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Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

The class of immunotherapies known as checkpoint inhibitors have proven to be a highly effective and advantageous treatment option for many cancer patients, but they don't work well for everyone, and oncologists have no reliable way to determine in advance which patients are likely to respond to these drugs.

7 Jun 2017

Obese people twice as likely to develop influenza despite getting flu shots

Although influenza vaccines are currently the best forms of protection to safeguard people against getting the flu, they are not effective in all cases.

6 Jun 2017

Reliable clinical assay detects Zika virus from semen samples

Research presented at ASM Microbe 2017 by experts at the Fertility and Cryogenics Lab shows a reliable clinical assay that can detect the Zika virus from semen samples.

5 Jun 2017

New genomic sequencing approach could be first step toward blood tests for early cancer detection

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high-intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

5 Jun 2017

Genetic sequencing could help direct treatment for 72% of advanced cancer patients

A new analysis finds that nearly three-quarters of 500 patients with advanced cancer could be referred to a potential targeted treatment based on the results of a comprehensive analysis of their tumor's genetic landscape.

2 Jun 2017

UCSB biologists develop new antimicrobial susceptibility test to transform the way antibiotics are tested

When a patient is prescribed the wrong antibiotic to treat a bacterial infection, it's not necessarily the physician who is at fault. The current antibiotic assay -- standardized in 1961 by the World Health Organization and used worldwide -- is potentially flawed.

2 Jun 2017

Researchers gain new insights into factors crucial for STIM1 activation

Triggered by decreases in ER Ca2+ level, conformational changes of the endoplasmic reticulum (ER) luminal domain in STIM1 would switch on its cytoplasmic domain (CT) to engage and gate ORAI channels on plasma membrane, resulting in Ca2+ influx.

1 Jun 2017

Study shows how high-sensitivity assay improves evaluation for chest pain patients

For some time now, patients in Sweden's emergency clinics complaining of chest pain have been evaluated using the "high-sensitivity troponin T" assay. In a large-scale registry study published in the Journal of the American College of Cardiology scientists at Karolinska Institutet show how this more sensitive analytical method has improved evaluation for these patients.

30 May 2017

Scientists create a faster, less labor-intensive test to detect “hidden” HIV

The search to develop a HIV cure has long been overwhelmed by a seemingly simple question: How do physicians find out if somebody is cured? The virus has an ability to lie dormant in immune cells at levels that could not be detected to all, however, the most expensive and time-consuming tests can find the hidden virus.

30 May 2017

Grifols provides Procleix Zika Virus Assay to screen blood donations in countries that accept products with CE marking

Grifols, one of the world’s leading producers of plasma-derived medicines, now provides European countries accepting products with the CE marking with a test to detect the presence of the Zika virus in donated blood. CE marking means a product conforms to relevant legislation for sale in the European economic area.

29 May 2017

TSRI scientists discover potential new therapy to stop deadly botulinum neurotoxin

Botulinum neurotoxin is probably best known to Americans as BOTOX, a cosmetic medicine, rather than as a cause of potentially dangerous foodborne illnesses.

26 May 2017

OGT makes several advances in hybridization-based targeted sequencing

Oxford Gene Technology, The Molecular Genetics Company, has made several advances in hybridisation-based target enrichment protocols that now enable researchers to prepare samples for sequencing in just one day.

26 May 2017

Multi-protein biomarker blood test to detect breast cancer can potentially reduce use of biopsy

A new study published in Clinical Breast Cancer demonstrates that Videssa® Breast, a multi-protein biomarker blood test to detect breast cancer, can help inform better decision-making after abnormal mammogram or other breast imaging results and potentially reduce use of biopsy by up to 67 percent.

24 May 2017

Dry blood samples could save resources, benefit early diagnostics and treatment

A drop of blood on filter paper, allowed to dry and stored for future diagnostic purposes - considerably easier than the present-day, resource-consuming method using frozen blood samples in plastic tubes.

22 May 2017

Sperm epigenetics and fertility

Epigenetics is a system of information that lies atop DNA to control which genes are accessible, active and inactive. Each cell in your body essentially has identical DNA, but they have different patterns of expression.

18 May 2017

New IsoPSA assay detects prostate cancer more precisely than current tests

A team of researchers from Cleveland Clinic, Louis Stokes Cleveland VA Medical Center, Kaiser Permanente Northwest, and other clinical sites have demonstrated that a new blood test known as IsoPSA detects prostate cancer more precisely than current tests in two crucial measures - distinguishing cancer from benign conditions, and identifying patients with high-risk disease.

15 May 2017

Researchers develop new test that predicts need for massive blood transfusion in trauma patients

By combining a conventional laboratory measurement of blood clotting time (known as the International Normalized Ratio or INR) with a new test of blood clot strength, based upon thrombelastography (TEG), researchers at the University of Colorado's Department of Surgery, Denver, are able to quickly and efficiently assess the overall ability of blood to clot and identify trauma patients who were most in need of a massive blood transfusion.

15 May 2017

Guardant Health introduces new initiative to sequence tumor DNA of one million cancer patients

Guardant Health, the world leader in comprehensive liquid biopsies, announced an ambitious goal to sequence the tumor DNA of more than 1 million cancer patients within five years.

15 May 2017

Analyzing single-cell RNA data in pre-malignant tumors

RNA sequencing is basically the isolation of RNA from cells and the use of reverse transcriptase to turn the RNA into DNA. You can then use your standard DNA sequencing technologies to quantify the cDNA that you obtained from the reverse transcription reaction.

12 May 2017

Chromatrap introduces new FFPE ChIP-seq assay kit for tissue samples, biopsies, and difficult to lyse samples

Chromatrap has introduced a new and improved version of it’s popular solid phase chromatin immunoprecipitation assay kit for chromatin extracted from Formalin Fixed Paraffin Embedded tissue.

From Chromatrap® - Porvair Sciences Ltd 4 May 2017

Assay News and Research

Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

Obese people twice as likely to develop influenza despite getting flu shots

Reliable clinical assay detects Zika virus from semen samples

New genomic sequencing approach could be first step toward blood tests for early cancer detection

Genetic sequencing could help direct treatment for 72% of advanced cancer patients

UCSB biologists develop new antimicrobial susceptibility test to transform the way antibiotics are tested

Researchers gain new insights into factors crucial for STIM1 activation

Study shows how high-sensitivity assay improves evaluation for chest pain patients

Scientists create a faster, less labor-intensive test to detect “hidden” HIV

Grifols provides Procleix Zika Virus Assay to screen blood donations in countries that accept products with CE marking

TSRI scientists discover potential new therapy to stop deadly botulinum neurotoxin

OGT makes several advances in hybridization-based targeted sequencing

Multi-protein biomarker blood test to detect breast cancer can potentially reduce use of biopsy

Dry blood samples could save resources, benefit early diagnostics and treatment

Sperm epigenetics and fertility

New IsoPSA assay detects prostate cancer more precisely than current tests

Researchers develop new test that predicts need for massive blood transfusion in trauma patients

Guardant Health introduces new initiative to sequence tumor DNA of one million cancer patients

Analyzing single-cell RNA data in pre-malignant tumors

Chromatrap introduces new FFPE ChIP-seq assay kit for tissue samples, biopsies, and difficult to lyse samples

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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