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Study provides new insight into generation of new neurons in adulthood

Researchers at Sahlgrenska Academy at the University of Gothenburg, Sweden, in collaboration with research groups in Finland, Canada, and Slovenia, have discovered a novel and unexpected function of nestin, the best known marker of neural stem cells.

3 Jan 2019

New insights on cellular death mechanisms caused by the loss of neuronal cells and astrocytes

The blood circulation to neurons is affected due to Ischemic, hemorrhagic stroke and subarachnoid hemorrhage stimulation the activation of pathophysiological responses i.e. mitochondrial death pathways, protein misfolding, apoptosis, pyroptosis, necrosis, autophagy, mitophagy, ferritinophagy, excitotoxicity, free radicals release, and inflammation.

31 Dec 2018

Glial cell maturation is severely impaired in patients with Huntington's disease

The neurological disorder Huntington's disease causes behavioral and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain's support cells, researchers from the University of Copenhagen demonstrate in a new study based on mice trials.

24 Dec 2018

Researchers discover cost-efficient, accurate method to examine effectiveness of cardiomyocytes

A faster, more cost-efficient, and more accurate method of examining the effectiveness of human pluripotent stem-cell-derived cardiac muscle cells has been discovered, according to researchers from Penn State.

20 Dec 2018

Mouse study uncovers how marijuana may damage some adolescent brains

In a study of adolescent mice with a version of a gene linked to serious human mental illnesses, Johns Hopkins Medicine researchers say they have uncovered a possible explanation for how marijuana may damage the brains of some human teens.

18 Dec 2018

Study uncovers novel details about vulnerability of one brain cell to Alzheimer's

Better tactics for detecting, preventing and treating Alzheimer's disease depend on a clearer understanding of cellular-level changes in the minds of patients, and a new study has uncovered novel details about the vulnerability of one type of brain cell.

18 Dec 2018

Answering the Biggest Neurological Research Questions of Today

An interview with Dr. Peggy Taylor, discussing the biggest neurological research questions of today and how BioLegend is helping to develop new biomarkers for neurological disease.

From BioLegend 14 Dec 2018

New research lays out potential path for treatment of Huntington’s disease

New research gives scientists a clearer picture of what is happening in the brains of people with Huntington's disease and lays out a potential path for treatment.

14 Dec 2018

Researchers explore how glial cells develop in the brain from neural precursor cells

Two types of cells are active in the brain: nerve cells and glial cells. The latter have long been regarded primarily as supportive cells, but it is increasingly recognized that they play an active role in the communication between neurons in the brain.

10 Dec 2018

Novel approach gives new insights into formation of neurons in mammalian adult brain

A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Texas Children's Hospital has developed a powerful new approach to understand the formation of new neurons in the mammalian adult brain.

5 Dec 2018

Researchers uncover genes that lead to excessive tau in dementia

Researchers have identified two major groups of genes involved in the mutations that lead to excess production of tau, a protein involved in dementia.

3 Dec 2018

Researchers elucidate central mechanisms of salt-induced hypertension through sympathetic activation

Hypertension is a major risk factor for cardiovascular disease worldwide, and approximately 40% (1 billion) of adults aged 25 and above have been diagnosed with hypertension. A positive correlation between salt intake and blood pressure has long been postulated.

30 Nov 2018

Forming 3D Neuronal Models of the Brain

In this interview, conducted at SfN 2018, Grischa Chandy from Molecular Devices provides insight on 3D imaging solutions for neuroscience research.

From Molecular Devices, LLC 19 Nov 2018

Ten Allen Distinguished Investigators for 2018 announced by Paul G. Allen Frontiers Group

Nanoparticles that could reprogram a cancer patient's immune system inside their own body. Understanding a mysterious type of brain cell in the hopes of shedding new light on Alzheimer's disease. Reimagining nuclei, the DNA-storage compartments of our cells, as miniature lava lamps.

30 Oct 2018

Modeling Alzheimer’s Disease Using Microfluidics

An interview with Dr. Joseph Park, the incorporation of astrocytes into the Alzheimer’s-in-a-dish culture system and it's applications in drug development.

24 Oct 2018

How a single mutation can devastate cellular function

A scientist has shown how a single mutation in a protein found in astrocytes reproduces fibrous globs that devastate cellular function.

23 Oct 2018

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).

3 Oct 2018

Microglia lead to increased neuro-inflammation in fibromyalgia patients, finds study

A study by Massachusetts General Hospital researchers - collaborating with a team at the Karolinska Institutet in Sweden - has documented for the first time widespread inflammation in the brains of patients with the poorly understood condition called fibromyalgia.

28 Sep 2018

Toxicological evaluation and dosimetry estimation of potential PET radiotracer

The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesized by our group.

25 Sep 2018

Tiny sensors can measure dopamine levels in the brain for more than a year

Dopamine, a signaling molecule used throughout the brain, plays a major role in regulating our mood, as well as controlling movement. Many disorders, including Parkinson's disease, depression, and schizophrenia, are linked to dopamine deficiencies.

12 Sep 2018