes in SARS-CoV-2 infection pose threat of antibiotic resistance

A new study discusses changes in the microbiota of various parts of the body with SARS-CoV-2 infection.

27 Feb 2022

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Researchers examined systemic B and T cell responses 16 weeks after BNT162b2 vaccination, and the potency of vaccine-induce neutralizing antibodies, in hemodialysis patients and healthcare workers with no comorbidities.

25 Feb 2022

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

Researchers investigated whether residual SARS-CoV-2 antigens and RNA are present in tissues samples of long COVID-19 patients beyond the convalescent phase of COVID-19.

24 Feb 2022

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Researchers examined how SARS-CoV-2 variants of concern differentially use an additional metalloproteinase-dependent entry pathway to enter the host cells.

24 Feb 2022

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

Researchers developed a hybrid assay incorporating immunological antibody-based viral spike protein capture with molecular nucleic acid amplification by qRT-PCR.

24 Feb 2022

White blood cell count as a prognostic indicator of COVID-19

Based on a new study, researchers concluded WBC count variations worsen clinical outcomes such as severity, mortality, and hospital discharge rates leading to a poorer prognosis in COVID-19 patients.

23 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

Angiotensin Converting Enzyme 2 News and Research

Exploring Oxford nanopore technology-based on-site SARS-CoV-2 genome sequencing

Analyzing transcriptomic landscape of SARS-CoV-2-infected lung cells

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

Biophysical fitness profile of SARS-CoV-2 Delta variant

COVID-19 severity is correlated with body composition

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

Molecular insights on the possible connection of SARS-CoV-2 and nicotinic acetylcholine receptors

Study finds lower prevalence of post-acute SARS-CoV-2 symptomology in vaccinated individuals

Triple antibody cocktail is a promising candidate for immunotherapy against SARS-CoV-2 variants of concern

Will Omicron BA.2 become the next dominant variant?

Emergence of SARS-CoV-2 Omicron likely due to immune selective pressure

Altered microbiomes in SARS-CoV-2 infection pose threat of antibiotic resistance

Declining immune responses against SARS-CoV-2 variants in dialysis patients post-vaccination

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

White blood cell count as a prognostic indicator of COVID-19

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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