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Which lung volumes to use for radiotherapy planning of lung cancer

A new method to standardize the reporting of radiation dose volumes in the use of four-dimensional computed tomography (4D-CT) can lead to a more accurate radiation dose to the lungs in lung cancers, thereby lowering the risk of lung injury, according to a study presented at the Plenary I session on October 29, 2007, at the American Society for Therapeutic Radiology and Oncology's 49th Annual Meeting in Los Angeles.

29 Oct 2007

Research clarifies origin of mammalian network of lymphatic vessels

Investigators at St. Jude Children's Research Hospital settled a century-old debate on the origin of the mammalian lymphatic vasculature - the network of vessels and capillaries critical to various essential housekeeping functions in the body.

29 Oct 2007

Researchers show evidence of 'memory' in cells and molecules

Research to be reported October 29 in the journal Proceedings of the National Academy of Sciences (PNAS) provides evidence that some molecular interactions on cell surfaces may have a "memory" that affects their future interactions.

29 Oct 2007

Odd protein interaction guides development of olfactory system

Scientists have discovered a strange mechanism for the development of the fruit fly antennal lobe, an intricate structure that converts the chaotic stew of odors in the environment into discrete signals in the brain.

29 Oct 2007

Discovery of new peptide communication factor in bacteria

Discovery by Hebrew University of Jerusalem researchers of a new communication factor that enables bacteria to "talk to each other" and causes their death could have significant consequences leading to development of a new class of antibiotic medications.

29 Oct 2007

Research finds novel mechanism for synovial inflammation in degenerative arthritis

The most common degenerative joint disease, osteoarthritis (OA) is marked by the breakdown of articular cartilage, which is the type of cartilage that lines the ends of most limb bones.

29 Oct 2007

Epilepsy-induced brain cell damage blocked in lab experiments

For some epilepsy patients, the side effects of epilepsy can be as troubling as the seizures.

29 Oct 2007

HIV vaccine trial volunteers asked to undergo testing to determine whether they are at increased risk of HIV

Researchers have asked more than 3,000 people who participated in a trial of Merck's experimental HIV vaccine that was halted last month to undergo additional testing to determine if they are at an increased risk of HIV, Reuters reports (Fox, Reuters, 10/25).

29 Oct 2007

Hairpin-shaped mimetics imitate the helical protein that plays a role in the spread of HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins.

29 Oct 2007

Twice the risk of cervical cancer despite operation

Women who have had severe cell changes in the cervix and who have been operated on for them run twice the risk of developing cancer later in life, compared with other women.

28 Oct 2007

Researchers find new mechanism explaining the promotional effect of H pylori on gastric cancer

The formation of a cancer is proven to be a multi-stage, multi-mechanism process by animal and human studies.

28 Oct 2007

Education program leads to lasting improvement of cancer knowledge in African Americans

Disparities in access to health care and education hinder minorities and socioeconomically disadvantaged populations from receiving needed cancer services and often lead to delayed cancer diagnoses.

28 Oct 2007

Discovery of a key cell-signaling pathway

University of Alabama at Birmingham (UAB) researchers have discovered a key cell-signaling pathway that regulates cell progression and switches on front-to-back body patterning in tadpoles.

28 Oct 2007

Scientists discover new causes for neurodegeneration

Diseases that cause neurons to break-down, such as Alzheimer's, Multiple Sclerosis and Creutzfeldt-Jakob disease (Mad Cow Disease), continue to be elusive to scientists and resistant to treatments.

25 Oct 2007

A new source of islet cells

The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells.

25 Oct 2007

Emerging cancer therapies and novel targets

What are the cancer drugs of tomorrow and how will they be developed? At the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers will present some answers to these and other pressing questions regarding emerging cancer therapeutics.

25 Oct 2007

Stanford researchers get precise picture of cell target for drugs

More than half of all drugs given to patients work by targeting a particular type of "docking station," or receptor, found on body cells, to steer the cell's machinery toward healing an illness.

25 Oct 2007

piRNAs play an important role in controlling gene function

A study by researchers at the Yale Stem Cell Center for the first time demonstrates that piRNAs, a recently discovered class of tiny RNAs, play an important role in controlling gene function, it was reported this week in Nature.

25 Oct 2007

Public not so sure about 'personalized medicine'

Ordinary people worry about the extra, and often burdensome, responsibilities which could come with scientists' promises of 'personalised medicine', according to evidence to be presented at a major two-day showcase of groundbreaking social science research into the whole field of genomics, funded by the Economic and Social Research Council (ESRC).

25 Oct 2007

Low-density lipoprotein may contribute to vascular diseases

Low-density lipoprotein (LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published online this week in EMBO reports.

25 Oct 2007