Arachidonic acid is an omega-6 fatty acid that is present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositides) of membranes of the body's cells, and is abundant in the brain. It is the counterpart to the saturated arachidic acid found in peanut oil.
Researchers at Nagoya University in Japan have identified two enzymes that are involved in macrophage polarization, one of the key factors affecting fibrosis.
As the number of children born with a vision-impairing condition known as optic nerve hypoplasia (ONH) increases, scientists with the Fralin Biomedical Research Institute at VTC are investigating potential ways to prevent and treat the disease.
Omega-3 and -6 fatty acids ingested through the diet are metabolized into bioactive compounds that influence inflammation. In a recent the journal Biomedicines study, scientists reviewed the existing literature and summarized their findings related to the role of omega-3 and omega-6 metabolites during pregnancy.
Genetic background has an effect on the metabolism of the essential polyunsaturated fatty acids alpha-linolenic acid and linoleic acid, a recent study from the University of Eastern Finland shows.
Bronchial constriction is what makes many lung diseases like asthma so dangerous. Researchers have discovered a new signaling pathway that causes the airways to widen.
A new study demonstrated that prostaglandin E2 (PGE2) stimulates hair follicle growth.
Two separate findings by a University of Houston nationally recognized expert in systemic lupus erythematosus (SLE or lupus), a chronic autoimmune disease that affects multiple organs including the kidneys, skin, joints and heart, are being reported in scientific and medical journals.
Researchers examine potential correlations between NSAID use and COVID-19 severity.
Researchers conducted a systematic review to assess the impact of polyunsaturated fatty acid levels on COVID-19-related hospitalization and mortality.
Researchers at the University of Michigan Rogel Cancer Center found that a cytokine, a category of protein that acts as messengers in the body, and a fatty acid can work together to trigger a type of cell death previously defined by studies with synthetic molecules.
A new study discusses the possible role of melatonin, an antioxidant and anti-inflammatory agent, in treating COVID-19.
A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.
In a new study, researchers compared the serum levels of bioactive lipids in a cohort of 50 in-patients who had confirmed symptomatic SARS-CoV-2 infection with that of a control group.
A new study using genetically engineered mice and human cell and tissue samples has added to evidence that higher levels of inflammatory chemicals involved in fat metabolism occur in people with amyotrophic lateral sclerosis (ALS), the neuromuscular disorder, also known as Lou Gehrig's disease.
Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.
A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).
A potentially valuable new study discusses the role of lipids in the hyper-inflammatory phenomena that take place within the lungs of patients with severe or critical COVID-19. Involving a large variety of specialized lipids with biological activity, this process includes the generation and release of pro and anti-inflammatory lipids.
Like people, cells in the human body protect their personal space. They seem to know how much space they need, and if it gets too tight, most cells prefer to break free.
Type 1 diabetes, or T1D, is an autoimmune disease in which the body's immune cells -; led by inflammatory macrophages -; attack and destroy the beta cells of the pancreas that produce insulin.
Now, a new study published on the preprint server bioRxiv in June 2020 reports the discovery of a novel free fatty acid (FFA) binding pocket on the SARS-CoV-2 virus that could explain in part the viral effects of hyperinflammation, immune modulation, and membrane structure.