B Lymphocyte News and Research

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Scientists discover protein that boosts immunity to viruses and cancer

Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses...

17 Apr 2015

May issue of Red Journal focuses on role of radiation therapy in current lymphoma treatment

The "Radiation and the Modern Management of Lymphoma" issue (May 1, 2015) of the International Journal of Radiation Oncology • Biology • Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology, is focused on the integral role of radiation therapy in current lymphoma treatment.

17 Apr 2015

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

The 2015 Pezcoller Foundation-American Association for Cancer Research (AACR) International Award for Cancer Research will be presented to James P. Allison, PhD, at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

17 Apr 2015

Cardio3 BioSciences announces first patient enrollment in NKG2D CAR T-Cell Phase I clinical trial

Cardio3 BioSciences (C3BS), a leader in engineered cell-therapy treatments with clinical programs initially targeting indications in cardiovascular disease and oncology, today announced the enrollment of the first patient in a Phase I clinical trial evaluating the Company’s lead CAR T-Cell therapy, NKG2D CAR T-Cell, in blood cancer patients with acute myeloid leukemia (AML) or multiple myeloma (MM).

15 Apr 2015

New longer-term data on Genzyme's relapsing MS treatments to be presented at AAN 2015

Genzyme, a Sanofi company, announced today that new longer-term data on its relapsing multiple sclerosis treatments, Aubagio (teriflunomide) and Lemtrada (alemtuzumab), will be featured during the 67th annual meeting of the American Academy of Neurology being held in Washington, D.C. April 18-25.

15 Apr 2015

Portions of female reproductive tract likely to be infected by HIV, shows study

A Dartmouth study led by Charles Wira, PhD, with first author Marta Rodriguez-Garcia, MD, PhD, found that some portions of the female reproductive tract (FRT) are more likely to be infected by HIV, particularly the ectocervix compared to the endometrium.

10 Apr 2015

Andor Neo sCMOS camera is perfect partner for correlative microscopy

CD44 is recognised as an important cell surface receptor involved in the adhesion of circulating leukocytes to endothelium, a process that is critical for their trafficking in the vasculature. Now, a Japanese group of researchers using an ultra-sensitive Andor Neo sCMOS camera in their correlative microscopy set-up has demonstrated that microvilli projections around the cell surface mediate this adhesion.

From Andor Technology Ltd. 11 Mar 2015

Scientists develop promising new HIV vaccine agent

In a study that involved researchers from over a dozen institutions, the anti-HIV agent protected monkeys from every strain of HIV-1, HIV-2 and SIV (simian immunodeficiency virus) for at least 34 weeks.

19 Feb 2015

TSRI scientists develop new drug candidate against HIV

In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida campus of The Scripps Research Institute have announced the creation of a novel drug candidate that is so potent and universally effective, it might work as part of an unconventional vaccine.

18 Feb 2015

Findings show how human bodies restrict production of IgE to prevent allergic reaction

Scientists from the CNRS, INSERM and Université de Limoges, working in the Laboratoire Contrôle de la Réponse Immune B et Lymphoproliférations (CNRS/Université de Limoges) have demonstrated that the production of type E immunoglobulins (IgE) by B lymphocytes induces a loss in their mobility and the initiation of cell death mechanisms.

16 Feb 2015

Spaceflight may be associated with accelerated aging of the immune system

As the world waits to see if Mars One can establish a human colony on Mars, scientists are working to determine the long-term consequences of living in low or no-gravity conditions, such as those that might exist on the trip to another planet. New research published online in The FASEB Journal, shows that spaceflight may be associated with a process of accelerated aging of the immune system.

4 Feb 2015

Imperial College professor honored with Helmholtz International Fellow Award

The British cell biologist Professor Amanda Gay Fisher of Imperial College London has been honored with the Helmholtz International Fellow Award for her excellent research. Fisher is one of seven outstanding researchers from abroad who received the award, each of which is endowed with 20,000 euros. According to the Helmholtz Association, Germany's largest scientific organization, the award also includes an invitation to visit one or several Helmholtz research centers.

