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Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Three experimental blood tests used to identify people in early stages of Alzheimer's disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis.

21 Apr 2022

Researchers discover over 40 new genetic markers for Alzheimer’s disease

A new Nature Genetics study describes over 70 gene markers that appear to be significantly associated with AD risk using translational genomics.

6 Apr 2022

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or "bad" cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of heart disease risk.

3 Apr 2022

Investigational drug vupanorsen reduces non-HDL cholesterol by up to 28%

The investigational drug vupanorsen reduced total levels of non-high-density lipoprotein (non-HDL) cholesterol by up to 28% in patients with high cholesterol who were already taking a cholesterol-lowering statin medication, in a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Community-based approach to genetic testing may have beneficial effects, study finds

In 2010, scientists discovered that African Americans who are born with certain variants of a gene called apolipoprotein L1 (APOL1) have a higher-than-average risk for experiencing chronic kidney disease (CKD).

4 Mar 2022

Research sheds light on the role of lipids in Alzheimer’s disease development

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE.

1 Mar 2022

Gene variants associated with acute kidney injury in Black veterans hospitalized with COVID-19

Gene variants increased the risk of acute kidney injury and death in veterans of African ancestry who were hospitalized with COVID-19, according to a new study published in JAMA Internal Medicine.

10 Feb 2022

Blood proteins could be potential targets for future drugs to slow aging process

Two blood proteins have been shown by scientists to influence how long and healthy a life we live, research suggests.

24 Jan 2022

Study: Nearly 30% of people with blinding retinal disease can safely stop eye injection therapy

In a preliminary study of 106 people with "wet" age-related macular degeneration, Johns Hopkins Medicine researchers report that as many as a third of those with the blinding retinal disease may someday be able to safely stop eye injection therapy without further vision loss.

18 Jan 2022

Improving air quality may reduce dementia risk in older women

Improving air quality appears to slow cognitive decline and reduce the risk of developing dementia in older women living in the U.S., according to a new study by researchers from the Keck School of Medicine of USC.

10 Jan 2022

Alzheimer’s disease risk genes disturb the brain protective mechanism

The brain has a natural protective mechanism against Alzheimer's disease, and researchers at Baylor College of Medicine, Texas Children's Hospital and collaborating institutions have discovered that gene variants associated with risk of developing the disease disturb the protective mechanism in ways that can lead to neurodegeneration.

3 Jan 2022

SARS-CoV-2 infection leads to distinct changes in proteomic and peptidomic profiles and posttranslational modifications

A new study indicates that as a result of SARS-CoV-2 infection comprehensive changes in protein processing and regulation occur.

20 Dec 2021

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.

9 Dec 2021

Study reveals new way for detecting early risk of cardiovascular disease

The risk of developing cardiovascular disease is strongly associated with the "bad" LDL cholesterol. A large study by scientists at Karolinska Institutet now shows that two proteins that transport cholesterol particles in the blood provide early and reliable risk information.

1 Dec 2021

Apolipoprotein News and Research

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Investigational drug vupanorsen reduces non-HDL cholesterol by up to 28%

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Community-based approach to genetic testing may have beneficial effects, study finds

Research sheds light on the role of lipids in Alzheimer’s disease development

Gene variants associated with acute kidney injury in Black veterans hospitalized with COVID-19

Blood proteins could be potential targets for future drugs to slow aging process

Study: Nearly 30% of people with blinding retinal disease can safely stop eye injection therapy

Improving air quality may reduce dementia risk in older women

Alzheimer’s disease risk genes disturb the brain protective mechanism

SARS-CoV-2 infection leads to distinct changes in proteomic and peptidomic profiles and posttranslational modifications

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Study reveals new way for detecting early risk of cardiovascular disease

Fast evolution of SARS-CoV-2 driven by extensive RNA deamination by host cells

UT Southwestern study suggests potential way to prevent Alzheimer’s disease

Common oral diuretic pill may be a potential candidate for Alzheimer's treatment

Genetics can influence a person's response to Alzheimer's disease pathology, research suggests

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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