Apolipoprotein News and Research

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Myelin breakdown appears to be key contributor to Alzheimer disease later in life

A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease.

8 Jan 2006

Breakdown of myelin linked to genetic risk of Alzheimer's disease

2 Jan 2006

Decaffeinated coffee may cause an increase in harmful LDL cholesterol

Decaffeinated -- not caffeinated -- coffee may cause an increase in harmful LDL cholesterol by increasing a specific type of blood fat linked to the metabolic syndrome, hints a new study presented at the American Heart Association's Scientific Sessions 2005.

16 Nov 2005

HDLs provide human immunity to certain parasites

For years biomedical researchers have known that high density lipoproteins, commonly called HDLs or "good cholesterol," are responsible for protecting humans from certain parasites, but couldn't explain how.

30 Oct 2005

Women with defects in lipoprotein metabolism may actually be able to bear children without complications

A group of Belgian researchers has determined that a pregnant woman's ability to metabolize fats is determined not only by her genes but by her baby's genes as well.

30 Oct 2005

No increase in anxiety or depression when children of people with Alzheimer's get genetic testing

Adult children of people with Alzheimer’s disease were satisfied and unharmed by the experience of genetic risk assessment, even when results suggested they might be at risk, according to a new study presented at the first Alzheimer’s Association’s International Conference on the Prevention of Dementia.

21 Jun 2005

Two common gene variations are associated with the risk for developing chronic kidney disease

Two common gene variations are associated with the risk for developing chronic kidney disease, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions. One variant increases risk and the other decreases risk with a similar effect in whites, African-Americans, diabetic and non-diabetic individuals.

14 Jun 2005

Muraglitazar lowers blood glucose and helps dyslipidemia seen in diabetes

A novel compound provides long-term lowering of blood glucose levels and improves plasma lipids (fats) that are often a problem in people with type 2 diabetes -- all in a once-daily pill, according to a report presented today at the American Diabetes Association's 65th Annual Scientific Sessions.

12 Jun 2005

Researchers identify marker of heart disease in low-birthweight babies

Some low birth weight infants have large particles rich in apolipoprotein C-1, a blood protein that could put them at risk for heart disease later in life, according to a national study led by Johns Hopkins Children's Center researchers.

19 Apr 2005

Marker of heart disease in low-birthweight babies identified

19 Apr 2005

Neurologists may have foot in the door to preventing Alzheimer’s before it starts

A study led by Mayo Clinic shows for the first time that a drug appears to have a slowing effect -- though limited -- on the progression from mild cognitive impairment to Alzheimer's disease. The findings will be published online in the New England Journal of Medicine on April 14.

13 Apr 2005

Clinical diagnosis of Alzheimer's may be delayed

In a study of people with mild cognitive impairment (MCI), those who took the drug donepezil were at reduced risk of progressing to a diagnosis of Alzheimer's disease (AD) during the first year of the trial, but by the end of the 3-year study there was no benefit from the drug. Vitamin E was also tested in the study and was found to have no effect at any time point in the study when compared with placebo.

13 Apr 2005

Brain imaging shows differences in people at risk for Alzheimer's

Using brain imaging, researchers at Columbia University Medical Center (CUMC) have found clear differences in brain function between healthy people who carry a genetic risk factor for Alzheimer's disease and those who lack the factor.

20 Nov 2004

Atorvastatin slows down mental decline and improves depressive symptoms in people with Alzheimer’s disease

The cholesterol-lowering drug atorvastatin slowed down mental decline and improved depressive symptoms in people with Alzheimer’s disease, according to a small pilot study reported at the American Heart Association’s Scientific Sessions 2004.

11 Nov 2004

Researchers help define Apolipoprotein E's role in the formation of amyloid brain lesions and the memory loss associated with Alzheimer's disease

A research team led by University of South Florida neuroscientist Huntington Potter, PhD, CEO of the Johnnie B. Byrd Sr. Alzheimer's Center & Research Institute, for the first time has defined how the protein Apolipoprotein E (ApoE) contributes to both the formation of amyloid brain lesions and the memory loss associated with Alzheimer's disease.

1 Nov 2004

Ezetrol co-administration with statin therapy lowers LDL cholesterol in diabetics

Results from two new clinical trials show that patients with diabetes and metabolic syndrome who are treated with ezetimibe (EZETROL®) co-administered with a statin experience greater reductions in LDL (“bad”) cholesterol, compared to patients taking a statin alone.

7 Sep 2004

Apolipoprotein News and Research

Myelin breakdown appears to be key contributor to Alzheimer disease later in life

Breakdown of myelin linked to genetic risk of Alzheimer's disease

Decaffeinated coffee may cause an increase in harmful LDL cholesterol

HDLs provide human immunity to certain parasites

Women with defects in lipoprotein metabolism may actually be able to bear children without complications

No increase in anxiety or depression when children of people with Alzheimer's get genetic testing

Two common gene variations are associated with the risk for developing chronic kidney disease

Muraglitazar lowers blood glucose and helps dyslipidemia seen in diabetes

Researchers identify marker of heart disease in low-birthweight babies

Marker of heart disease in low-birthweight babies identified

Neurologists may have foot in the door to preventing Alzheimer’s before it starts

Clinical diagnosis of Alzheimer's may be delayed

Brain imaging shows differences in people at risk for Alzheimer's

Atorvastatin slows down mental decline and improves depressive symptoms in people with Alzheimer’s disease

Researchers help define Apolipoprotein E's role in the formation of amyloid brain lesions and the memory loss associated with Alzheimer's disease

Ezetrol co-administration with statin therapy lowers LDL cholesterol in diabetics

Drinking alcohol regularly in your 40's increases risk of mild cognitive impairment

Vast majority of heart attacks may be predicted by nine easily measurable factors

Not all good cholesterol helps to protect arteries from becoming clogged with fatty deposits

New blood test to detect ovarian cancer

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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