27 Jan 2015

Andor's Komet software used to automatically score modified 3D 'Comet' assay results

With cancer rates rising worldwide, and Cancer Research UK predicting that the lifetime risk of cancer will reach 50% by 2027, the need for early diagnosis is overwhelming. Now, a British research group has published details of a simple empirical test to detect any early-stage cancer, relying on Andor's Komet software to automatically score the modified 3D 'Comet' assay results.

From Andor Technology Ltd. 11 Dec 2014

$IMBRUVICA-rituximab combination well tolerated in patients with relapsed or refractory MCL$

IMBRUVICA-rituximab combination well tolerated in patients with relapsed or refractory MCL

New IMBRUVICA (ibrutinib) Phase II data announced by Pharmacyclics, Inc. today demonstrates its potential utility as a combination therapy when used with rituximab. Data suggest that the overall efficacy and safety profile of IMBRUVICA is well tolerated when combined with rituximab in patients with relapsed or refractory mantle cell lymphoma (MCL).

9 Dec 2014

MorphoSys, Xencor announce final results from MOR208 Phase 1/2a trial in patients with CLL/SLL

MorphoSys AG and Xencor Inc. today announced the publication of final results of a Phase 1/2a trial evaluating MOR208 (formerly XmAb5574) in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL).

7 Dec 2014

Study sheds new light on well-known mechanism required for immune response

A new study published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America sheds new light on a well-known mechanism required for the immune response. Researchers at the IRCM, led by Tarik Möröy, PhD, identified a protein that controls the activity of the p53 tumour suppressor protein known as the "guardian of the genome".

6 Dec 2014

EMA accepts new IMBRUVICA (ibrutinib) application for treatment of Waldenstrom's macroglobulinemia

Pharmacyclics, Inc.today announced the acceptance of a Type II variation application for IMBRUVICA (ibrutinib) by the European Medicines Agency.

1 Dec 2014

Protein complex plays key role in detecting tumor cells, promotes anti-tumor response

A recently discovered protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate studies published in the Nov. 20 issue of the journal Immunity.

21 Nov 2014

Induced neural stem cells hold promise for therapeutic transplantation

Induced neural stem cells (iNSCs) created from adult cells hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in the desirable multi-potent NSC state without continuous expression of the transcription factors used initially to reprogram them.

7 Nov 2014

Insufficient Th1 polarisation blocks RCC vaccine efficacy

A lack of a clinical response to an allogenic gene-modified renal cell cancer vaccine may be due to insufficient type 1 T-helper cell polarisation, show results of a gene expression profiling study.

30 Oct 2014

B Lymphocyte News and Research

Scientists discover protein that boosts immunity to viruses and cancer

May issue of Red Journal focuses on role of radiation therapy in current lymphoma treatment

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

Cardio3 BioSciences announces first patient enrollment in NKG2D CAR T-Cell Phase I clinical trial

New longer-term data on Genzyme's relapsing MS treatments to be presented at AAN 2015

Portions of female reproductive tract likely to be infected by HIV, shows study

Andor Neo sCMOS camera is perfect partner for correlative microscopy

Scientists develop promising new HIV vaccine agent

TSRI scientists develop new drug candidate against HIV

Findings show how human bodies restrict production of IgE to prevent allergic reaction

Spaceflight may be associated with accelerated aging of the immune system

Imperial College professor honored with Helmholtz International Fellow Award

Andor's Komet software used to automatically score modified 3D 'Comet' assay results

IMBRUVICA-rituximab combination well tolerated in patients with relapsed or refractory MCL

MorphoSys, Xencor announce final results from MOR208 Phase 1/2a trial in patients with CLL/SLL

Study sheds new light on well-known mechanism required for immune response

EMA accepts new IMBRUVICA (ibrutinib) application for treatment of Waldenstrom's macroglobulinemia

Protein complex plays key role in detecting tumor cells, promotes anti-tumor response

Induced neural stem cells hold promise for therapeutic transplantation

Insufficient Th1 polarisation blocks RCC vaccine efficacy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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