Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

New finding could become glioblastoma’s Achilles heel

Glioblastoma is the most frequent and aggressive brain cancer due to its ability to escape the immune system. However, the way in which this tumor manages to induce this immune tolerance was not known in detail.

23 Sep 2019

Researchers discover how cancer cells can trigger chronic muscle wasting condition

A solid tumor can cause muscle cells in the body to self-destruct. Many cancer patients die from the consequences. Now researchers are discovering more about how cancer cells in a tumor can take control of muscle cell wasting and trigger a chronic, serious condition.

19 Sep 2019

New research suggests another possible mechanism for Alzheimer’s

Neurofibrillary plaques and tau protein are among the most widely known pathological entities characterizing Alzheimer’s disease (AD), but new research at the University of California, Riverside, has come up with another plausible explanation for this debilitating disorder.

13 Aug 2019

Researchers identify alternate chemistry that could account for Alzheimer's pathologies

Alzheimer's disease, the most common cause of dementia among the elderly, is characterized by plaques and tangles in the brain, with most efforts at finding a cure focused on these abnormal structures.

13 Aug 2019

Researchers identify genes linked to death from sepsis in mice

Sepsis is a life-threatening condition that occurs when the body's immune response to infection spirals out of control.

23 Jul 2019

Aging nerve cells fail to take out the intracellular "trash"

Researchers at the Perelman School of Medicine at the University of Pennsylvania, have found that with age the neurons or nerve cells fail to perform an activity that they could when they were younger. The team explains that normal cells take out protein and other “trash” or “garbage” through a process of autophagy. This rids the cell of the dysfunctional proteins and aggregates of unused proteins.

22 Jul 2019

Autophagy of dendritic cells supports T-cell anticancer activity

Autophagy contributes to the homeostasis of a cell and recently another function of autophagy has been reported. A KAIST research team found that the autophagy of dendritic cells supports T-cell anticancer activity.

13 May 2019

Researchers identify genetic component involved in development of familial sarcoidosis

Working with their colleagues from the University of Lyon, researchers from MedUni Vienna's Center for Pathobiochemistry and Genetics have discovered mutations in genes that regulate the metabolic sensor mTOR in patients with familial sarcoidosis.

8 May 2019

Drug that treats high blood pressure shows promise against neurodegenerative diseases

A prescribed drug to treat high blood pressure has shown promise against conditions such as Parkinson's, Huntington's and forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge.

19 Apr 2019

Study uncovers new biomarker for personalized cancer treatments

Cancer cells are characterized by the ability to evade apoptosis, a type of programmed cell death that allows the organism to remove damaged cells.

16 Apr 2019

Scientists investigate processes that lead to neuronal death in ALS patients

Amyotrophic lateral sclerosis is an incurable disease of the central nervous system. In most cases, ALS is fatal within a short period following diagnosis.

15 Apr 2019

Damaged mitochondria use 'eat me' signals for mitophagy

When mitochondria become damaged, they avoid causing further problems by signaling cellular proteins to degrade them.

12 Apr 2019

Autophagy can help combat Salmonella and other pathogens

Autophagy - the process of recycling cellular material in the body, can help combat Salmonella and other pathogens according to researchers at the School of Life Sciences, University of Warwick who have studied how autophagy can get rid of bacteria, and prevent diseases developing.

27 Mar 2019

VCU researchers home in on microRNA processing for new cancer therapies

More than a decade of research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs.

26 Mar 2019

A change in focus could enable the development of new treatments for Alzheimer's disease

New research by academics at Royal Holloway, University of London, urges scientists that are looking to finding a cure for Alzheimer's disease to focus on the role of proteins in the brain that cause Alzheimer's disease. T

22 Mar 2019

Researchers discover possible new therapeutic strategy for pancreatic cancer

Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers.

21 Mar 2019

New therapeutic approach for patients with pancreatic cancer

One-year survival is low among patients diagnosed with pancreatic cancer. Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients.

5 Mar 2019

New combinational drug therapy may effectively combat pancreatic cancer

Even among cancers, pancreatic cancer is an especially sinister form of disease. The one-year survival rate is extremely low, and treatment progress has lagged behind that of many other malignancies.

5 Mar 2019

New therapeutic approach offers promise for patients with pancreatic cancer

Lustgarten Foundation and Stand Up To Cancer, strategic partners in the Pancreatic Cancer Collective, offer comments on research published today in the journal Nature Medicine which describes a new therapeutic approach with promise for patients with pancreatic cancer.

5 Mar 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019