Animal Model News and Research

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Feline virus, antiviral drug studied to understand drug resistance

Researchers at Ohio State will spend the next two years testing their theories about just how an AIDS-like virus in cats is able to resist the powerful medicines that are thrown against it.

10 Oct 2007

First animal model of age-related macular degeneration

Researchers at the University of Pennsylvania School of Medicine have created the first animal model of age-related macular degeneration (AMD) caused by a mutation known to produce disease in people, an important first step in developing treatments.

10 Oct 2007

Injectable antibody reverses cognitive deficits in mice

A special protein can be injected into the body to reverse learning problems in mice that have an animal version of Alzheimer's disease, Saint Louis University researchers have found.

9 Oct 2007

Specific immune deficiency pinpointed as likely cause of ulcerative colitis

In a series of mouse experiments, researchers at the Harvard School of Public Health (HSPH) have pinpointed a specific immune deficiency as the likely fundamental cause of ulcerative colitis, a chronic, sometimes severe inflammatory disease of the colon or large intestine that afflicts half a million Americans.

4 Oct 2007

Probiotic bacteria improve diarrhea in infants

Each year more than half a million infants worldwide, primarily in developing countries, die from diarrhoea caused by rotavirus.

27 Sep 2007

Novel strategy to tackle acute myelogenous leukemia

A novel strategy to hopefully beat into oblivion one of the most aggressive forms of acute myelogenous leukemia combines the strengths of some of the newest leukemia agents, researchers say.

25 Sep 2007

FAU receives patent for invention that induces and restores cardiac muscle function

Florida Atlantic University received U.S. patent no. 10/822,496, "Promoting Cardiac Cell Differentiation," based on an invention which induces and restores cardiac muscle function.

24 Sep 2007

New patented invention induces and restores cardiac muscle function

Florida Atlantic University received U.S. patent no. 10/822,496, "Promoting Cardiac Cell Differentiation," based on an invention which induces and restores cardiac muscle function.

21 Sep 2007

Process of necrosis redefined in landmark study

A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path.

21 Sep 2007

Re-engineered human T cells effectively target and kill cancerous B cells

Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia (ALL), according to researchers at Memorial Sloan-Kettering Cancer Center (MSKCC).

18 Sep 2007

Breakthrough in cardiovascular research

Cholesterol contributes to atherosclerosis - a condition that greatly increases the risk of heart attack and stroke - by suppressing the activity of a key protein that protects the heart and blood vessels, researchers at the Saint Louis University School of Medicine have found.

18 Sep 2007

Cell death in sparrow brains may provide clues in age-related human diseases

A remarkable change takes place in the brains of tiny songbirds every year, and some day the mechanism controlling that change may help researchers develop treatments for age-related degenerative diseases of the brain such as Parkinson's and dementia.

18 Sep 2007

Potential vaccine target for chlamydia

Scientists at Children's Hospital of Pittsburgh of UPMC have identified a potential target for the development of a vaccine against Chlamydia trachomatis, the most prevalent sexually transmitted bacterial infection in the world.

13 Sep 2007

Disease activity increases after multiple sclerosis patients stop natalizumab

People with multiple sclerosis who stop taking the drug natalizumab may experience a rebound increase in disease activity, according to a study published September 12, 2007, in the online edition of Neurology, the medical journal of the American Academy of Neurology.

13 Sep 2007

New clues to cracking brain's neural code

Decoding the complex electrical signals that brain cells use to "talk" to each other is a new and important frontier in neuroscience, one that could revolutionize the diagnosis and treatment of neurological and psychiatric disease.

12 Sep 2007

Customized virus kills brain tumor stem cells that drive lethal cancer

A tailored virus destroys brain tumor stem cells that resist other therapies and cause lethal re-growth of cancer after surgery, a research team led by scientists at the University of Texas M. D. Anderson Cancer Center reports in the Sept. 18 edition of the Journal of the National Cancer Institute.

12 Sep 2007

New approaches to transcutaneous electrical nerve stimulation studied

Current post-operative pain control methods have proved inadequate for those who have undergone total knee replacement (TKR), according to University of Iowa College of Nursing researcher.

11 Sep 2007

Discovery of tendon cells that self-renew

Athletes know that damage to a tendon can signal an end to their professional careers. But a consortium of scientists, led in part by USC School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics - including the ability to proliferate and self-renew.

10 Sep 2007

Mutated mice provide new insights into autism

Mice containing a mutated human gene implicated in autism exhibit the poor social skills but increased intelligence akin to the title character's traits in the movie “Rain Man,” researchers at UT Southwestern Medical Center have found.

10 Sep 2007

Radiation and drug combo helps boost efficacy of lung-cancer treatment

Combining radiation therapy with a drug that helps destroy blood vessels nourishing malignant tumors has been shown in mice to be significantly more effective in treating lung cancer than either approach alone, researchers at UT Southwestern Medical Center have found.

5 Sep 2007