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Method to deliver molecules within embryonic stem cells improves differentiation

Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease.

10 Apr 2008

Methamphetamine addiction mechanism discovered

Researchers have identified, for the first time, long-term changes in the brain circuitry of methamphetamine-addicted mice that can explain why the craving of addiction is so stubborn and long-lived.

10 Apr 2008

Researchers identify gene involved in blood stem cell replication, movement

Researchers at the Joslin Diabetes Center have identified a gene that is responsible for the division and movement of marrow-derived, blood-forming stem cells, a finding that could have major implications for the future of bone marrow and blood cell transplantation.

10 Apr 2008

Research using human embryonic stem cells reveals earliest step in human development

Researchers at Johns Hopkins have uncovered the molecular underpinnings of one of the earliest steps in human development using human embryonic stem cells.

10 Apr 2008

How protein sludge accumulates in Alzheimer's

Researchers have identified a key mechanism by which the protein sludge that kills brain cells accumulates in Alzheimer's disease (AD).

10 Apr 2008

Soy appears to protect against development of breast cancer

Evidence is growing from animal and human studies that genistein, a potent chemical found in soy, protects against development of breast cancer - but only if consumed during puberty, says a Georgetown University Medical Center researcher in the British Journal of Cancer published online today.

10 Apr 2008

Better understanding of how T-cell leukemias and other disorders arise

Contrary to the currently accepted model of T-cell development, researchers at the University of Pennsylvania School of Medicine have found that juvenile cells on their way to becoming mature immune cells can develop into either T cells or other blood-cell types versus only being committed to the T-cell path.

10 Apr 2008

Scientists turn normal skin cells into cancer stem cells

With a bit of genetic trickery, researchers at the Stanford University School of Medicine have turned normal skin cells into cancer stem cells, a step that will make these naturally rare cells easier to study.

10 Apr 2008

Acute kidney injury with sepsis

ICU patients with septic acute kidney injury (AKI) are generally sicker, have a higher burden of illness, a greater risk of mortality and longer stays in hospital than patients with non-septic AKI.

10 Apr 2008

Tiny scaffolding inserted into brain could reduce damage caused by strokes

Inserting tiny scaffolding into the brain could dramatically reduce damage caused by strokes the UK National Stem Cell Network Annual Science Meeting will hear today (10 April).

10 Apr 2008

Too many gene copies stimulate tumor cell growth

New data, generated by Peter Lichter and colleagues, at the German Cancer Research Center, Heidelberg, have characterized a molecular pathway underlying low-grade forms of a type of brain tumor known as an astrocytoma.

9 Apr 2008

Solving the Z ring's mysteries may lead to new antibiotics

A team led by Johns Hopkins researchers has solved important puzzles concerning how certain proteins guide the reproduction of bacteria, discoveries that could lead to a new type of antibiotics.

9 Apr 2008

Special filter quickly and effectively removes deadly vCJD protein from blood

Amid concern that recipients of certain blood transfusions may risk infection with a deadly protein responsible for the human form of mad cow disease, researchers in Canada now report development of a special filter that quickly and effectively removes the protein from blood.

9 Apr 2008

High-dose chemo does not improve survival in small cell lung cancer

Small cell lung cancer (SCLC) patients treated with high-dose chemotherapy did not have better survival rates than those treated with standard doses, according to a randomized controlled trial published online April 8 in the Journal of the National Cancer Institute .

9 Apr 2008

Hepatitis B virus triggers cell 'suicide' in patients with chronic infection

Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so - that a group of cells important in controlling the disease are triggered to 'commit suicide' in patients who are chronically infected.

9 Apr 2008

Gene oppositely controlled by dietary protein, sugar

Researchers have discovered a gene in flies whose activity rises and falls depending upon the amount of protein and sugar in the insects' diets.

9 Apr 2008

Double binding sites on tumor target may provide future combination therapy

Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer.

9 Apr 2008

Discovery of a critical early player in the path that turns cells to fat

Given that obesity - defined as an excess amount of body fat relative to lean body mass - is a major health concern in the United States and an increasing problem in the developing world, such a fuller understanding of the molecular processes governing fat tissue formation could ultimately hold clinical importance, according to the researchers.

9 Apr 2008