Animal Model News and Research

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A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Researchers provide evidence that a novel vaccine candidate robustly neutralized SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.

16 Mar 2023

Lassa virus vaccine induces rapid protection in an animal model

Scientists have developed a novel Lassa vaccine using a recombinant measles virus and tested its protective efficacy against Lassa fever. A single vaccine dose has been found to induce a rapid and robust immune response in monkeys with pre-existing immunity against the measles virus.

14 Mar 2023

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

A small protein could provide a revolutionary approach to tackling obesity-related diseases

Research published today shows that a peptide (small protein) called PEPITEM could provide a revolutionary approach to reducing the risk of type 2 diabetes and other obesity-related diseases such as hepatic steatosis (fatty liver).

9 Mar 2023

Researchers develop a 100%-effective mRNA vaccine for deadly bacteria

For the first time in the world: a team of researchers from Tel Aviv University and the Israel Institute for Biological Research have developed an mRNA-based vaccine that is 100% effective against a type of bacteria that is lethal to humans.

9 Mar 2023

New technique helps surgeons reconstruct more natural-looking nipples after mastectomy

Weill Cornell Medicine investigators have developed a technique to help surgeons reconstruct more natural-looking nipples for patients who have undergone breast reconstruction after mastectomy to treat breast cancer.

9 Mar 2023

Mutant mice models created for studying bipolar disorder

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes).

7 Mar 2023

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects.

6 Mar 2023

Promising alternative strategy for islet transplantation in people with type 1 diabetes

In people with type 1 diabetes, the body's immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets.

1 Mar 2023

Novel software tool helps analyze animal behaviors

A team from the University of Michigan has developed a new software tool to help researchers across the life sciences more efficiently analyze animal behaviors.

25 Feb 2023

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

CÚRAM SFI Research Centre for Medical Devices researchers have published in Nature Communications a key study establishing a new pre-clinical model to develop clinically relevant treatments for heart attacks.

24 Feb 2023

First-of-its-kind wireless, battery-free bandage accelerates wound healing

Northwestern University researchers have developed a first-of-its-kind small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site.

22 Feb 2023

RBD-NTD-subunit protein vaccine provides a promising booster vaccination strategy capable of protecting against known SARS-CoV-2 variants

Researchers assessed the impact of SARS-CoV-2 spike NTD incorporation into the RBD protein vaccine.

22 Feb 2023

Alternative splicing plays a role in compensating for loss of gene function

Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs.

21 Feb 2023

Fetal cell program appears to protect against acute myeloid leukemia

During the fetal stage, a number of so-called cell programs run that are vital to the development of the fetus.

21 Feb 2023

Mongolian gerbil with an ear structure could help better understand a type of “third window syndrome”

To patients of P. Ashley Wackym, a surgical otologist-neurotologist at Rutgers Robert Wood Johnson Medical School, a diagnosis of superior semicircular canal dehiscence (SSCD) can feel like a death sentence.

17 Feb 2023

Elevated level of α-synuclein aggregates in stool samples can indicate early form of Parkinson’s

The so-called isolated REM-sleep behavior disorder is a condition that can provide an indication of Parkinson's disease well in advance.

16 Feb 2023

Novel experimental platform optically records neuronal activity during brain-wide fMRI in rodents

When we daydream or revisit memories, a large group of regions within our brain "lights up," or becomes more active.

16 Feb 2023

New mouse model demonstrates clear differences in virulence among mpox virus clades

Scientists from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health have removed a major roadblock to better understanding of mpox (formerly, monkeypox).

14 Feb 2023

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Those with Usher Syndrome -- the leading hereditary cause for simultaneous deafness and blindness, for which there is no treatment -- may have a new reason for hope now that researchers have confirmed the first-ever nonhuman primate model of their disease.

13 Feb 2023

Animal Model News and Research

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Lassa virus vaccine induces rapid protection in an animal model

New genetic animal model may inform potential therapeutic options for Down syndrome

A small protein could provide a revolutionary approach to tackling obesity-related diseases

Researchers develop a 100%-effective mRNA vaccine for deadly bacteria

New technique helps surgeons reconstruct more natural-looking nipples after mastectomy

Mutant mice models created for studying bipolar disorder

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

Promising alternative strategy for islet transplantation in people with type 1 diabetes

Novel software tool helps analyze animal behaviors

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

First-of-its-kind wireless, battery-free bandage accelerates wound healing

RBD-NTD-subunit protein vaccine provides a promising booster vaccination strategy capable of protecting against known SARS-CoV-2 variants

Alternative splicing plays a role in compensating for loss of gene function

Fetal cell program appears to protect against acute myeloid leukemia

Mongolian gerbil with an ear structure could help better understand a type of “third window syndrome”

Elevated level of α-synuclein aggregates in stool samples can indicate early form of Parkinson’s

Novel experimental platform optically records neuronal activity during brain-wide fMRI in rodents

New mouse model demonstrates clear differences in virulence among mpox virus clades

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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