Apolipoprotein News and Research

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Liver receptor mutations linked to liver dysfunction, cholesterol accumulation, and hepatitis

Damaging LXRα variants are linked to liver cholesterol buildup and hepatitis, emphasizing the receptor's importance in cholesterol sensing and liver function.

27 Sep 2024

Study uncovers hidden proteins fueling heart disease and stroke

Researchers identified key proteins linked to cardiovascular disease, highlighting new targets for drug development using genetic and observational analyses in UK and China biobanks.

26 Sep 2024

Increasing daily consumption of flavonoid-rich foods may lower dementia risk

Research shows that flavonoid-rich diets, including tea and red wine, are associated with a lower risk of dementia in genetically susceptible individuals.

25 Sep 2024

Lipid metabolism plays a critical role in red blood cell recovery from acute anemia

Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, leading to the proliferation of immature cells (erythroblasts) that eventually become red blood cells, thus restoring the red blood cell count.

20 Sep 2024

Study helps explain why having ApoE4 increases risk of neurodegeneration

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

18 Sep 2024

Early cholesterol spikes fuel atherosclerosis by altering macrophages

Early intermittent hyperlipidemia significantly accelerates atherosclerosis by disrupting macrophage function, highlighting the need for early cholesterol management.

6 Sep 2024

European Society of Cardiology highlights underrecognized link between obesity and heart disease

Obesity is a key factor in cardiovascular disease, prompting the ESC to recommend comprehensive strategies for prevention and management to reduce health risks.

3 Sep 2024

American football head impacts tied to increased brain damage and cognitive decline

Repetitive head impacts in former American football players are linked to increased perivascular space volume, which correlates with cognitive decline and neurodegeneration. The study suggests that the force of head impacts may be more critical than frequency, with potential protective effects from β-blocker use.

1 Sep 2024

Routine lipoprotein(a) testing recommended for all adults

Heart experts say that everyone should have their levels of lipoprotein (a) (Lp(a) measured routinely at least once in life, following research from one of the most populous EU countries, Poland, that shows how common high levels of Lp(a) are in the general population.

29 Aug 2024

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

Study reveals genetic link between Alzheimer's disease, lipid metabolism, and coronary artery disease

The genetic overlap between Alzheimer's disease (AD) (a neurodegenerative disorder causing memory loss and cognitive decline), lipid profiles, and coronary artery disease (CAD).

20 Aug 2024

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

The long-term subjective cognitive decline risk associated with Herpes zoster infections.

19 Aug 2024

Anti-inflammatory diets could lower dementia risk among older individuals with cardiometabolic disorders

Researchers investigated whether anti-inflammatory diets support cognitive functions among cardiometabolic disease (CMD) patients.

15 Aug 2024

Coronary atherosclerosis prevalent even in low-risk adults with normal cholesterol levels

Researchers found that coronary atherosclerosis is prevalent in asymptomatic, middle-aged US adults without traditional ASCVD risk factors, and increases with higher levels of LDL-C, non-HDL-C, and apoB.

8 Aug 2024

Amyloid immunotherapy for early Alzheimer's: Promising but fraught with challenges

Researchers highlighted the complexities of using amyloid immunotherapy for early Alzheimer's disease, discussing its clinical benefits, challenges, and broader health implications. Despite some positive results, concerns over adverse effects, trial biases, and cost hinder widespread adoption.

7 Aug 2024

Apolipoprotein News and Research

Liver receptor mutations linked to liver dysfunction, cholesterol accumulation, and hepatitis

Study uncovers hidden proteins fueling heart disease and stroke

Increasing daily consumption of flavonoid-rich foods may lower dementia risk

Lipid metabolism plays a critical role in red blood cell recovery from acute anemia

Study helps explain why having ApoE4 increases risk of neurodegeneration

Early cholesterol spikes fuel atherosclerosis by altering macrophages

European Society of Cardiology highlights underrecognized link between obesity and heart disease

American football head impacts tied to increased brain damage and cognitive decline

Routine lipoprotein(a) testing recommended for all adults

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

Study reveals genetic link between Alzheimer's disease, lipid metabolism, and coronary artery disease

APOE ε4 carrier status increases the long-term cognitive decline risk associated with herpes zoster

Anti-inflammatory diets could lower dementia risk among older individuals with cardiometabolic disorders

Coronary atherosclerosis prevalent even in low-risk adults with normal cholesterol levels

Amyloid immunotherapy for early Alzheimer's: Promising but fraught with challenges

Ketogenic vs. low-sugar diet: Study reveals distinct metabolic effects and fat loss benefits

Omega-3 fatty acids show potential in protecting brain health in older adults

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

New research reveals keto diet’s impact on cholesterol and gut microbiome

Shorter exclusive breastfeeding periods for women with a higher BMI compared to those with lower obesity classifications

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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