Anticonvulsants News and Research

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New ray of hope for children with Batten disease

Investigators at the University of Rochester Medical Center have uncovered a promising drug therapy that offers a ray of hope for children with Batten disease

13 Dec 2007

Little evidence to support therapies for post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a severe and ongoing emotional reaction to an extreme psychological trauma; it affects significant numbers of people, in particular military personnel and veterans, who have seen active duty in war zones.

22 Oct 2007

Review of PTSD treatments

Many people, including significant proportions of active duty military personnel and veterans, suffer from post-traumatic stress disorder (PTSD), often in conjunction with other injuries or illnesses.

19 Oct 2007

FDA approves Norditropin for short stature in children with Noonan syndrome

Novo Nordisk has announced that Norditropin (somatropin[rDNA origin] injection) received U.S. Food and Drug Administration (FDA) approval for the treatment of short stature in children with Noonan syndrome.

3 Jun 2007

Cancer patients are at high risk for potential drug interactions

Potential drug interactions from prescribed medications are common among cancer patients and may cause unnecessary harm, according to a study in the April 18 Journal of the National Cancer Institute .

18 Apr 2007

FDA approves Prezista (darunavir)

FDA approves Prezista (darunavir), a new drug for adults whose infection with the human immunodeficiency virus (HIV) has not responded to treatment with other antiretroviral drugs.

26 Jun 2006

Novel research points to promising relief target for chronic pain

By some accounts, chronic pain affects nearly 100 million Americans from such varied causes as arthritis, sciatica, cancer, diabetes. Most forms of pain result from identifiable causes which serve the "good" purpose in warning of a real physical problem that needs attention, or rest.

6 Jun 2006

Off-label prescribing common, often not backed by data

A study of office-based physicians in the United States suggests that about one-fifth of medications are prescribed to treat conditions for which they are not approved by the U.S. Food and Drug Administration (FDA), and that nearly three-fourths of those uses lack strong scientific support, according to an article in the May 8 issue of Archives of Internal Medicine.

9 May 2006

Large scale study shows success of epilepsy surgery

In one of the largest epilepsy surgery studies ever conducted, Mayo Clinic researchers have found that 81 percent of patients with intractable epilepsy become totally or nearly seizure-free six months following epilepsy surgery. Ten years later, 72 percent remained totally or nearly seizure-free.

11 Apr 2006

Repligen commences phase 2 trial of RG2417 for bipolar depression

Repligen Corporation today announced that the Company has initiated a Phase 2 clinical trial of RG2417, an oral formulation of uridine, in patients with bipolar depression.

9 Mar 2006

SSRIs most effective in treating post-traumatic stress disorder

A variety of medications can help reduce the core symptoms of post-traumatic stress disorder (PTSD) as well as reduce associated depression and disability, but selective serotonin reuptake inhibitors (SSRIs) should be considered as first line agents as there is most evidence showing that these can be effective.

25 Jan 2006

FDA panel approves vaccine for shingles

According to an FDA advisory panel, studies show that an experimental vaccine to prevent shingles can cut the rate of infection by about half in people 60 and older and help curb related pain.

19 Dec 2005

Bumetanide may help treat seizures in newborns

A diuretic drug called bumetanide may serendipitously help treat seizures in newborns, which are difficult to control with existing anticonvulsants, according to a study in the November Nature Medicine.

1 Nov 2005

Effects of anticonvulsants on women

The Epilepsy Foundation has issued a Call to Action to women of childbearing age who take anticonvulsant medications for conditions that include epilepsy, migraine headaches, and certain psychiatric disorders, urging them to talk to their healthcare providers about treatment options.

4 Oct 2005

Depressant benzodiazepine especially effective at treating seizure in alcohol withdrawal syndrome patients

Tranquilizers work better than placebos at treating the symptoms of alcohol withdrawal syndrome but they may not work better than other drugs, according to a new review of recent studies.

29 Aug 2005

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take."

19 Jul 2005

Anticonvulsant drug valproate poses greater birth-defect risk than suspected

Use of the anticonvulsant drug valproate during pregnancy may pose a significantly great risk of birth defects than does use of other antiseizure medications.

22 Mar 2005

Anti-seizure drugs slow aging in roundworms

Researchers at Washington University School of Medicine in St. Louis have discovered that a class of anti-seizure medications slows the rate of aging in roundworms. The worms, when exposed to drugs used to treat epilepsy in humans, lived longer and retained youthful functions longer than normal.

17 Jan 2005

Long-term use of opioid prescriptions by veterans

Veteran patients who receive long-term opioid prescriptions generally are treated with modest and stable medication dosages, according to an article in the November 22 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals.

23 Nov 2004