Anticoagulant News and Research

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Genetic analysis of opioid-induced hyperalgesia

In findings published in Nature Biotechnology (May 2006, vol. 24 No. 5), Roche scientists present a new method for analyzing the metabolism of a commonly prescribed drug.

10 May 2006

Blood clots in the brain linked to Alzheimer's and dementia

According to researchers, from the University of Manchester, UK, spontaneous blood clots are significantly associated with both Alzheimer's disease and vascular dementia.

From The University of Manchester 1 May 2006

First human implant of new style Australian artificial heart

On 22 March 2006, a 48 year old male patient suffering NYHA Class IV Heart Failure became the first recipient of HeartWare's HVAD mechanical circulatory assist device.

27 Mar 2006

Jefferson neurosurgeons use innovative "Wingspan Stent System" to open clogged brain arteries

Neurosurgeons at Thomas Jefferson University Hospital in Philadelphia are the first in the region and among the first in the nation to successfully use a new stent specifically designed to open potentially life-threatening clogged arteries in the brain, preventing a stroke.

22 Mar 2006

$Warfarin increases risk of bone fracture$

Warfarin increases risk of bone fracture

Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at Washington University School of Medicine in St. Louis.

23 Jan 2006

First-of-its-kind study in heart attack patients seeks to prevent heart failure with stem cells

University of Rochester Medical Center researchers have announced the launch of a study that will examine whether transplanted stem cells can be safely used to treat damaged heart muscle in patients just after their first heart attack.

23 Jan 2006

Pharmacogenetics can reduce health care costs

Chances are good that a medication you take is one of several drugs that can be affected by genetic factors, according to researchers at Washington University School of Medicine in St. Louis and the St. Louis College of Pharmacy.

5 Jan 2006

Fish oil supplements prevent declines in heart rate variability

A two-gram fish oil supplement given daily to elderly persons prevented a decline in heart rate variability caused by tiny, dangerous airborne pollutant particles. Heart rate variability, a measure of the autonomic nervous system's regulation of the heart, is an independent risk factor for cardiac arrhythmias, heart attack or sudden death.

15 Dec 2005

Leeches, useful tools in the treatment of cardiovascular diseases

The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases.

24 Oct 2005

Myriad Genetics nears completion of antithrombin drug trial

Myriad Genetics announced today that it is rapidly nearing completion of the preclinical data package on MPC-0920, its antithrombin drug candidate, for submission to the FDA prior to beginning human clinical trials.

11 Oct 2005

Women with atrial fibrillation face a higher risk of ischemic stroke than men

Women with atrial fibrillation who are not on anticoagulant therapy have a higher rate of ischemic stroke and face a higher absolute risk for stroke than do men with the condition, according to a joint study

19 Sep 2005

Part of largest randomised international trial program ever conducted in atrial fibrillation (AF) discontinued

Study treatments for the ACTIVE W trial of the ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) program have been discontinued due to a significant difference in efficacy, in favour of the standard oral anticoagulation (OAC) over antiplatelet therapy (clopidogrel plus aspirin).

6 Sep 2005

Catheter interventions help to prevent stroke

According to WHO statistics, stroke is the second most frequent cause of death worldwide. Cardiac causes account for up to 20% of strokes. Transcatheter occlusion of patent foramen ovale and left atrial appendage eliminate the most important sources for cardiac embolism.

6 Sep 2005

FDA Approves Aceon to reduce risk of cardiovascular mortality in patients with stable coronary artery disease

Solvay Pharmaceuticals and CV Therapeutics have announced that the U.S. Food and Drug Administration (FDA) has approved Aceon (perindopril erbumine) Tablets for the treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or non-fatal myocardial infarction (MI).

24 Aug 2005

Reasons for complications with kidney failure patients

Mayo Clinic researchers searching for explanations of high mortality rates among kidney failure patients undergoing hemodialysis are focusing their attention on the use of heparin, a drug used to reduce clotting of the blood.

18 Aug 2005

Latest findings on aspirin resistance

Treatment failures occur with any drug and aspirin is no exception. Evidence is growing that some people will not respond to the anti-coagulant action of aspirin and the drug will not protect against cardiovascular events despite its regular intake.

9 Aug 2005

Beta-blockers top choice for prevention and rate control for postoperative atrial fibrillation

The American College of Chest Physicians (ACCP) has released the first evidence-based clinical practice guidelines for the prevention and management of postoperative atrial fibrillation (AF) after cardiac surgery.

9 Aug 2005

Heparinase I is not a suitable replacement for protamine

The results of an international clinical trial led by Duke University Medical Center researchers has shown that a new drug is not a suitable replacement for protamine, a drug that has been used for more than 40 years after coronary artery bypass surgery to return thinned blood to its normal state.

1 Aug 2005

Thalidomide may be a potent anti-cancer treatment

When people hear "thalidomide," many think "birth defects," however, evidence has come to light that this once-banned drug can be used as a potent anti-cancer treatment.

20 Jun 2005

Genetic variation alters response to anti-clotting drug warfarin

Millions of people take the anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. But the proper dose of warfarin can vary greatly and can be hard to predict.

1 Jun 2005