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Researchers culture human blood-brain barrier on a chip

A scrupulous gatekeeper stands between the brain and its circulatory system to let in the good and keep out the bad, but this porter, called the blood-brain barrier, also blocks trial drugs to treat diseases like Alzheimer's or cancer from getting into the brain.

10 Feb 2020

'Junk' DNA mutations highly significant in autism and stroke

Non-coding DNA, junk DNA, genetic dark matter – these are all names for the 98% of DNA that doesn’t directly code for proteins but is crucial in regulating protein synthesis. This is now the focus of a large new study published in the journal Nature Genetics.

25 Jul 2019

FDA approves first drug for treatment of neuromyelitis optica spectrum disorder

The U.S. Food and Drug Administration today approved Soliris (eculizumab) injection for intravenous use for the treatment of neuromyelitis optica spectrum disorder in adult patients who are anti-aquaporin-4 antibody positive.

27 Jun 2019

Healthy blood vessels could help stave off cognitive decline

High blood pressure may affect conditions such as Alzheimer’s disease by interfering with the brain’s waste management system, according to new research in rats published in JNeurosci. Maintaining blood vessel health could therefore help stave off cognitive decline.

From Society for Neuroscience 19 Jun 2019

New fluorescent sensor can detect migrating cancer cells

A new fluorescent sensor developed by researchers from the University of Adelaide can detect migrating cancer cells and could be used to target medication to stop metastasis in aggressive cancers.

22 May 2019

Drug reduces risk of relapse with neuromyelitis optica spectrum disorder, study shows

The drug eculizumab, a synthetic antibody that inhibits the inflammatory response, significantly reduced the risk of relapse with neuromyelitis optica spectrum disorder.

3 May 2019

Lipid that helps keep skin cell turnover on track may aid in psoriasis

A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.

28 Nov 2018

Alexion announces positive results from Phase 3 PREVENT study of Soliris in patients with NMOSD

Alexion Pharmaceuticals, Inc. today announced positive topline results from the Phase 3 PREVENT study of Soliris in patients with anti-aquaporin-4 auto antibody-positive neuromyelitis optica spectrum disorder.

24 Sep 2018

Malaria-causing parasite seeks refuge inside the liver to replicate and survive

When the malaria-causing Plasmodium parasite first slips into the human bloodstream, injected by the bite of an infected mosquito, it does not immediately target red blood cells.

23 May 2018

Mayo Clinic launches new clinical test that distinguishes IDDs from multiple sclerosis

Mayo Clinic has launched a first-in-the-U.S. clinical test that will help patients who recently have been diagnosed with an inflammatory demyelinating disease (IDD) but may be unsure of the exact disorder.

28 Nov 2017

Cancer treatment may be effective therapy for psoriasis

HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.

31 May 2017

Research shines new light on role of AKI in development of lung injury

Acute kidney injury (AKI) is sudden kidney failure or damage lasting from a few hours to several days. During this time, the kidney's ability to maintain a proper balance of bodily fluids is compromised and causes a buildup of waste products in the blood.

22 Feb 2017

Caltech scientists develop simple way to visualize gene expression with MRI

Genes tell cells what to do -- for example, when to repair DNA mistakes or when to die--and can be turned on or off like a light switch.

23 Dec 2016

OHSU scientists identify potential target for preventing and treating Alzheimer's disease

A new scientific discovery may provide a future avenue for treatment and prevention of Alzheimer's disease.

1 Dec 2016

Scientists identify potential drug for pre-treating cells that swell after mild traumatic brain injury

A team of biomedical engineering researchers at the University of Arkansas have identified a cause of fluid swelling of the brain, or cellular edema, that occurs during a concussion.

22 Nov 2016

International consensus panel reviews new diagnostic criteria for neuromyelitis optica spectrum disorder

New diagnostic criteria were introduced this week for neuromyelitis optica, now called neuromyelitis optica spectrum disorder, which is an inflammatory disease of the central nervous system that is sometimes mistaken for multiple sclerosis.

9 Jul 2015

Water retention linked to changes in sex hormone levels

Water retention—a cause of bloating—is associated with changes in sex hormone levels. Many women experience water retention during menopause, but how sex hormones affect water balance is not understood. A new study in in the American Journal of Physiology—Renal Physiology sheds light on the connection, finding that sex hormones can directly control how the body reabsorbs water.

22 Jun 2015

Researchers develop noninvasive method to detect kidney cancer early

If kidney cancer is diagnosed early — before it spreads — 80 percent of patients survive. However, finding it early has been among the disease's greatest challenges.

20 Mar 2015

Two Protein Science authors selected as winners of 2015 Best Paper Awards

The Protein Society, an international, trans-disciplinary community of scientists dedicated to protein research, announces the third annual selection of two Protein Science authors as winners of the 2015 Best Paper Awards.

14 Jan 2015

Study provides platform for detailed study of nerve injury and repair during Wallerian degeneration

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation.

31 Jul 2014