Antibiotic News and Research

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Antibiotics are drugs used to treat infections caused by bacteria and other microorganisms.

Newly discovered gene mutation may account for many cases of immune deficiency

...in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic test for these conditions, which make people highly susceptible to infections and often go unrecognized because of a lack of good tests.

11 Jul 2005

Molecules that give certain bugs their color also help them resist attack by immune cells called neutrophils

A new study in the July 18 issue of The Journal of Experimental Medicine shows that gold-colored bacteria are more harmful than their unpigmented relatives.

11 Jul 2005

Evidence suggests that antibiotic use in agriculture has contributed to antibiotic resistance in the pathogenic bacteria of humans

Doctors have become increasingly concerned by the problem of "super-bugs" - bacteria that have become resistant to standard antibiotics.

6 Jul 2005

Tourette's and obsessive compulsive disorders linked to strep throat

A new study is suggesting that Strep throat infections can triple a child's risk of developing compulsive behaviors or tics, an indication that the same antibodies that attack the infection may also damage brain cells.

6 Jul 2005

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment.

6 Jul 2005

Researchers have identified a highly specific pathway that causes inflammation in lung tissue

...a discovery that could help in the design of more targeted treatments for patients with various lung diseases, including cystic fibrosis.

30 Jun 2005

Tetracycline antibiotic shows promise for treating osteoarthritis

A tetracycline antibiotic, doxycycline, has been successfully used to treat a wide-range of bacterial infections. In addition to its effects as an antibiotic, doxycycline has other actions as a drug and, in laboratory studies with animals and with human tissue, can inhibit the degradation of cartilage in a way that could be useful for the treatment of osteoarthritis (OA).

28 Jun 2005

If global efforts to prevent HIV/AIDS are to work long term, they must avoid suspicions of being unfair

Johns Hopkins infectious disease specialists who have spent more than two decades leading efforts to combat HIV and AIDS worldwide are warning that limited international relief supplies of antiretroviral therapies currently being distributed in Africa, Asia and the Caribbean will not get to those who can least afford to pay for them.

28 Jun 2005

Ethnicity makes little difference in the quality of outpatient care

A new study from the Stanford University School of Medicine has found that once U.S. patients visit a doctor for outpatient care, their race and ethnicity make little difference in the quality of care they receive.

28 Jun 2005

Greater use of evidence-based medicine needed in US outpatient care

Although the quality of outpatient care in the United States has improved over the last decade, greater use of evidence-based medicine is needed, however, and quality of care is not significantly associated with the patient's racial or ethnic background, according to a study in the June 27 issue of Archives of Internal Medicine.

27 Jun 2005

Light used to regulate protein synthesis

Proteins are the puzzle-pieces of life, involved in how organisms grow and flourish, but studying their complex biological processes in living systems has been extremely difficult.

27 Jun 2005

Technique called phylogenetic footprinting reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication - and they did it solely by computer keystrokes and mouse clicks.

27 Jun 2005

Tsunami leaves patients with unusual infections

According to a report in the New England Journal of Medicine, the December tsunami which left more than 200 000 people dead or missing in Asia and Africa, appears to have caused some unusual lung and sinus infections and also a paralysing brain infection.

27 Jun 2005

Antibiotics not effective for many coughs

In a study of more than 500 patients who were suffering from acute bronchitis or pharyngitis it was found that whether or not antibiotics were prescribed, the irritating bouts of coughing still continued for an average of almost 12 days after the visit to the doctor.

22 Jun 2005

Antibiotics show little benefit for uncomplicated lower respiratory tract infections

Patients with uncomplicated lower respiratory tract infections, such as bronchitis, who were given antibiotics had little difference in symptom relief compared to patients who did not receive antibiotics, according to a study in the June 22/29 issue of JAMA: The Journal of the American Medical Association.

21 Jun 2005

Most children with infective conjunctivitis (pinkeye) do not need treatment with an antibiotic

One in eight school children have an episode of conjunctivitis every year. This amounts to more than 1 million episodes in the UK and more than 5 million in the USA. Diagnosis of the condition is usually straight forward but doctors find difficulty in differentiating a viral cause from a bacterial cause.

21 Jun 2005

Australian community-based intervention program to successfully reduce antibiotics use for colds and flu

The South Australian Health Department is leading a community-based intervention program to successfully reduce antibiotics use for colds and flu.

21 Jun 2005

First new treatment for Elephantiasis (lymphatic filariasis)

Scientists at the Liverpool School of Tropical Medicine have proved that a single course of one antibiotic may hold the key to curing the parasitic worm disease Elephantiasis (lymphatic filariasis) that has been one of the most common causes of global disability since Biblical times.

21 Jun 2005

Scientists identify inhibitors of the anthrax toxin

A collaborative team of scientists led by The Burnham Institute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") that could be developed into an emergency treatment for exposure to inhalation anthrax.

21 Jun 2005

Expert says the world is not ready for the next pandemic

Michael T. Osterholm is Director of the Center for Infectious Disease Research and Policy, Associate Director of the Department of Homeland Security's National Center for Food Protection and Defense, and Professor at the University of Minnesota's School of Public Health.

21 Jun 2005