Anti Epileptic Drug News and Research

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Targeted therapy prevents rare neurodevelopmental disorder seizures

Rapamycin treatment reduces seizure frequency and improves receptive language in patients with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, or Pretzel syndrome, a study finds.

29 Apr 2013

Sirolimus effective in treating children with Pretzel syndrome, new study reports

With a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully treated with a drug that modifies the disease process, minimizing seizures and improving receptive language.

25 Apr 2013

Maternal use of valproate during pregnancy increases risk of autism in offspring

Maternal use of valproate (a drug used for the treatment of epilepsy and other neuropsychological disorders) during pregnancy was associated with a significantly increased risk of autism in offspring, according to a study in the April 24 issue of JAMA.

24 Apr 2013

New review of medications to prevent migraines appears in Journal of General Internal Medicine

Migraine headaches are a major cause of ill health and a reduced quality of life. Some individuals suffer from a frequent and severe migraine problem which means that they require regular medication to try and prevent them.

18 Apr 2013

TBI can increase depression, personality impulsivity, PTSD in PNES patients

A new study by a Rhode Island Hospital researcher has found that traumatic brain injury (TBI) can significantly increase the odds of having major depression, personality impulsivity and post-traumatic stress disorder (PTSD) in patients with psychogenic nonepileptic seizures (PNES).

9 Apr 2013

Study reveals that EEG identifies high frequency of seizures in hospital patients

Electroencephalogram, which measures and records electrical activity in the brain, is a quick and efficient way of determining whether seizures are the cause of altered mental status and spells, according to a study by scientists at the University of California, San Francisco.

27 Mar 2013

DNA damage is part of regular brain activity, say scientists

Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process.

25 Mar 2013

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

The following research from Columbia University Medical Center and NewYork-Presbyterian Hospital is being presented at the 65th annual meeting of the American Academy of Neurology, March 16-23, 2013, in San Diego.

18 Mar 2013

Laboratory for Molecular Biodiscovery, KU Leuven partner for €9.5M 'PharmaSea' project

KU Leuven scientist Camila Esguerra and the Laboratory for Molecular Biodiscovery are coordinating a €9.5 million, EU-funded project to collect and study marine microbes extracted from some of the ocean's deepest, most extreme - and as-yet-unexplored -biomes.

12 Mar 2013

Opioids are main contributor to fatal overdoses

The number of deaths from drug overdoses in the United States in 2010 rose for the 11th consecutive year, show data from the National Center for Health Statistics.

25 Feb 2013

Valproate, pregnancy and IQ: an interview with Professor Kimford Meador

Valproate (sodium salt of valproic acid) is an anticonvulsant used in the treatment of epilepsy, migraine and bipolar disorder as well as some other off label psychiatric indications.

11 Feb 2013

No added benefit from perampanel in patients with epileptic fits

The drug perampanel has been approved since July 2012 as adjunctive therapy for adults and children aged 12 years and older with epileptic fits (seizures).

30 Jan 2013

Evidence links HPV16 to focal cortical dysplasia type IIB

Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) - the most common cause of cervical cancer - to a common form of childhood epilepsy.

28 Jan 2013

Lasting impact of fetal valproate exposure

Fetal exposure to the antiepileptic drug valproate has a dose-dependent negative impact on children’s IQ at age 6 years, shows a study in The Lancet Neurology.

25 Jan 2013

Taking antiepileptic drug valproate during pregnancy affects the IQ of children

Research published in The Lancet Neurology shows that taking the antiepileptic drug valproate during pregnancy affects the IQ of children up to the age of six.

23 Jan 2013

Management of hospital-onset seizures lacks standards

Seizures in patients admitted to hospital for nonseizure reasons – hospital-onset seizures – largely affect those without any history of seizures, often recur, and are linked to a high mortality, according to a study in JAMA Neurology.

21 Jan 2013

Pill color switch disrupts medication adherence

Simply changing the appearance of a prescription medication can significantly alter patients’ compliance with treatment, study findings show.

14 Jan 2013

Acorda Therapeutics acquires Neuronex

Acorda Therapeutics, Inc. today announced that the Company has completed the acquisition of Neuronex, Inc., a privately held company developing a nasal spray formulation of diazepam. Under the terms of the agreement, Acorda paid $6.8 million to Neuronex to complete the acquisition.

21 Dec 2012

Patients achieve favorable seizure outcomes after resective epilepsy surgery

Brain surgery for certain difficult forms of epilepsy often reduces or eliminates seizures for more than 15 years after the procedure, according to new research by neurologists at Henry Ford Hospital.

19 Dec 2012

Five young investigators receive prestigious grants at IOF’s 3rd Asia-Pacific Osteoporosis Meeting

Five young investigators from the Asia-Pacific region have been awarded prestigious grants on the closing day the IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting, a major medical conference organized by the International Osteoporosis Foundation (IOF) in Kuala Lumpur.

16 Dec 2012