Ataxia News and Research

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Ataxia is a neurological sign and symptom that consists of gross lack of coordination of muscle movements. Ataxia is a non-specific clinical manifestation implying disfunction of the parts of the nervous system that coordinate movement, such as the cerebellum.

Aripiprazole has potential for treating alcohol dependence

Aripiprazole is currently approved to treat bipolar disorder as well as schizophrenia. A new study has found that it significantly and dose-dependently increases the sedative effects of alcohol and, to a lesser degree, decreases the euphoric effects of alcohol. Future research will need to examine the beneficial versus the side effects of aripiprazole for treatment of alcohol dependence.

4 Apr 2008

Novel brain cancer drug HhAntag for children may damage bones

A novel drug that fully eliminated brain tumors from mice in a dramatic 2004 study has shown a darker side - causing permanent bone damage in younger mice.

11 Mar 2008

Omega-3 rich oils lower risk of memory problems, omega-6 rich oils may increase risk

A diet rich in fish, omega-3 oils, fruits and vegetables may lower your risk of dementia and Alzheimer's disease, whereas consuming omega-6 rich oils could increase chances of developing memory problems, according to a study published in the November 13, 2007, issue of Neurology, the medical journal of the American Academy of Neurology.

13 Nov 2007

Chicken pox vaccination should be introduced for children in the UK

The only realistic way of preventing deaths and severe complications arising from chickenpox is to routinely vaccinate children against the disease, concludes research published ahead of print in Archives of Disease in Childhood.

13 Nov 2007

Proteins involved in fragile X syndrome identified

The interplay of two proteins that bind to messenger RNA, a molecule that mediates translation of the information encoded in genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome (FTAX), a late-life disorder associated with the gene that causes fragile X syndrome in children, said researchers from Baylor College of Medicine in Houston and Emory University School of Medicine in a report that appears today in the journal Neuron.

17 Aug 2007

New insight into fragile X tremor/ataxia syndrome

Researchers have reported new insight into the pathology underlying a recently identified neurological disorder that strikes middle-aged adults that is caused by alterations in the same gene that causes fragile X syndrome.

17 Aug 2007

Scientists discover role of ataxia telangiectasia mutated protein in DNA repair

Scientists from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and Integrative Bioinformatics Inc. have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body's ability to repair damaged DNA.

28 Jun 2007

DNA repair proteins monitored at double-strand break

St. Jude investigators recently had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.

23 Jun 2007

Researchers explore the glycosylation process

By studying the addition of sugars to proteins — a process called glycosylation — in the nervous system of insects, Temple University researcher Karen Palter believes she may be able to better understand neurodegenerative diseases in humans.

28 May 2007

Researchers watch repair proteins arrive around DNA breaks

Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.

10 May 2007

Moonlighting enzyme linked to Friedreich's ataxia

Friedreich's ataxia is one of those diseases few have heard of unless you know someone with the condition.

25 Apr 2007

Gene produces springy protein keeping nerve cells flexible

If you bend a knee or an elbow, the nerves in your limbs stretch but do not break. A University of Utah study suggests why: A gene produces a springy protein that keeps nerve cells flexible. When the gene was disabled in tiny nematode worms, their nerve cells literally broke.

29 Jan 2007

Protection for nerve cells - eating up defective proteins

Nerve cells in the Central Nervous System can defend against and recover from damage by proteinlike clusters which are associated with neurodegenerative diseases such as Huntington's Chorea.

13 Sep 2006

Scientists unravel breast cancer risk gene mystery

The risk of developing breast cancer is doubled in women who inherit a damaged version of a gene called ATM, according to a study published by Cancer Research UK funded scientists and collaborators in Nature Genetics.

10 Jul 2006

New diagnostic approach for carriers of recessive genetic disorders

Scientists Vivian Cheung and Warren Ewens from the University of Pennsylvania have developed a new approach for the diagnosis of medical disorders that are inherited in a recessive manner.

3 Jul 2006

Scientists describe elaborate system of gene control triggered by chemical damage to DNA

Scientists describe for the first time a web of inter-related responses that cells use to avoid becoming diseased or cancerous after being exposed to a powerful mutagen.

7 Jun 2006

Penn researchers study link between potassium and sodium channels aiming at new treatments for neurological diseases

Researchers at the University of Pennsylvania School of Medicine have discovered the mechanism that facilitates how two ion channels collaborate in the control of electrical signals in the brain.

9 Mar 2006

Dual functions of sight - perception and action - demonstrated for first time

The dissociation in the visual system between two separate functions - one that enables us to identify objects and the other to interact with them - has been clearly demonstrated for the first time in healthy humans by researchers at the Hebrew University of Jerusalem.

7 Mar 2006

Researchers discover cause of episodic ataxia type-2

Researchers at the Albert Einstein College of Medicine of Yeshiva University have discovered the underlying cause of a type of ataxia, hereditary disorders characterized by poor balance, loss of posture and difficulty performing rapid coordinated movement.

7 Mar 2006

Cell-death mechanism linked to developmental and degenerative brain disorders

Conclusive evidence that neurodevelopmental disorders such as mental retardation and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and ataxias can be caused, at least in part, by specific gene defects that interfere with the electrical impulses of rapid-firing brain nerve cells called bursting neurons.

1 Mar 2006