Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the plant Artemisia annua. Not all plants of this species contain artemisinin.
News-Medical spoke to researchers from the University of Warwick about their research investigating natural antimicrobials and their potential as antibiotics.
Resistance to artemisinin, the main component of the current antimalarial treatments recommended by WHO, is already widespread in South-East Asia, but it had not previously been described in Africa.
Southwest Research Institute and The Uni-versity of Texas at San Antonio are working to synthesize novel highly potent derivatives of the antimalarial drug artemisinin with the goal of creating a powerful, cost-effective malaria treatment.
The first study to elucidate the dynamics of membrane cholesterol transport in erythrocytes has been successfully concluded using holotomography microscopy.
A paper recently published in Nature Communications is the first to show a connection between demand from certain developed countries for agricultural commodities and the growing risk of malaria in the countries that supply those goods.
The U.S. Army Medical Research and Development Command announced today that the U.S. Food and Drug Administration granted marketing approval for Artesunate for Injection, an initial treatment for severe malaria.
A fast-acting anti-malarial compound discovered at St. Jude Children's Research Hospital was well tolerated and showed promising anti-malarial effects in the first study in humans.
A new study describing the outcome of a clinical trial of two malaria treatment protocols involving the use of triple therapies based on artemisinin reports their high efficacy and low adverse effects.
New technology employing single cell genome sequencing of the parasite that causes malaria has yielded some surprising results and helps pave the way for possible new intervention strategies for this deadly infectious disease, according to Texas Biomedical Research Institute Assistant Professor Ian Cheeseman, Ph.D. Dr. Cheeseman was Principal Investigator of a three-year study published in the January 2020 edition of Cell Host & Microbe, a high-impact peer-reviewed publication.
Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes.
The scientists research a building block of organic molecules needed for medical chemistry development. Spirocycles in nature is an element, that chemists are crazy about. This element presents in artemisinin, the most effective group of drugs against malaria.
Researchers have found that some soups have antimalarial properties and can interrupt the life cycle of a malarial parasite.
Researchers from Israel, in collaboration with others looked at the effects of the malaria plasmodium on red blood cells in vivo in presence of a drug, to understand the workings of the pathogen in its disease causing ability and also lay foundation for development of effective treatment for the deadly disease.
Malaria, which ravages hot tropical areas, could be treated effectively using a protein extracted from an Antarctic sponge.
In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum parasites that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs.
Researchers have found that severe malnutrition is associated with lower exposure to the antimalarial drug lumefantrine in children treated with artemether-lumefantrine, the most common treatment, for uncomplicated falciparum malaria.
One of the keys to quickly diagnosing anti-malarial drug resistance -- potentially saving lives -- lies in testing whole blood instead of extracting DNA, eliminating processing steps that can take hours or days.
Antimalarial drugs appear to follow a typical pattern, with early effectiveness eventually limited by the emergence of drug resistance.
Researchers have found that anti-malarial drug artemisinin could help patients with genetic or hereditary hearing loss. The study results were published in the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS). The study was titled, “Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model.”
If a genetically or synthetically engineered organism is released into the environment, how will we know?