Animal Model News and Research

RSS

New hope for Huntington disease cure

Researchers provide ground-breaking evidence for a cure for Huntington disease in a mouse offering hope that this disease can be relieved in humans.

18 Jun 2006

New research on brain, hormones and behavior

New clinical and basic science research findings focusing on the interaction between hormones and the brain and its influence on behavior will be presented for the first time at the 6th International Congress of Neuroendocrinology.

6 Jun 2006

Exposure to environmental estrogens during development of the prostate gland in the male fetus may lead to later prostate cancer risk

A study in the June 1 issue of Cancer Research presents the first evidence that exposure to low doses of environmental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer later in life.

1 Jun 2006

Finding opens new pathways for treating or preventing autoimmune diseases

A rare genetic defect that can trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease.

31 May 2006

Level of selenium-containing proteins in the body instrumental in preventing cancer

Selenium, an essential dietary mineral that can act as an antioxidant when incorporated into proteins, has been shown in many studies to reduce the incidence of cancers -- notably lung, colorectal and prostate.

23 May 2006

Novel animal model of lung adenocarcinoma

Drs. Katerina Politi, Harold Varmus and colleagues at the Memorial Sloan Kettering Cancer Center in New York have developed a novel animal model of lung adenocarcinoma that will be of great use in testing the efficacy of targeted therapies against human lung cancer.

17 May 2006

German scientists synthesize new compound that reduces stroke damage

A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms.

16 May 2006

First animal model that mimics human head and neck cancer

An Oregon Health & Science University Cancer Institute research laboratory has developed a novel mouse model designed specifically to study the often devastating head and neck squamous cell cancers.

16 May 2006

New technique for freezing and preserving genetically enhanced pig embryos

Researchers led by a University of Missouri-Columbia professor of reproductive biotechnology have reported success in freezing and preserving swine embryos that were created by in vitro techniques and that carried modified genetic material.

3 May 2006

Researchers identify novel agent that protects neurons involved in Parkinson's disease from being destroyed by rotenone

Researchers at the University at Buffalo affiliated with the New York State Center of Excellence in Bioinformatics and Life Sciences have identified a novel agent that can protect neurons involved in Parkinson's disease from being destroyed by the pesticide rotenone.

18 Apr 2006

Genetic switch that links animal growth and cancer

Laboratory discoveries by scientists at two universities may lead to new directions in cancer therapy drugs. The researchers have discovered that a genetic switch involved in growth and development of an animal is the same one used to prevent normal cells from becoming cancerous.

18 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

Sildenafil improves blood flow after heart attack in an animal model

Dogs treated with sildenafil, a drug most commonly used to treat erectile dysfunction, had better blood flow in coronary arteries than control animals, following an induced artery obstruction and treatment that modeled a heart attack and standard medical care given to people

13 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

Research explains why recipients of growth hormone therapy may develop colon polyps

The use of growth hormone therapy has been linked in some people to the development of colon polyps, a possible precursor to colorectal cancer - but medical researchers have debated the extent of a cancer risk.

11 Apr 2006

Antifibrotic effect of hepatocyte growth factor is impaired in lung fibroblasts isolated from African-Americans

Of the more than 40,000 persons who die each year in the U.S. from pulmonary fibrosis, the mortality rate among African-Americans is twice as high Caucasians.

11 Apr 2006

Protein loss linked to colon polyp risk from growth hormone

10 Apr 2006

Cancer virus protein p13 needed for successful infection and reproduction

New research shows that a protein made by a cancer-causing virus that was thought to be unimportant for its replication is in fact critically needed by the virus to initiate an infection and to reproduce.

4 Apr 2006

Researchers reverse juvenile diabetes in animal model

Groundbreaking human clinical trial for type 1 diabetes to start this spring in Pittsburgh - Children's Hospital of Pittsburgh of UPMC researchers reverse juvenile diabetes in animal model; Phase 1 clinical trial approved by FDA.

4 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006