Animal Model News and Research

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Radiation and drug combo helps boost efficacy of lung cancer treatment

Combining radiation therapy with a drug that helps destroy blood vessels nourishing malignant tumors has been shown in mice to be significantly more effective in treating lung cancer than either approach alone, researchers at UT Southwestern Medical Center have found.

3 Sep 2007

Small animal imaging facility is big boon to research

When powerful magnets line up the body's protons before radiofrequency waves can grab their attention away, it's called spin physics.

30 Aug 2007

Impact of mild hearing loss on neurological processes

Mild to moderate forms of hearing loss can have a lasting impact on the auditory cortex, according to findings by researchers at New York University's Center for Neural Science.

30 Aug 2007

Third factor identified in obesity-induced Type 2 diabetes

In cases of Type 2 diabetes, the body's cells fail to appropriately regulate blood glucose levels.

30 Aug 2007

Animal model for dengue research

A mosquito-borne disease often known as "break-bone fever" has found a new enemy in a unique type of mouse.

28 Aug 2007

HSP 90 inhibitors may help ICU patients beat infections

HSP 90 inhibitors, which are finding favor in fighting cancer, may also help battle overwhelming infection in intensive care patients, researchers say.

28 Aug 2007

Potential new strategies for treating obsessive compulsive disorder

Using genetic engineering, researchers have created an obsessive-compulsive disorder (OCD) - like set of behaviors in mice and reversed them with antidepressants and genetic targeting of a key brain circuit.

24 Aug 2007

Vaccine suppresses aggregates of tau protein - implications for Alzheimer's

A new study by NYU Medical Center researchers shows for the first time that the immune system can combat the pathological form of tau protein, a key protein implicated in Alzheimer's disease.

22 Aug 2007

Tumors use enzyme to recruit regulatory T-cells and suppress immune response

One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.

17 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Sirtuin protein instrumental in fat production and metabolism

A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes.

17 Aug 2007

The role of estrogens and polyphenols in hypertension and diabetes

Menopausal women are at relatively high risk for memory loss, high blood pressure (hypertension) and diabetes.

12 Aug 2007

Light-activated molecules used to induce apoptosis in cancer cells

A key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often don't discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance.

12 Aug 2007

Sex hormones play a significant role in the development of diabetic kidney disease

Women have a "female advantage" when it comes to chronic kidney disease. When compared to men, they have fewer and less severe episodes of this disorder throughout most of their lives.

11 Aug 2007

Sex steroids, platelet aggregation and inflammation

In women, hormone therapy is a risk factor for venous thrombosis, a blood clot forming deep inside the vein. Despite the fact that the disorder is rare, it increases exponentially during menopause and can be deadly.

11 Aug 2007

Testosterone replacement therapy for men

For decades, older women have taken hormone replacements to replenish estrogen and progesterone levels lost to aging.

9 Aug 2007

Estrogen deficiency may trigger the development of high blood pressure and obesity in aged females

At menopause, women lose hormone protection against heart (cardiovascular) and kidney (renal) diseases, and are likely to become obese. A research team has tested the idea that estrogen deficiency in aged females may trigger the development of high blood pressure and obesity.

9 Aug 2007